Acute Postinfectious Glomerulonephritis in Children

Rodríguez‐Iturbe, Bernardo; Najafian, Behzad; Silva, Alfonso; Alpers, Charles E.

doi:10.1007/978-3-642-27843-3_27-1

Cited by 3 publications

(11 citation statements)

References 140 publications

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“…The reduction in incidence of PSGN is attributed to a variety of factors, including easier and earlier medical treatment of streptococcal infections. PIGN frequency has been decreasing in worldwide but it is observed at a higher rate (9.3/100.000) in newly developing countries 1 . Dagan et al reported that 125 pediatric patients over the 17 years and they found the incidence of PIGN was highest (53.4%) during the winter months 8 .…”

Section: Discussionmentioning

confidence: 97%

“…Acute glomerulonephritis, one of the earliest clinical observations of nephrology, is known to last for more than 200 years with dark color and reduced urine after scarlet fever 1 . Post-infectious glomerulonephritis (PIGN) is the most common cause of acute glomerulonephritis in children 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Post-infectious glomerulonephritis (PIGN) is the most common cause of acute glomerulonephritis in children 2 . PIGN term defines as an acute glomerulonephritis which develops as a result of following various infections 1 . The typical clinical symptom of PIGN is acute nephritic syndrome accompanied by macroscopic or microscopic hematuria, edema, hypertension and mild-moderate proteinuria.…”

Section: Introductionmentioning

confidence: 99%

“…Post-infectious glomerulonephritis usually appears at the age of 4-15 years 1 . It is uncommon under 3 years of age.…”

Section: Introductionmentioning

confidence: 99%

“…PIGN occurs as a result of antigen-antibody reactivity. Nephritogenic immune complexes develop in the glomerular basement membrane (GBM) during circulation, causes local activation of complement system and coagulation cascade 1 .…”

Section: Introductionmentioning

confidence: 99%

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Post-enfeksiyöz glomerülonefrit sıklığı: tek merkez bulguları

Atmış¹,

Bayazıt²,

Melek³

et al. 2018

Cukurova Medical Journal

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The aim of this study was to retrospectively evaluate the incidence of post-infectious glomerulonephritis (PIGN) in department of Pediatric Nephrology at Cukurova University between November-December 2016. Materials and Methods: The clinical and laboratory datas of 13 children with PIGN who were seen in our clinic between November-December 2016, and their follow-up results were evaluated retrospectively. Results: Thirteen children who diagnosed PIGN were evaluated with the mean age of 9 (3-15) years. All of the patients had history of throat or gastrointestinal infections. Symptoms of the patients at admission were edema (100%), oliguria (38.5%), macroscopic hematuria (23%), hypertension (15.3%), dispnea (15.3%), respectively. Serum complement C3 was low in all patients while one patient had both low serum complement C3 and C4. The patient who had hypocomplementemia (both C3 and C4) also had severe proteinuria and acute kidney injury. Renal biopsy was performed to this patient and diagnosed diffuse proliferative glomerulonephritis after renal biopsy. Conclusion: PIGN is observed with higher incidence in the developing countries in current era. We detected an increase in the number of PIGN patients in a short period and we aimed to draw attention of pediatricians about PIGN patients with different clinical presentations. Amaç: Bu çalışmanın amacı Çukurova Üniversitesi Tıp Fakültesi Çocuk Nefroloji Bilim Dalında Kasım-Aralık 2016 aylarında başvuran hastalarda post-enfeksiyöz glomerülonefrit (PIGN) tanı sıklığını geriye dönük değerlendirmektir.. Gereç ve Yöntem: Bu tarihlerde kliniğimize başvuran 13 PIGN'li çocuk hastanın klinik, laboratuvar sonuçları ve takiplerinin sonuçları incelenmiştir. Bulgular: Çalışamaya alınan 13 PIGN tanılı çocuğun ortalama yaşı 9 (3-15) idi. Tüm hastaların üst solunum yolu veya gastrointestinal enfeksiyon öyküsü vardı. Başvuru şikayetleri sıklık sırasına göre ödem (%70), oligüri (%38,5), makroskobik hematüri (%23), hipertansiyon (%15,3), nefes darlığı (%15,3) idi. Kompleman C3 tüm hastalarda düşük iken bir hastada C3 ve C4 düşüklüğü vardı. Aynı hastada nefrotik düzeyde proteinüri ile birlikte akut böbrek yetmezliği vardı. Bu hastaya böbrek biyopsisi yapılarak diffüz proliferatif glomerülonefrit tanısı konuldu. Sonuç: Günümüzde PIGN gelişmekte olan ülkelerde daha yüksek oranda görülmektedir. Biz de kısa bir dönem içerisinde PIGN hasta sayısında artış tespit ettik ve bu çalışma ile farklı klinik başlangıcı ve seyri olan bu hastalar için genel pediatri hekimlerinin dikkatini çekmeyi amaçladık.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Post-infectious glomerulonephritis usually appears at the age of 4-15 years 1 . It is uncommon under 3 years of age.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Post-enfeksiyöz glomerülonefrit sıklığı: tek merkez bulguları

Atmış¹,

Bayazıt²,

Melek³

et al. 2018

Cukurova Medical Journal

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Glomerulonefritis post infecciosa en Pediatria

Ladoux

2020

Pediatr (Asunción).

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Management and outcomes of acute post-streptococcal glomerulonephritis in children

Ong¹

2022

World J Nephrol

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Acute post-streptococcal glomerulonephritis (APSGN) is the major cause of acute glomerulonephritis among children, especially in low- and middle-income countries. APSGN commonly occurs following pharyngitis due to the activation of antibodies and complements proteins against streptococcal antigens through the immune-complex-mediated mechanism. APSGN can be presented as acute nephritic syndrome, nephrotic syndrome, and rapidly progressive glomerulonephritis, or it may be subclinical. The management of APSGN is mainly supportive in nature with fluid restriction, anti-hypertensives, diuretics, and renal replacement therapy with dialysis, when necessary, as the disease is self-limiting. Congestive heart failure, pulmonary edema, and severe hypertension-induced encephalopathy might occur during the acute phase of APSGN due to hypervolemia. APSGN generally has a favorable prognosis with only a small percentage of patients with persistent urinary abnormalities, persistent hypertension, and chronic kidney disease after the acute episode of APSGN. Decreased complement levels, increased C-reactive protein, and hypoalbuminemia are associated with disease severity. Crescent formations on renal biopsy and renal insufficiency on presentation may be the predictors of disease severity and poor outcomes in APSGN in children.

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Acute Postinfectious Glomerulonephritis in Children

Cited by 3 publications

References 140 publications

Post-enfeksiyöz glomerülonefrit sıklığı: tek merkez bulguları

Post-enfeksiyöz glomerülonefrit sıklığı: tek merkez bulguları

Glomerulonefritis post infecciosa en Pediatria

Management and outcomes of acute post-streptococcal glomerulonephritis in children

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