Acute renal failure and lithium intoxication

Lavender, S.; Brown, Jaclyn N.; Berrill, W T

doi:10.1136/pgmj.49.570.277

Cited by 57 publications

(11 citation statements)

References 8 publications

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“…Lithium therapy is associated with multiple adverse renal effects, most frequently nephrogenic diabetes insipidus. Acute lithium intoxication is associated with AKI, with histologic findings of ATN (14). Chronic lithium toxicity, most commonly encountered after $10 years of therapy, is a distinctive chronic tubulointerstitial nephropathy (CTIN) characterized by distal tubular cysts (15,16).…”

Section: Lithiummentioning

confidence: 99%

Drug-Induced Glomerular Disease

Markowitz¹,

Bomback

Perazella

2015

Clinical Journal of the American Society of Nephrology

102

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The potential of medications to cause kidney injury is well known. Although nephrotoxicity is most commonly associated with injury in the tubulointerstitial compartment as either acute tubular necrosis or acute interstitial nephritis, a growing body of literature has also highlighted the potential for drug-induced glomerular lesions. This review surveys the three primary patterns of drug-induced glomerular diseases stratified by the cell type at which the glomerular lesion is focused: visceral epithelial cell (or podoctye) injury, endothelial cell injury, and mesangial cell injury. A number of commonly prescribed medications, including IFNs, bisphosphonates, nonsteroidal antiinflammatory drugs, antiplatelet agents, and antiangiogenesis drugs, that are both prescribed and available over the counter, have been implicated in these iatrogenic forms of glomerular disease. Recognition of these druginduced etiologies of glomerular disease and rapid discontinuation of the offending agent are critical to maximizing the likelihood of renal function recovery.

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Section: Lithiummentioning

confidence: 99%

Drug-Induced Glomerular Disease

Markowitz¹,

Bomback

Perazella

2015

Clinical Journal of the American Society of Nephrology

102

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“…Choreoathetosis is a rare complication of lithium therapy [4,6,15,18,24], With the first case described in 1949 [ 18] only 6 cases have been reported [4,6,15,18,24], The possible explanation of these movements in lithium therapy is supersensitivity of the dopaminer gic receptors in the basal ganglia [3].…”

Section: Discussionmentioning

confidence: 99%

Choreoathetosis as Toxic Effect of Lithium Treatment

Walevski¹,

Radwan²

1986

Eur Neurol

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“…The reported lithium half-life during HD was always shorter than that before and/or after dialysis, when it was calculated (18,70,71,97,110,111,149,193,202). Exact lithium removal by ECTR was quantified in several reports (usually using older dialysis technology) (56,62, 71,107,126,172,183,192,202) and shown to be significant, sometimes even in excess of 25 mEq/h (71).…”

Section: Dialyzabilitymentioning

confidence: 99%

Extracorporeal Treatment for Lithium Poisoning

Decker¹,

Goldfarb²,

Dargan³

et al. 2015

Clinical Journal of the American Society of Nephrology

150

139

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on behalf of the EXTRIP Workgroup Abstract The Extracorporeal Treatments in Poisoning Workgroup was created to provide evidence-based recommendations on the use of extracorporeal treatments in poisoning. Here, the EXTRIP workgroup presents its recommendations for lithium poisoning. After a systematic literature search, clinical and toxicokinetic data were extracted and summarized following a predetermined format. The entire workgroup voted through a two-round modified Delphi method to reach a consensus on voting statements. A RAND/UCLA Appropriateness Method was used to quantify disagreement, and anonymous votes were compiled and discussed in person. A second vote was conducted to determine the final workgroup recommendations. In total, 166 articles met inclusion criteria, which were mostly case reports, yielding a very low quality of evidence for all recommendations. A total of 418 patients were reviewed, 228 of which allowed extraction of patient-level data. The workgroup concluded that lithium is dialyzable (Level of evidence=A) and made the following recommendations: Extracorporeal treatment is recommended in severe lithium poisoning (1D).

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Acute renal failure and lithium intoxication

Cited by 57 publications

References 8 publications

Drug-Induced Glomerular Disease

Drug-Induced Glomerular Disease

Choreoathetosis as Toxic Effect of Lithium Treatment

Extracorporeal Treatment for Lithium Poisoning

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