Acute progression of interstitial lung disease: a complication of etanercept particularly in the presence of rheumatoid lung and methotrexate treatment

Diffuse Alveolar Hemorrhage and Acute Respiratory Distress Syndrome During Treatment of Rheumatoid Arthritis With Etanercept

“…Acute progression of interstitial lung disease as a complication of etanercept in the presence of rheumatoid lung and methotrexate treatment has also been described. 8 Combination of etanercept and corticosteroids has been successfully used to treat idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation. 9 A recent letter submitted to Lancet reported 4 patients receiving etanercept who acquired drug-induced systemic lupus erythematous.…”

The lung in rheumatoid arthritis

“…The impact of newer therapies for RA (e.g., anti-TNF-alpha regimens), which decrease inflammation and may interfere with fibrosis, is still unknown [53]. However, the potential benefit of anti-TNFalpha therapy should be viewed in the context of several cases of rapid, occasionally fatal progression of lung disease in patients with RA-associated ILD treated with anti-TNF therapy [54,55]. About a third of patients with RA have their joint disease controlled by methotrexate.…”

Rheumatoid arthritis-associated interstitial lung disease

“…Bu ilaçlar d›fl›nda metotreksat, siklosporin ve anti-TNF alfa'n›n RA ile iliflkili ‹AH tedavisindeki etkinli¤i ile ilgili olarak s›n›rl› ancak çeliflkili sonuçlar bildirilmifltir. [55][56][57][58][59] Prospektif gözlemsel bir çal›fl-mada anti-TNF alfa tedavisi alan 367 RA iliflkili ‹AH hastas›nda bu tedavi sonras› mortalitede bir art›fl olmad›-¤› bildirilmifltir. [60] Abatasept, insan CTLA4'ün eksternal zincir (domain) bölümü ile insan IgG1'in a¤›r zincirinin sabit bölümünden meydana gelen ve son y›llarda RA tedavisinde kullan›lan ilaçlardan biridir.…”