Acute psychological stress alerts the adaptive immune response: Stress-induced mobilization of effector T cells

Atanackovic, Djordje; Schnee, Benjamin; Schuch, Gunter; Faltz, Christiane; Schulze, Julia; Weber, Cora; Schafhausen, Philippe; Bartels, Katrin; Bokemeyer, Carsten; Brunner‐Weinzierl, Monika C.; Deter, Hans‐Christian

doi:10.1016/j.jneuroim.2006.03.023

Cited by 51 publications

(42 citation statements)

References 56 publications

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“…The epinephrine-induced mobilization of effector CD8 + T cells is consistent with previous studies of increased effector CCR7 2 / CD62L 2 CD45RA + CD8 + T cell numbers after stress or catecholamine administration (19,22,25). These effector CD8 + T cells represent a stage of T cell differentiation occurring late in the immune response, and are hence called terminally differentiated cytotoxic T cells.…”

Section: Discussionsupporting

confidence: 90%

“…Effector CD8 + T cells can also express the NK cell marker CD56 that seems to define those cells with high direct cytolytic capacity (42,45). Hence, the epinephrine-induced increase in CD3 + CD56 + NKT-like cells observed in the current as well as in previous studies (22,42) might to some extent overlap with a mobilization of effector CD8 + T cells. Our findings of substantial mobilization of g/d T cells after epinephrine likewise agrees with the view of a first line of (47).…”

Section: Discussionsupporting

confidence: 61%

“…Stress as well as diurnal increases in SNS activity mobilize cells with low expression of Lselectin (CD62L) and high expression of integrin LFA-1 (CD11a) such as effector memory (EM) and effector CD8 + T cells, CD16 to changes in catecholaminergic activity (10,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Along with the CD62L 2 CD11a bright phenotype, effector immune cells are generally characterized by high expression of inflammatory chemokine receptors, such as CCR5, CXCR1, CXCR3, and CX3CR1 (26)(27)(28).…”

mentioning

confidence: 99%

“…Along with the CD62L 2 CD11a bright phenotype, effector immune cells are generally characterized by high expression of inflammatory chemokine receptors, such as CCR5, CXCR1, CXCR3, and CX3CR1 (26)(27)(28). Despite all these findings and that chemokines are main regulators of leukocyte traffic, the role of chemokine receptors in SNS-induced demargination of leukocytes has attracted surprisingly little attention (22,24,(29)(30)(31).…”

mentioning

confidence: 99%

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Selective Mobilization of Cytotoxic Leukocytes by Epinephrine

Dimitrov

Lange

Born³

2009

The Journal of Immunology

198

150

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It is well-known that acute stress, presumably as a first defense against pathogens, enhances PBMC counts by mobilizing these β2-adrenoceptor positive cells from the marginal pool. Yet, only select leukocyte subsets participate in this phenomenon of adrenergic leukocytosis and underlying mechanisms are obscure. In this study, we analyzed in human blood adhesion molecule and chemokine receptor profiles in 14 leukocyte subsets, and responsiveness of subsets to epinephrine in vivo and in vitro. Five subsets, namely, CCR7−CD45RA+CD8+ effector T cells, CD4−CD8− γ/δ T cells, CD3+CD56+ NKT-like cells, CD16+CD56dim cytotoxic NK cells, and CD14dimCD16+ proinflammatory monocytes showed a rapid and transient increase after infusion of epinephrine at physiological concentrations. These cells were characterized by a CD62L−CD11abrightCX3CRbright phenotype, whereby expression of both CD11a and CX3CR1 was strongly correlated with adrenergic leukocytosis in vivo (r = 0.86 and 0.78, p < 0.005). The same subsets showed highest adherence to activated endothelium in vitro, which (except for proinflammatory monocytes) was reversed by epinephrine. We conclude that these five cytotoxic effector leukocyte subsets comprise the marginal pool by a CD11a/CX3CR1-mediated attachment to the endothelium. Epinephrine rapidly attenuates this attachment to allow demargination and release of the cells into the circulation that, because of their cytotoxic effector function, provide immediate protection from invading pathogens.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 61%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Selective Mobilization of Cytotoxic Leukocytes by Epinephrine

Dimitrov

Lange

Born³

2009

The Journal of Immunology

198

150

View full text Add to dashboard Cite

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“…Одновре-менно авторами наблюдалось нарушение про-лиферативной активности лимфоцитов (задолго до экзаменов), при этом подчеркивается, что сразу после воздействия стрессора число цито-токсических Т-клеток и натуральных киллеров возрастает благодаря мобилизации пула из депо, а их пролиферативная активность в ответ на ми-тоген падает. Фагоцитарная активность макро-фагов возрастала, однако острый стресс снижал чувствительность данных клеток к повторному воздействию стрессовых гормонов [5,8,11,12]. Перечисленные реакции системы иммунитета коррелировали с выраженностью реакций кар-диоваскулярной системы: повышение частоты сердечных сокращений, уровней систолическо-го и диастолического артериального давления, уменьшение величины кардиоинтервала [7,9].…”

Section: результаты и обсуждениеunclassified

Features of Immune Reactions in Stress Conditions Associated Associated With Exams

Широлапов¹,

Пятин²,

Лавров³

2014

Med. immunol.

