Acute renal failure due to the inhalation of organophosphates: successful treatment with haemodialysis

Rubio, Consolación Rosado; Fernández, Carmen Felipe; Bueno, Rosario Manzanedo; Pozo, Begoña Alaguero del; García, José Eugenio Soriano

doi:10.1093/ckj/sfs138

Cited by 12 publications

(12 citation statements)

References 6 publications

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“…ATN was seen in one of the 4 cases reflecting the possibility of renal affectation by the poison. Rubio et al [29] also documented this mode of presentation in a case report on OP poisoning. The pathogenesis of the ATN is unknown because of lack of experimental data.…”

Section: Risk Factors Identifiable In Our Cases Similar To Thosementioning

confidence: 82%

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Autopsy Findings in Cases of Suspected Pediatric Homicide

Atanda

2018

AJFSFM

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Pediatric deaths in developing countries, especially in Africa, are often attributed to supernatural causes or to aged family members or unfriendly neighbors. This study aims to evaluate autopsybased causes of death in such cases.All autopsy deaths in children less than 15 years of age in which homicide was suspected from January 2001 to December 2015 were retrospectively reviewed. Their bio-data, circumstances surrounding death and cause of death were extracted, and are presented in this report.In the 15 years reviewed, there were 55 pediatric homicide related cases. Based on autopsy findings (coupled with clinical and circumstantial evidences), manners of death were classified as natural (34%), accidental (31%), homicidal (9%) and unascertainable in the remaining 26% of the cases.The study highlights the need for forensic pathologists working in developing countries to be actively involved in all stages of investigating cases of suspected pediatric homicide.

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Section: Risk Factors Identifiable In Our Cases Similar To Thosementioning

confidence: 82%

“…The pathogenesis of the ATN is unknown because of lack of experimental data. In laboratory animals, finding of low urinary osmolality has suggested tubular dysfunction secondary to direct tubular damage or an increase in oxidative stress [29].…”

Section: Risk Factors Identifiable In Our Cases Similar To Thosementioning

confidence: 99%

Autopsy Findings in Cases of Suspected Pediatric Homicide

Atanda

2018

AJFSFM

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“…Full recovery after 10 days of hospitalization [5] A 23-year-old man with acute kidney injury due to OP Stabilization after multiple sessions of hemodyalisis combined with conventional treatment methods [6] Analysis of 8924 patients retropectively for kidney injury following OP poisoning in a10-year period After OP exposure, risk for AKI increases [7] A 58-year-old farmer with renal failure and metabolic acidosis following accidental OP exposure…”

Section: Resultsmentioning

confidence: 99%

“…Kidney injury is an understimated complication of OP poisoning particularly when combined with other intoxications [6]. When kidney injury occurs, hemodyalisis must be kept in mind [7]. In this review, we aimed to underline the importance of renal injury; a rare complication of OP poisoning.…”

Section: Organophosphatesmentioning

confidence: 99%

Association of Organophosphate Poisoning with Kidney Injury: A Mini Review

Erenler

Eser

Sarıaydın

et al. 2018

J. Nephrol. Urol. Res.

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Poisoning by Organophosphates is a public health problem particularly in developing countries. Although they are commonly used in agriculture as pesticides, unfortunately, their use as weapons in chemical warfare is not rare. Due to lack of control, they are usually available in stores. Individuals may be effected by these compounds either by accidents or suicidal attempts. Poisoning may ocur following peroral, inhalational or dermal intake. Due to structure of the compound (highly soluble), exposure by each route causes high morbidity and mortality. Organophosphates inhibit both acetylcholinesterase (AChE) and pseudocholinesterase. Inhibition of AChE results in accumulation of acetylcholine. This mechanism is the main reason for toxic effects. Toxic effects may present as muscarinic, nicotinic and central nervous system (CNS). Progression of the poisoning may be seen in three stages: cholinergic phase, intermediate syndrome and delayed neuropathy. Although cardiovascular, gastrointestinal, respiratory, ocular, musculoskeletal and CNS manfestations of the poisoning are well-described in the literature, its effects on renal system remains as a neglected field due to its scarcity. In this mini-review, our aim was to determine hazardous effects of OP poisoning on renal system and emphasize the importance of monitorization and early intervention.

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“…Acute kidney injury (AKI) is a sudden unexpected and sustained reduction of kidney function with several aetiologies and clinical presentations (Bellomo et al, 2001). Acute kidney injury was reported to be frequent in severe OP poisoning (Rubio et al, 2012). A study recorded 6.17-fold higher risk of AKI among OP patients (Lee et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Human kidney injury molecule-1 and interleukin-18 as predictive markers of nephrotoxicity in acute organophosphorus poisoned patients in Zagazig University hospitals

El-Sheikh¹,

Allam²

2018

J. Toxicol. Environ. Health Sci.

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Organophosphorus (OP) poisoning is a major common cause of mortality and morbidity in most countries. Some clinical cases developed renal injury after acute OP poisoning. The aim of our study is to evaluate the levels of kidney injury molecule-1(KIM-1) and interleukin-18(IL-18) in acute OP poisoned patients as early predictors of OP induced nephrotoxicity. Over a period of one year, the observational cross sectional study was conducted at the Poison Control Center, Zagazig University hospitals, Zagazig, Egypt. The study group consisted of 95 patients who fulfilled the inclusion criteria; the patients were categorized according to Peradeniya organophosphorus poisoning (POP) scale. The serum pseudocholine esterase enzyme (PChE), serum creatinine, urinary KIM-1 and IL-18 were assayed at 0, 12, 24 and 48 h after admission. There were progressive increases in the mean values of KIM-1 and IL-18 at different time intervals especially in severe poisoned patients compared to the increased levels of serum creatinine. The cutoff values of urinary KIM-1 and IL-18 that determined patients with potential AKI were 2.8 ng/ml creatinine (86.9% sensitivity, 94.6% specificity and 0.859% area under curve) and 59 pg/dl creatinine (90% sensitivity, 92% specificity and 0.946& area under curve), respectively. A positive correlation was observed between KIM-1 and IL-18 and serum creatinine. Moreover, KIM-1 is positively correlated with IL-18. Urinary KIM-1 and IL-18 may be considered as valid markers for prediction of acute kidney injury among acute OP poisoned patients.

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Acute renal failure due to the inhalation of organophosphates: successful treatment with haemodialysis

Cited by 12 publications

References 6 publications

Autopsy Findings in Cases of Suspected Pediatric Homicide

Autopsy Findings in Cases of Suspected Pediatric Homicide

Association of Organophosphate Poisoning with Kidney Injury: A Mini Review

Human kidney injury molecule-1 and interleukin-18 as predictive markers of nephrotoxicity in acute organophosphorus poisoned patients in Zagazig University hospitals

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