Acute rejection and late renal transplant failure: Risk factors and prognosis

Abstract

Despite a decreased incidence and severity of acute rejections in 1998, compared with the previous years, acute rejection still remains a powerful risk factor for late transplant failure.

Differential Effects of HNF-1α Mutations Associated with Familial Young-Onset Diabetes on Target Gene Regulation

“…Nan Lu, 1,2 Chuanxin Wang, 3 Xiaojing Yang, 3 Shengmei Zhao, 3 Xiangdong Li, 4 Xiaoli Li, 3 Hong Jiang, 5 Jinbo Feng, 5 Yi Zhang, 3* …”

“…However, acute graft rejection (AGR) is still considered to be a major factor influencing short-and long-term allograft survival (1,2). Rational immunosuppressive therapy (3) is another known posttransplantation issue.…”

Non-immunologic intervention in chronic allograft nephropathy

“…Immunologic factors include T-and B-cell recognition of alloantigens, cytomegalovirus infection, and endothelial cell activation followed by vascular smooth cell proliferation. The best evidence in support of the role of alloantigen-dependent factors in the development of chronic allograft dysfunction is the observation that its incidence increases after episodes of acute rejection, accompanied by inadequate immunosuppression and with increased human leukocyte antigen mismatching [3,4].…”

Complement C3 gene polymorphism in renal transplantation (an Iranian experience)

“…In spite of improving of immunosuppressive drugs, the rate of acute rejection is still about 15-20% (Ganji and Broumand, 2007;Pallardó Mateu et al, 2004).…”