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ОсОбеннОсти иммунОлОгических пОказателей в услОвиях экзаменациОннОгО стрессаШиролапов И.В., Пятин В.Ф., Лавров О.В. ГОУ ВПО «Самарский государственный медицинский университет» Минздравсоцразвития России, г. СамараРезюме. В условиях воздействия психоэмоциональных стрессоров обеспечивается постоянное тесное взаимодействие нервной, эндокринной и иммунной физиологических регуляторных систем. У 203 студентов вуза изучены особенности клеточных и гуморальных показателей системы имму-нитета при экзаменационном стрессе. Установлено снижение абсолютного и относительного со-держания CD3 + Т-лимфоцитов, субпопуляции клеток с функцией естественной цитотоксичности (CD3 -CD16 + CD56 + и CD3 + CD16 + CD56 + клеток) после экзамена по сравнению с таковым до экзаме-на. Выявлено снижение значений CD3 -CD19 + , CD3 + CD4 + и CD3 + CD8 + лимфоцитов после экзамена относительно контрольного периода измерений. Сывороточные концентрации иммуноглобулинов A, M, G находились в пределах физиологических значений нормы. Изменения иммунологических показателей при остром экзаменационном стрессе зависят от особенностей вегетативных и гормо-нальных реакций человека и в определенных условиях -предельных по интенсивности и длительно-сти -психоэмоциональный стресс может вызвать общие нарушения иммунного реагирования. It has been widely accepted that routine psychophysiological stressors may influence immune functioning via their close interactions between nervous, autonomic, endocrine and immune regulatory systems. The aim of this study was to evaluate immune reactions to acute psychophysiological stress in 203 medical students before and after academic exams. The results showed significant decrease of absolute and relative contents CD3 + T cells, natural killer (NK) cell subpopulations and T-NK cells (CD3 -CD16 + CD56 + and CD3 + CD16 + CD56 + ), as well as declined NK cell activity were revealed immediately after exams, as compared to initial values for these indices. Moreover, a significant decrease in CD19 + B cells, CD4 + T-helpers and CD8 + T-cytotoxic lymphocyte counts was found after exams, in comparison with parameters assessed under stress-free conditions, but no differences were observed, when compared with pre-examination values. Serum concentrations of IgA, IgM, IgG were within normal physiological limits. Changes in immunological parameters during acute examination-associated stress depend on characteristics of autonomous and hormonal reactions in humans, and, under particular extreme conditions, such psycho-emotional stress may cause general disturbances of immune reactions. We conclude that acute psycho-physiological stress during the exams causes significant changes in some lymphocyte subpopulations, in particular, natural killers.

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The Effects of Chewing Gum on Perceived Stress and Wellbeing in Students Under a High and Low Workload

Smith

Clayton

2020

Communications in Computer and Information Science

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Research has suggested that chewing gum relieves perceptions of stress in stressed and nonstressed individuals, but is most beneficial for those experiencing a greater amount of negative work characteristics. To determine if this was true in a student sample, the present study assigned 36 students to four one-day intervention conditions in which participants either chewed or refrained from gum and experienced a high or low workload. The results showed that an individual's perceptions of stress and mental fatigue decreased as a result of chewing gum. Depression and cognitive failures decreased as a result of experiencing a high workload. Perceptions of physical fatigue decreased when chewing gum under a high workload. The findings suggested that gum may be an effective way to reduce certain stress characteristics, and also reassuring students that a high workload is not necessarily detrimental to their wellbeing.

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Acute psychological stress alerts the adaptive immune response: Stress-induced mobilization of effector T cells

Cited by 51 publications

References 56 publications

Selective Mobilization of Cytotoxic Leukocytes by Epinephrine

Selective Mobilization of Cytotoxic Leukocytes by Epinephrine

Features of Immune Reactions in Stress Conditions Associated Associated With Exams

The Effects of Chewing Gum on Perceived Stress and Wellbeing in Students Under a High and Low Workload

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