2009
DOI: 10.1016/j.cancergencyto.2008.09.002
|View full text |Cite
|
Sign up to set email alerts
|

Acute promyelocytic leukemia with insertion of PML exon 7a and partial deletion of exon 3 of RARA: a novel variant transcript related to aggressive course and not detected with real-time polymerase chain reaction analysis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
19
0

Year Published

2010
2010
2018
2018

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 28 publications
(20 citation statements)
references
References 7 publications
1
19
0
Order By: Relevance
“…[14][15][16][17][18][19][20] Both the microgranular subtype of APL and the much less common hyperbasophilic subtype are often termed APL variants. 14 This term is also applied to variant (three-way) translocations involving PML-RARA.…”
Section: So-called Apl Variant (Aml With Variant Rara Translocations)mentioning
confidence: 99%
“…[14][15][16][17][18][19][20] Both the microgranular subtype of APL and the much less common hyperbasophilic subtype are often termed APL variants. 14 This term is also applied to variant (three-way) translocations involving PML-RARA.…”
Section: So-called Apl Variant (Aml With Variant Rara Translocations)mentioning
confidence: 99%
“…Three regions of the PML locus are primarily involved in the t(15;17) translocation breakpoint cluster regions (bcrs): intron 6 (bcr1), exon 6 (bcr2) and intron 3 (bcr3), whereas RARA breakpoints always occur in intron 2. As a consequence, there are three possible PML-RARA isoforms, referred to the as long (bcr1), variant (bcr2) and short (bcr3) isoforms (9). …”
Section: Introductionmentioning
confidence: 99%
“…In rare cytogenetically normal cases, FISH or molecular methods demonstrate the presence of the PML-RARA fusion gene without the reciprocal RARA-PML, resulting from a submicroscopic insertion of RARA into PML. Since this cryptic insertion has rarely been reported, no prognostic significance has been clearly established (9,1122); however, a prompt diagnosis and the administration of targeted therapies, including all- trans retinoic acid (ATRA) and arsenic trioxide (ATO), are essential to improve the outcome in these patients (21). Due to the use of contemporary targeted therapy, APL has become a highly curable disease with complete remission rates of >95% and cure rates of >80% (2327).…”
Section: Introductionmentioning
confidence: 99%
“…In our previous study, a patient having a transcript with insertion of PML exon 7a and partial deletion of RARA exon 3 showed an aggressive course [10]. On the contrary, patients having PML exon 4 and RARA exon 3 fusion transcript never show a poor prognosis (table 1).…”
Section: Figmentioning
confidence: 99%