Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review

Mendes-de-Almeida, Daniela P.; Fernandez, Teresa de Souza; Lovatel, Viviane Lamim; Rocha, Moises Martins da; Gomes, Bernadete Evangelho; Monte-Mór, Bárbara; Vianna, Danielle T.; Alcoforado, Marília T.G.; Kronemberg, João Marcello P.B.; Cardoso, João Pedro S.C.; Oliveira, Vanessa G.; Bokel, Joanna; Vizzoni, AG; Nunes, Estêvão Portela; Grinsztejn, Beatriz

doi:10.1016/j.lrr.2022.100339

Cited by 1 publication

(4 citation statements)

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“…As the incidence of APL in patients infected with HIV is sporadic, the therapeutic approach is individualized and often challenging (2,4,8). Recently, with the advent of novel therapies, survival of patients with HIV and APL has improved but there are no relevant guidelines for treatment of the concomitant HIV and APL (6,7,(9)(10)(11)(12)(13)(14). Therefore, evaluating the mechanism and clinical characteristics of these cases is important.…”

Section: Discussionmentioning

confidence: 99%

“…APL is among the highly curable hematological neoplastic diseases with a 10-year OS rate of 93.9% owing to the use of ATRA and ATO (42). A total of 13 cases of APL with HIV have been reported (Tables II and III) (2,4,(6)(7)(8)(9)(10)(11)(12)(13)(14). Of these, treatment and survival details are unavailable for one case (9).…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of HIV with APL is extremely rare, with only 12 cases reported to date, and it is even rarer in the chromosomally complex APL population. Due to the small number of cases, there is no uniform standard of treatment for APL complicated with HIV, and the prognosis remains unclear (2,4,(6)(7)(8)(9)(10)(11)(12)(13)(14). The status of patients infected with HIV and initiation and course of chemotherapy are increasingly a cause of concern due to the highly effective HAART and its success in controlling viral load (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Due to the small number of cases, there is no uniform standard of treatment for APL complicated with HIV, and the prognosis remains unclear (2,4,(6)(7)(8)(9)(10)(11)(12)(13)(14). The status of patients infected with HIV and initiation and course of chemotherapy are increasingly a cause of concern due to the highly effective HAART and its success in controlling viral load (6,7). The present report describes a case of high-risk APL with additional chromosomal abnormalities and HIV infection and discusses the existing literature on this unique population.…”

Section: Introductionmentioning

confidence: 99%

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Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review

Li,

Wang

et al. 2024

Oncol Lett

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Acute promyelocytic leukemia (APL), especially cases of high-risk with complex chromosomes (CK), is rare in individuals infected with human immunodeficiency virus (HIV), making the establishment of therapeutic approaches challenging; often the treatment is individualized. This report describes a 49-year-old female patient with HIV who was diagnosed with high-risk APL with a new CK translocation and presents a literature review. At diagnosis, the patient presented with typical t(15;17)(q24;q21) with additional abnormalities, including add(5)(q15), add(5)(q31), add(7)(q11.2) and add(12) (p13). The results of acute myeloid leukemia mutation analysis suggested positivity for calreticulin and lysine methyltransferase 2C genes. The patient received all-trans retinoic acid combined with arsenic trioxide and chemotherapy, with morphologically complete remission after the first cycle of chemotherapy. The present report provided preliminary data for future clinical research.

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