Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide

Larson, Abigail; Witman, Melissa A. H.; Guo, Yi; Ives, Stephen J.; Richardson, Russell S.; Bruno, Richard S.; Jalili, Thunder; Symons, J. David

doi:10.1016/j.nutres.2012.06.018

Cited by 86 publications

(83 citation statements)

References 31 publications

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“…It can further confirm that the ER stress pathway is involved in the beneficial effects of quercetin on glucosamine-induced HUVECs damage. Although animal studies have demonstrated a maximum concentration of 27.6 µM quercetin in mouse plasma (31), human clinical studies have observed a maximum plasma concentration of 5 µM (23,38). In the present study, 20 µM quercetin was identified as the concentration at which positive effects were observable.…”

Section: Discussionmentioning

confidence: 51%

“…In a study investigating the fate of quercetin, 14 C-quercetin was administered orally (100 mg, 330 µM) to healthy volunteers (44). The study observed that the oral absorption ranged from 36.4 to 53%, and the biological half-life was 20-72 h. The maximum concentration of quercetin in the plasma of mice has been demonstrated to be 27.6 µM (31), however, in certain population studies the highest concentration of quercetin in plasma was <5 µM (23,38). Further studies are, therefore, required to determine the pharmacokinetics of quercetin.…”

Section: Discussionmentioning

confidence: 99%

“…The concentration of quercetin used in previous in vitro studies into cardiovascular diseases ranged from 10-80 µM (30,35,37), while the highest concentration of quercetin observed in murine plasma was 27.6 µM (31). However, the highest concentration of quercetin observed in human plasma was 4.1 µM, which was observed 10 h after ingestion of 1,095 mg quercetin (38). Due to the limited availability of information regarding quercetin cell cytotoxicity, concentrations of 0, 5, 10, 20 and 50 µM quercetin were utilized in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine

Cai

Bao

Ding

et al. 2016

Molecular Medicine Reports

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Abstract.Glucosamine is a possible cause of vascular endothelial injury in the initial stages of atherosclerosis, through endoplasmic reticulum (ER) stress resulting in fatty streaks in the vascular wall. Quercetin is an anti-diabetic and cardiovascular protective agent that has previously been demonstrated to reduce ER stress in human umbilical vein endothelial cells (HUVECs). The present study aimed to investigate whether quercetin prevents glucosamine-induced apoptosis and inflammation via ER stress pathway in HUVECs. The effect of quercetin on cell viability, apoptosis, and protein expression levels of inflammatory cytokines and ER stress markers was investigated in glucosamine-supplemented HUVECs. Quercetin was demonstrated to protect against glucosamine-induced apoptosis, improved cell viability, and inhibited expression of pro-inflammatory factors and endothelin-1. Quercetin treatment also reduced the expression levels of glucose-regulated protein 78, phosphorylated protein kinase-like ER kinase, phosphorylated c-Jun N-terminal kinase and C/EBP homologous protein. In conclusion, quercetin may have auxiliary therapeutic potential against glucosamine-induced cell apoptosis and inflammation, which may be partially due to alleviation of ER stress. IntroductionDiabetes is a 'coronary heart disease (CHD) equivalent' disease, as epidemiological data has previously demonstrated that patients with diabetes without any prior evidence of CHD are at greater risk of death from CHD than nondiabetic patients with prior evidence of CHD (1,2). Atherosclerosis (AS) is a disease of arterial lipid deposition leading to a number of biological responses, including a chronic, macrophage-dominated inflammatory reaction (3), and is the pathological basis of CHD. The hexosamine biosynthesis pathway (HBP), a normal pathway for glucose metabolism, is activated excessively in patients with diabetes, resulting in increased cellular glucosamine (4). Endoplasmic reticulum (ER) is a membranous network to synthesize, modify, fold and assemble proteins. When the ER function, particularly folding capacity, is challenged, the unfolded protein response (UPR) is executed as a protective mechanism in ER. Failure of this mechanism to fold newly synthesized proteins shows unique damage to the cell and is termed ʻER stressʼ (5,6). Numerous studies have highlighted that ER stress may link hyperglycemia to AS (4,7,8). Important ER stress markers, including protein kinase-like ER kinase (PERK), glucose regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP), were expressed in the arterial wall of streptozotocin-induced hyperglycemic apolipoprotein (apoE)-deficient mice (4). Glucosamine levels and the expression of GRP78 were increased following hyperglycemia and prior to the early stages of fatty streak formation in aortic endothelial cells of hyperglycemic apoE -/-mice (7). In vitro studies have demonstrated that incubation of hepatic cells (9) and adipocytes (10) with 5 mM glucosamine resulted in lipid accumulation, impaired insulin-stimul...

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine

Cai

Bao

Ding

et al. 2016

Molecular Medicine Reports

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“…Quercetin is an antioxidant flavonol found in apples, berries and onions that reduces BP in hypertensive individuals [330,331] but the hypotensive effects do not appear to be mediated by changes in HSCRP, TNF-α, ACE activity, ET-1, NO, vascular reactivity or FMD [330] . Quercetin is metabolized by CYP 3A4.…”

Section: Alpha Lipoic Acidmentioning

confidence: 99%

“…Quercetin is metabolized by CYP 3A4. Quercetin was administered to 12 hypertensive men at an oral dose of 1095 mg with reduction in mean BP by 5 mmHg, SBP by 7 mmHg and DBP by 3 mmHg [330] . The maximal plasma level at 10 h was 2.3 ± 1.8 μmol/L, with return to baseline levels at 17 h. Forty one pre-hypertensive and stage Ⅰ hypertensive subjects were enrolled in a randomized, double-blind, placebo-controlled, crossover study with 730 mg of quercetin per day vs placebo [331] .…”

Section: Alpha Lipoic Acidmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Nanophytomedicine in Disease and Therapy

Upadhyay

Bhushan

Rudrapal

2022

Phytoantioxidants and Nanotherapeutics

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Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide

Cited by 86 publications

References 31 publications

Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine

Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Nanophytomedicine in Disease and Therapy

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