Acute pulmonary oedema after tourniquet release

O’Leary, Anthony M.; Veall, G.; Butler, Patrick O.; Gm, Anderson

doi:10.1007/bf03006552

Cited by 31 publications

(10 citation statements)

References 5 publications

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“…Oxygen stress may induce MOF, which is clinically significant. Data from this and previous studies [23,24,[29][30][31][32][33][34][35][36] suggest that a number of clinical features of renal dysfunction in the presence or following PNP may in fact be due to low flow/reflow situations, and thus may relate to XO-derived radical oxygen species (ROS) activity, as demonstrated herein for the C8 mmHg groups. We have previously described the toxic effects of high XO activity in the lungs [23].…”

Section: Discussionmentioning

confidence: 54%

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

et al. 2008

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Background Physiologic renal changes associated with pneumoperitoneum (PNP) have been described and various underlying mechanisms have been suggested. We investigated the possibility that PNP-associated renal damage is pressure dependent, and that oxidative stress is thereby involved. Materials and methods Seventy Wistar rat kidneys (n = 10 per group) were isolated. They were perfused with oxygenated, warm, Krebs-Henseleit solution containing 5% albumin within an isolated environment and subjected to various CO 2 pressures (0 [control], 3,5,8,12,15, and 18 mmHg) for 60 min. Half of each group was additionally perfused for 30 min at 0 mmHg pressure.Results Renal flow decreased proportionately to the applied pressure as did urine output: both decreased (P \ 0.05) after 60 and 90 min when pressure C8 mmHg was applied. Oxygen extraction decreased (P \ 0.05) during PNP in all pressurized groups. Xanthine oxidase (XO) activity and reduced glutathione in the tissues increased (P \ 0.05) proportionately to pressures C8 mmHg. All parameters slightly reversed toward baseline values, upon the release of the intra-chamber pressure, except for the 18 mmHg group's values. Conclusions CO 2 -PNP pressure induces kidney injury, possibly reversible immediately after pressure is annulled. Pressure is associated with oxidative stress, which interferes with cellular metabolism and function, possibly via an ischemic-reperfusion-like mechanism.

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Section: Discussionmentioning

confidence: 54%

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

et al. 2008

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“…Furthermore, surgeons need to be aware of the risks associated with tourniquet use, which include skin damage, quadriceps muscle weakness, neuropraxia, vascular injury, or deep vein thrombosis. [42][43][44][45][46][47][48] To clarify the effects of tourniquet use, further studies are needed.…”

Section: Tourniquet Usementioning

confidence: 99%

Predicting Blood Loss in Total Knee and Hip Arthroplasty

Sizer

Cherian

Elmallah

et al. 2015

Orthopedic Clinics of North America

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“…Moreover, there are potential complications associated with tourniquet use: nerve palsy [8,19], delayed recovery of muscle power from microscopic changes in muscle myofibrils [21], wound complications [1,12,25], and venous thrombotic embolism [1,10,12]. Deflation of the tourniquet can cause respiratory and cardiac complications in patients with poor cardiac function [7,18].…”

Section: Introductionmentioning

confidence: 99%

Tourniquet Use During Cementation Only During Total Knee Arthroplasty: A Randomized Trial

Tarwala

Dorr

Gilbert

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background Total knee arthroplasty with the use of a tourniquet during the entire operation has not been shown to improve the performance of the operation and may increase the risk of complications. Questions/purposes We asked whether the limited use of a tourniquet for cementation only would affect (1) surgical time; (2) postoperative pain and motion of the knee; (3) blood loss; or (4) complications such as risk of nerve injuries, quadriceps dysfunction, and drainage compared with use of a tourniquet throughout the procedure. Methods Seventy-one patients (79 knees) were randomized to either use of a tourniquet from the incision through cementation of the implants and deflated for closure

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Acute pulmonary oedema after tourniquet release

Cited by 31 publications

References 5 publications

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

Predicting Blood Loss in Total Knee and Hip Arthroplasty

Tourniquet Use During Cementation Only During Total Knee Arthroplasty: A Randomized Trial

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