Acute renal failure and oligohydramnios induced by magnesium dypirone (metamizol) in a pregnant woman

Nieta, María Dolores Sánchez de la; Rivera, Francisco; Torre, M. de la; Alcázar, Roberto; Caparrós, Guadalupe; Alcaide, Maria Paz; Vozmediano, Carmen; Sanchez, Antonio J.

doi:10.1093/ndt/gfg240

Cited by 15 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Concerning the overall risk of the long-term use of NOAs, cohort studies and meta-analyses could not identify a problematic safety profile for dipyrone, such as renal toxicity, despite few historic case reports. 2,[41][42][43][44] Instead, a meta-analysis published in 1997 reported an estimated excess mortality of 25 per 100 million for dipyrone compared to 592 per 100 million for NSAIDs. 42 The reasons for these findings are not clear, but it is known that dipyrone is relatively safe in terms of drug-drug interactions.…”

Section: Summary Of the Evidencementioning

confidence: 99%

See 1 more Smart Citation

Metamizole/dipyrone for the relief of cancer pain: A systematic review and evidence-based recommendations for clinical practice

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Summary Of the Evidencementioning

confidence: 99%

Metamizole/dipyrone for the relief of cancer pain: A systematic review and evidence-based recommendations for clinical practice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…On the other hand, there is an ongoing discussion on possible risks of long‐term use of paracetamol during gestation (eg,). Case reports on metamizole associated with findings similar to NSAIDs support the recommendation to avoid its use during the third trimester …”

Section: Introductionmentioning

confidence: 79%

Metamizole use during first trimester-A prospective observational cohort study on pregnancy outcome

Dathe

Padberg

Hultzsch

et al. 2017

Pharmacoepidemiol Drug Saf

View full text Add to dashboard Cite

show abstract

“…A case report of magnesium dypirone (metamizol), a nonsteroidal anti-in fl ammatory agent used as an analgesic and antipyritic, caused oligohydramnios and acute renal failure [ 56 ] . The patient took a high dose of this medication and her creatinine was 3.7 mg/dl.…”

Section: Interstitial Nephritismentioning

confidence: 99%

Pregnancy-Associated Kidney Injury

Anderson

Lannon

2012

Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation

View full text Add to dashboard Cite

A 23-year-old G1P0000 without prior past medical history is 31 weeks pregnant with prenatal care presents with complaints of worsening leg and face swelling for the past 2 days now seeks care because of headache, diarrhea, nausea, and vomiting. On exam she is found to have a blood pressure of 120/86, edema, and brisk deep tendon re fl exes. Laboratory testing revealed hemoglobin 11.3 g/dl, platelet count 141,000/ m l white blood count 18,000/ m l, creatinine 1.1 mg/dl, aspartate aminotransferases (AST) 65 U/l, lactate dehydrogenase (LDH) 400 U/l, total bilirubin 1.1 mg/dl, prothrombin time (PT) 14.7 s, ammonia of 90 mcg/dl, blood glucose 139 mg/dl, calcium 7.3 mg/dl, and uric acid of 6.0 mg/dl. The urinalysis demonstrated WBC's 3-5/hpf, RBC's 3-5/hpf-non-dysmorphic, renal tubular epithelial cells were seen and a urine protein to creatinine ratio of 2. One day after hospitalization the patient's blood pressure was 145/87 with a similar blood pressure 6 h later. Case 2A 38-year-old G4P2022 at 32 weeks gestational age who presents to clinic for her scheduled prenatal visit, and her blood pressure is found to be 147/92. Urine dip was negative for protein. She returned the following day with a 24 h urine collection which was negative for proteinuria again and her blood pressure was 156/94. She denied headache, vision changes, abdominal pain, or peripheral edema. Laboratory testing revealed hemoglobin 10 g/dl, platelet count 79,000, white blood count 13,270, creatinine 1.9 mg/dl, AST 92 U/l, and alanine aminotransferases (ALT) 120 U/l, and LDH of 672 U/l. A peripheral smear was signi fi cant for moderate shistocytes. The patient was admitted and given antenatal corticosteroids for fetal lung development in anticipation of preterm delivery. On hospital day 3, the patient developed severe right upper quadrant (RUQ) pain. Laboratory values were repeated and revealed hemoglobin 10.5 g/dl platelet count 85,000, white blood count 11,360, creatinine 1.8 mg/dl, AST 94, and ALT 98.

show abstract

Acute renal failure and oligohydramnios induced by magnesium dypirone (metamizol) in a pregnant woman

Cited by 15 publications

References 5 publications

Metamizole/dipyrone for the relief of cancer pain: A systematic review and evidence-based recommendations for clinical practice

Metamizole/dipyrone for the relief of cancer pain: A systematic review and evidence-based recommendations for clinical practice

Metamizole use during first trimester-A prospective observational cohort study on pregnancy outcome

Pregnancy-Associated Kidney Injury

Contact Info

Product

Resources

About