Acute promyelocytic leukemia and HIV‐1 infection: Case report and review of the literature

Kudva, Ganesh C.; Maliekel, Kochurani; Richart, John M.; Batanian, Jacqueline R.; Grosso, Leonard E.; Sokol-Anderson, Marcia L.; Petruska, Paul J.

doi:10.1002/ajh.20192

Cited by 12 publications

(12 citation statements)

References 12 publications

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“…In those reported cases, patient treated with the combined therapy of ATRA and chemotherapy entered a remission [1-5]. However, only two patients who concomitantly received antiretroviral therapy achieved sustained remission [2,3]. Our patient achieved stable complete remission with induction therapy of ATRA and antracycline followed by reduced intensity consolidation therapy with ATRA, and concomitant HAART.…”

Section: To the Editormentioning

confidence: 64%

Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphomainan HIV-infected patient

et al. 2009

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The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here, we report a case of an HIV-patient who developed APL and upon treatment entered a complete remission. A 25-years old male patient was diagnosed with HIV-infection in 1996, but remained untreated. In 2004, the patient was diagnosed with primary central nervous system lymphoma. We treated the patient with antiretroviral therapy and whole-brain irradiation, resulting in complete remission of the lymphoma. In 2006, prompted by a sudden neutropenia, we carried out a set of diagnostic procedures, revealing APL. Induction therapy consisted of standard treatment with all-trans-retinoic-acid (ATRA) and idarubicin. Subsequent cytological and molecular analysis of bone marrow demonstrated complete hematological and molecular remission. Due to the poor general condition, consolidation treatment with ATRA was given in March and April 2007. The last follow-up 14 months later, showed sustained molecular APL remission. In conclusion, we demonstrated that a complete molecular APL remission in an HIV-patient was achieved by using reduced-intensity treatment.

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Section: To the Editormentioning

confidence: 64%

Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphomainan HIV-infected patient

et al. 2009

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“…The current study presents the third case of APL with ct(15;17;v) involving chromosome 16. The first was described in a human immunodeficiency virus patient with secondary APL and the second was described in an APL patient with four chromosome translocations involving chromosomes 5, 15, 16 and 17 (23,29). However, the breakpoint of chromosome 16 in the current case (16q24) was different from those identified in the two previously reported cases.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of t(15;17) and t(15;16;17) detected by fluorescence in situ hybridization in a patient with acute promyelocytic leukemia: A case report and literature review

et al. 2014

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Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current study presents the case of a 54-year-old female with APL carrying the atypical PML/RARA fusion signal due to a novel complex variant translocation t(15;16;17)(q22;q24;q21), as well as the classical PML/RARA fusion signal. Subsequent array comparative genomic hybridization revealed somatic, cryptic deletions on 3p25.3, 8q23.1 and 12p13.2-p13.1, and a duplication on 8q11.2; however, no genetic material loss or gain was observed in the breakpoint regions of chromosomes 15, 16 or 17. To the best of our knowledge, this is the first report of the coexistence of two abnormal clones, one classical and one variant, presenting simultaneously in addition to cryptic chromosome segmental imbalances in an adult APL patient.

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“…The use of HAART was not reported in three of these cases. All three patients with APL and HIV infection treated with ATRA achieved a complete remission (Calvo et al, 1997, Kudva et al, 2004. Furthermore, the CD4 + cell count decreased during therapy, but increased once the treatment was completed, and the patient did not suffer any HIVassociated complications (Kudva et al, 2004).…”

Section: Effects Of Hiv Infectionmentioning

confidence: 91%

“…Interestingly, ATRA could reduce viral replication not only in the 8E5 cell line but in the primary lymphocytes from HIV patients. Regarding ATRA and HIV infection, there are several interesting reports (Calvo et al, 1997, Kudva et al, 2004. Briefly, four patients were diagnosed with HIV infection and APL at the same time.…”

Section: Effects Of Hiv Infectionmentioning

confidence: 99%

Retrovirus Infection and Retinoid

Maeda¹,

Kawauchi²,

Hirase³

et al. 2011

T-Cell Leukemia

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Acute promyelocytic leukemia and HIV‐1 infection: Case report and review of the literature

Cited by 12 publications

References 12 publications

Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphomainan HIV-infected patient

Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphomainan HIV-infected patient

Coexistence of t(15;17) and t(15;16;17) detected by fluorescence in situ hybridization in a patient with acute promyelocytic leukemia: A case report and literature review

Retrovirus Infection and Retinoid

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