Acute Q fever and the risk of developing endocarditis

Martín-Aspas, Andrés; Collado-Pérez, C.; Vela-Manzano, L.; Álamo, C. Fernández Gutiérrez del; Racero, I. Tinoco; Giron-Gonzalez, JA

doi:10.1016/j.rceng.2015.01.003

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…[31][32][33] CONCLUSION This is the first study to document C. burnetii in humans in Jordan and it found that seroprevalence is high. Given that endocarditis has been reported as a chronic complication of Q-fever in several countries such as United States, 34 Canada, 35 and France, 36 it is likely that is also the case in Jordan. Considering Q fever infection in the differential diagnosis of endocarditis could be helpful as this condition can be improved with antibiotic treatment.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and Risk Factors for Coxiella burnetii in Jordan

Obaidat

Malania

Imnadze

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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This is the first cross-sectional study of the seroprevalence and risk factors for Coxiella burnetii in Jordan. A total of 781 individuals from 11 governorates of Jordan were tested by SERION ELISA classic C. burnetii IgG Phase 2. A validated and pretested questionnaire was used to collect risk factors and demographic data. The overall seroprevalence for C. burnetii was 24.2% (95% CI; 21.3-27.3%). Unadjusted odds ratios showed that governorate of residence, consumption of raw milk, and ownership of sheep, goats, and dogs were significantly (P £ 0.05) associated with C. burnetii seropositivity. The multivariate logistic regression showed that individuals who own small ruminants had three times greater odds of seropositivity than those who do not own a small ruminant, after controlling for age, gender, raw milk consumption, and ownership of dogs. In addition, individuals who live in Al-Karak, Az-Zarqa, and Al-Tafilah had significantly greater odds of seropositivity compared with individuals who live in the capital city, Amman (OR = 3.6, 4.8, and 2.7, respectively). This study suggests that preventive measures should be practiced in ruminant farms in Jordan to avoid C. burnetii infection. Coxiella burnetii should also be considered in the differential diagnosis of febrile-like illnesses in Jordan, especially among farmers and veterinarians.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence and Risk Factors for Coxiella burnetii in Jordan

Obaidat

Malania

Imnadze

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Q fever in Spain: Description of a new series, and systematic review

Alende-Castro¹,

Macía-Rodríguez

Novo-Veleiro³

et al. 2018

PLoS Negl Trop Dis

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BackgroundForms of presentation of Q fever vary widely across Spain, with differences between the north and south. In the absence of reported case series from Galicia (north-west Spain), this study sought to describe a Q-fever case series in this region for the first time, and conduct a systematic review to analyse all available data on the disease in Spain.MethodsPatients with positive serum antibodies to Coxiella burnetii from a single institution over a 5-year period (January 2011-December 2015) were included. Patients with phase II titres above 1/128 (or documented seroconversion) and compatible clinical criterial were considered as having Q fever. Patients with clinical suspicion of chronic Q-fever and IgG antibodies to phase I-antigen of over 1/1024, or persistently high levels six months after treatment were considered to be cases of probable chronic Q-fever. Systematic review: We conducted a search of the Pubmed/Medline database using the terms: Q Fever OR Coxiella burnetii AND Spain. Our search yielded a total of 318 studies: 244 were excluded because they failed to match the main criteria, and 41 were discarded due to methodological problems, incomplete information or duplication. Finally, 33 studies were included.ResultsA total of 155 patients, all of them from Galicia, with positive serological determination were located during the study period; 116 (75%) were deemed to be serologically positive patients without Q fever and the remaining 39 (25%) were diagnosed with Q fever. A potential exposure risk was found in 2 patients (5%). The most frequent form of presentation was pneumonia (87%), followed by isolated fever (5%), diarrhoea (5%) and endocarditis (3%). The main symptoms were headache (100%), cough (77%) and fever (69%). A trend to a paucisymptomatic illness was observed in women. Hospital admission was required in 37 cases, and 6 patients died while in hospital. Only 2 patients developed chronic Q-fever. Systematic review: Most cases were sporadic, mainly presented during the winter and spring, as pneumonia in 37%, hepatitis in 31% and isolated fever in 29.6% of patients. In the north of Spain, 71% of patients had pneumonia, 13.2% isolated fever and 13% hepatitis. In the central and southern areas, isolated fever was the most frequent form of presentation (40%), followed by hepatitis (38.4%) and pneumonia (17.6%). Only 31.7% of patients reported risk factors, and an urban-environment was the most frequent place of origin. Overall mortality was 0.9%, and the percentage of patients with chronic forms of Q-fever was 2%.ConclusionsThis is the first study to report on a Q-fever case series in Galicia. It shows that in this region, the disease affects the elderly population -even in the absence of risk factors- and is linked to a higher mortality than reported by previous studies. While pneumonia is the most frequent form of presentation in the north of the country, isolated fever and hepatitis tend to be more frequent in the central and southern areas. In Spain, 32% of Q-fever cases do not report con...

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Acute Q fever and the risk of developing endocarditis

Cited by 2 publications

References 22 publications

Seroprevalence and Risk Factors for Coxiella burnetii in Jordan

Seroprevalence and Risk Factors for Coxiella burnetii in Jordan

Q fever in Spain: Description of a new series, and systematic review

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