Acute renal failure in patients with acute pancreatitis: prevalence, risk factors, and outcome

Tran, Diep; Oe, P. L.; Fijter, C. W. H. de; Meulen, Jan van der; C, Ma

doi:10.1093/ndt/8.10.1079

Cited by 16 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite recent therapeutic progresses, they seem continuously to be associated with high morbidity and mortality rates [ 1 ]. Acute kidney injury (AKI), one of the major complications of MSAP and SAP, is associated with elevated in-hospital mortality and morbidity [ 2 ]. Recent studies have reported a fivefold increase in mortality of SAP patients with AKI (66.6%) after comparing with SAP patients without AKI (14.5%) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis

Jiajia

Liu

et al. 2022

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Background. Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 48 h) serum estradiol level is associated with AKI in patients with MSAP and SAP. Patients and Methods. We retrospectively collected data from patients with preliminary diagnosis of MSAP and SAP from the Affiliated Hospital of Yangzhou University between January 2014 and June 2018. Serum sex hormones were extracted for further assessment within first 48 h following admission. Logistic regression analysis and the receiving operating characteristic (ROC) curve were applied to evaluate the association and correlation between serum sex hormones and AKI. Results. Data from a total of 122 patients with MSAP or SAP were enrolled in this study. There were no differences in the incidence of AKI between males and females. However, comparing with patients without AKI, those with AKI saw higher estradiol level ( p ≤ 0.01 ) and slight higher progesterone level ( p = 0.014 ) but similar testosterone level ( p = 0.668 ). Interestingly, during both the manual selection and the stepwise backward logistic regression analysis, serum estradiol level was independently associated with AKI in patients with MSAP and SAP (OR 4.699, CI 1.783-12.386, and p = 0.002 ). Additionally, area under the curve of ROC (AUCROC) showed that serum estradiol level was a proper predictor for AKI (area under the curve 0.875). Specifically, the serum estradiol level of 223.15 pg/mL demonstrated a 92.3% sensitive and a 79.3% specificity in predicting AKI of MSAP and SAP patients, respectively. Conclusions. High baseline serum estradiol level appears to be an independent risk factor for AKI in patients with MSAP and SAP. It also tends to be an appropriate indicator for AKI.

show abstract

Section: Introductionmentioning

confidence: 99%

Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis

Jiajia

Liu

et al. 2022

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

Prognostic Stratification in Critically Ill Patients With Acute Renal Failure Requiring Dialysis

Chertow¹

1995

Arch Intern Med

349

179

View full text Add to dashboard Cite

Among critically ill patients, acute renal failure requiring dialysis is an ominous condition with a high risk of in-hospital mortality. This risk appears to depend largely on comorbid conditions, such as the need for mechanical ventilation and underlying malignancy. While this prognostic model requires prospective validation, it appears to identify a substantial fraction of patients for whom dialysis may be of limited or no benefit.

show abstract

Severe Pancreatitis

Malcynski¹

1996

Arch Surg

View full text Add to dashboard Cite

After hospital transfer to a teritiary referral center, only older age, use of inotropic and/or vasopressor support, and evidence of renal malfunction are associated with death. Prompt recognition of severe pancreatitis, especially in older patients, aggressive hemodynamic management, and/or earlier transfer to a tertiary care center may diminish the incidence of renal failure and mortality in severe pancreatitis.

show abstract

Acute renal failure in patients with acute pancreatitis: prevalence, risk factors, and outcome

Cited by 16 publications

References 0 publications

Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis

Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis

Prognostic Stratification in Critically Ill Patients With Acute Renal Failure Requiring Dialysis

Severe Pancreatitis

Contact Info

Product

Resources

About