Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment

Todorović, Zoran; Nesic, Zorica; Stojanović, Rastko; Basta-Jovanović, Gordana; Radojević-Škodrić, Sanja; Velickovic, Ruzca; Chatterjee, Prabal K.; Thiemermann, Christoph; Prostran, Milica

doi:10.1254/jphs.sc0070374

Cited by 29 publications

(21 citation statements)

References 15 publications

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“…Pre-conditioning for 5 days with cerivastatin resulted in renal protection in mice subjected to iAKI (10) . In addition, the administration of simvastatin in a model of renal I/R resulted in a reduction in the area of acute tubular necrosis, which was confirmed by histological data and improvement in tubular function (11) . Studies have confirmed the power of statins as renoprotective agents due to their anti-inflammatory and antioxidant actions, two mechanisms that are significant in iAKI.…”

Section: Discussionsupporting

confidence: 52%

Sinvastatina e lesão renal aguda isquêmica em ratos

Teshima¹,

Watanabe²,

Fonseca³

et al. 2012

Acta paul. enferm.

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Objectives:The study aimed to verify the protective renal action of simvastatin in an animal model of ischemia / reperfusion for 30 minutes. Methods: Ischemia was obtained by clamping bilateral renal pedicles for 30 minutes, followed by reperfusion. Male Wistar rats were used, weighing between 250-300g, distributed into the following groups: SHAM (control, without clamping renal), Ischemia (renal ischemia for 30 minutes), Ischemia + Statin (simvastatin 0.5 mg/kg, orally for three days). Renal function (creatinine clearance, Jaffé method), urinary osmolality, and urinary peroxides were evaluated. Results: The results showed that the statin improved renal function, and reduced urinary osmolality along with excretion of PU. Conclusion: In summary, the study confirmed the protective renal effects of statins, with an antioxidant action that protects the kidney. Keywords: Acute kidney injury; Ischemia; Simvastatin/adverse effects; Rats RESUMOObjetivos: O estudo visou verificar a ação renoprotetora da sinvastatina em modelo animal de isquemia/reperfusão por 30 minutos. Métodos: A isquemia foi obtida por meio do clampeamento dos pedículos renais bilaterais por 30 minutos, seguida de reperfusão. Ratos Wistar, machos foram usados pesando entre 250-300g, distribuídos nos seguintes grupos: SHAM (controle, sem clampeamento renal); Isquemia (isquemia renal por 30 minutos); Isquemia+Estatina (sinvastatina 0,5 mg/kg, via oral durante três dias). A função renal (clearance de creatinina, método de Jaffé), a osmolalidade urinária, os peróxidos urinários foram avaliados. Resultados: Os resultados mostraram que a estatina melhorou a função renal, a osmolalidade urinária e reduziu a excreção de PU. Conclusão: Em síntese, o estudo confirmou o efeito renoprotetor da estatina, com ação antioxidante de proteção renal. Descritores: Lesão renal aguda; Isquemia; Sinvastatina/efeitos adversos; Ratos RESUMENObjetivos: El estudio tuvo como objetivo verificar la acción renoprotectora de la simvastatina en modelo animal de isquemia/reperfusión por 30 minutos. Métodos: La isquemia se obtuvo por medio del pinzamiento de los pedículos renales bilaterales por 30 minutos, seguida de la reperfusión. Fueron usadas ratas Wistar, machos que pesaban entre 250-300g, distribuidos en los siguientes grupos: SHAM (control, sin pinzamiento renal); Isquemia (isquemia renal por 30 minutos); Isquemia+Estatina (simvastatina 0,5 mg/kg, via oral durante tres días). Fueron evaluadas la función renal (clearance de creatinina, método de Jaffé), la osmolaridad urinaria y los peróxidos urinarios. Resultados: Los resultados mostraron que la estatina mejoró la función renal, la osmolaridad urinaria y redujo la excreción de PU. Conclusión: En síntesis, el estudio confirmó el efecto renoprotector de la estatina, con acción antioxidante de protección renal. Descriptores: Lesión renal aguda; Isquemia; Simvastatina/efectos adversos; Ratas

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Section: Discussionsupporting

confidence: 52%

Sinvastatina e lesão renal aguda isquêmica em ratos

Teshima¹,

Watanabe²,

Fonseca³

et al. 2012

Acta paul. enferm.

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“…Sixty minutes of ischemia does not increase MDA levels, whereas 15 min of reperfusion results in a large increase in kidney lipid peroxidation and aggravates cell injury. 20,21 Hence, Bai administration 30 min before reperfusion can protect the kidney.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of baicalein on renal ischemia/reperfusion injury in the rat

Tian

et al. 2014

Renal Failure

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Objective: To investigate the protective effect and the mechanism of baicalein (Bai) in rats with renal ischemia-reperfusion injury (RIRI). Methods: Twenty-four male Sprague-Dawley rats were divided into three groups: sham, IR, and IR + Bai. Bai was administered by tail vein injection (30 mg/kg) 30 min before reperfusion in the IR + Bai group. The IR group and sham group received saline vehicle via the intravenous route. Results: Rats that underwent RIRI exhibited renal functional impairment, histological changes, significantly increased advanced oxidation protein product (AOPP) and malondialdehyde (MDA) levels (p50.01), and ICAM-1 and MCP-1 protein and mRNA expression were significantly upregulated (p50.01). Administration of Bai reduced AOPP and MDA levels, significantly inhibited expression of inflammatory factors (p50.05), and markedly improved renal function. Conclusion: Bai promotes the recovery of renal function in established acute RIRI, and alleviates kidney injury in a rat model.

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“…32 Due to their antiinflammatory effects and protective role in preventing ischemia-reperfusion injury, it has been hypothesized that statins may provide beneficial effects in renal transplant recipients. 57 The one major randomized trial conducted on the effects of statins on renal transplant recipients was the ALERT (Assessment of Lescol in Renal Transplant) trial. 58 A total of 2,102 posttransplant patients were randomized to either 40 mg daily of fluvastatin or placebo, with a mean follow-up of 5 years.…”

Section: Statins and Renal Transplantmentioning

confidence: 99%

The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in renal disease

Gomez¹,

Mihos²,

Pineda³

et al. 2014

IJNRD

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Abstract:It is well known that statins exert their main effect by inhibiting cholesterol synthesis through the inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase enzyme. The pleiotropic effects of statins, which are independent of their inhibition of cholesterol synthesis, have explained many of the beneficial effects of these drugs in a variety of disorders such as malignancies, infection, and sepsis, as well as in cardiovascular and rheumatologic disorders. However, the role of these drugs in renal disorders remains controversial. In the present review, we examine the most recent findings involving statins and renal disease among different clinical scenarios, including chronic kidney disease, contrast-induced nephropathy, renal injury after coronary artery bypass surgery, and renal transplant patients.

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Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment

Cited by 29 publications

References 15 publications

Sinvastatina e lesão renal aguda isquêmica em ratos

Sinvastatina e lesão renal aguda isquêmica em ratos

Protective effect of baicalein on renal ischemia/reperfusion injury in the rat

The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in renal disease

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