“…The etiology of delusion in the postoperative period is multifactorial. 2 Contributing factors include certain drugs, including ketamine, neuroleptics, hallucinogens, and anticholinergics; withdrawal syndromes such as from alcohol, barbiturates, cocaine, opiates, and benzodiazepines; underlying central nervous system disorders, such as dementia, parkinsonism, and alcoholic brain syndrome; cerebrovascular insufficiency, such as from peripheral vascular disease, hypoxia, carbon monoxide poisoning, severe anemia, hypotension, and decreased cardiac output states; metabolic and endocrine factors, such as uremia, hepatic encephalopathy, adrenal insufficiency, hypoglycemia, hyponatremia, and hypercalcemia; preexisting psychiatric illnesses, such as underlying psychosis or neurosis, endogenous depression, phobic states, and personality disorders; postoperative pain; bladder and bowel distention; and extremes of age. 2 We present a case of emergence delirium following an uneventful endoscopic sinus surgery and discuss a potential mechanism.…”