Acute renal failure induced by carbon tetrachloride in rats with hepatic cirrhosis

Jaramillo-Juárez, Fernando; Rodríguez-Vázquez, María Luisa; Rincón-Sánchez, Ana Rosa; Martínez, M.C.; Ortíz, Genaro Gabriel; Llamas, Javier; Posadas, Francisco; Reyes, José L.

doi:10.1016/s1665-2681(19)31833-2

Cited by 50 publications

(26 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44 Increased serum urea and creatinine levels indicate impairment to kidney functions such as acute glomerulonephritis, nephrosclerosis and even tubular necrosis. 45 Therefore, NVP at the two doses administered did not interfere with the renal functions in the animals. This observation was supported by results from the histopathological slides from kidneys of the animals.…”

Section: Discussionmentioning

confidence: 86%

Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats

et al. 2011

View full text Add to dashboard Cite

We investigated the toxic effect of nevirapine (NVP; Viramune(®)), an antiretroviral drug, on the liver, kidney and testis of Wistar rats. Twenty-one rats were assigned into 3 groups of 7 animals each. The first group served as control, and the second and third groups received NVP at 18 and 36 mg/kg body weight, respectively. Clinical signs of toxicity were not observed in the animals. NVP at both doses did not significantly (p > 0.05) alter the body weight gain, relative weights of kidney and testis, serum protein, urea, creatinine and alkaline phosphatase levels of the animals. However, NVP2 significantly (p < 0.05) increased the relative weight of liver, level of serum total bilirubin and activities of γ-glutamyl transferase, alanine and aspartate aminotransferases. NVP administration caused a dose-dependent, significant (p < 0.05) elevation of lipid peroxidation measured as malondialdehyde (MDA) content in the liver, kidney and testis of the rats. Hepatic, renal and testicular MDA were increased by 107%, 80% and 163%, respectively, in NVP2-treated rats. Elevation in MDA was accompanied by a significant (p < 0.05) decrease in the activities of hepatic, renal and testicular superoxide dismutase and catalase. NVP2 caused 43% and 32% decrease in spermatozoa motility and live/dead sperm count, respectively, and 94% increase in total sperm abnormalities. Histopathological findings showed that NVP2 caused degeneration of seminiferous tubules in testis, and severe necrosis in liver slides. NVP induced oxidative stress with corresponding decrease in antioxidant status of the rats. The changes in sperm parameters and, elevation of liver marker enzymes suggest an interference of NVP2 with these organs.

show abstract

Section: Discussionmentioning

confidence: 86%

Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The mechanism of CCl 4 renal toxicity is almost the same as that of liver, but CCl 4 shows a high affinity to the kidney cortex which contains cytochrome P-450 predominantly [34, 35]. Due to CCl 4 hepatorenal injury, the transport function of hepatocytes and nephrotic cells gets disturbed resulting in the leakage of plasma membrane, thereby causing an increased enzyme level in the serum [36].…”

Section: Discussionmentioning

confidence: 99%

Attenuation of CCl₄-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats

Al-Yahya

Mothana

Alsaid

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The present study was undertaken to investigate the possible protective effect of Saudi Sidr honey (SSH) on carbon tetrachloride (CCl4) induced oxidative stress and liver and kidney damage in rat. Moreover, the antioxidant activity and the phenolic and flavonoidal contents were determined. The hepatorenal protective activity of the SSH was determined by assessing biochemical, hematological, and histological parameters. Serum transaminases, ALP, GGT, creatinine, bilirubin urea, uric acid, and MDA level in liver and kidney tissues were significantly elevated, and the antioxidant status of nonprotein sulfhydryls, albumin, and total protein levels in liver and kidney were declined significantly in CCl4 alone treated animals. Pretreatment with SSH and silymarin prior to the administration of CCl4 significantly prevented the increase of the serum levels of enzyme markers and reduced oxidative stress. SSH also exhibited a significant lipid-lowering effect and caused an HDL-C enhanced level in serum. The histopathological evaluation of the liver and kidney also revealed that honey protected incidence of both liver and kidney lesions. Moreover, SSH showed a strong antioxidant activity in DPPH and β-carotene-linoleic acid assays. SSH was found to contain phenolic compounds. Additionally, the SSH supplementation restored the hepatocytes viability against 2′,7′-dichlorofluorescein (DCF) toxicity in ex vivo test.

show abstract

“…These results may indicate an increase in the release of the liver enzyme in the blood stream [39]. The concurrent administration of honey and melamine showed improvement in renal and hepatic tissues.…”

Section: Discussionmentioning

confidence: 99%

Bees' Honey Protects the Liver of Male Rats against Melamine Toxicity

Rabey

Al‐Seeni

Al-Solamy

2013

BioMed Research International

View full text Add to dashboard Cite

The protective effect of natural bees' honey to the liver of male albino rats against melamine toxicity was studied. Melamine supplementation at a dose of 20000 ppm in the diet for 28 days induced adverse effects on the liver, decreased serum total protein and increased liver enzyme: alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Histological changes of the melamine supplemented group showed necrosis in the hepatic tissues around the central veins of the liver and precipitation of melamine crystals. Treating the male albino rats (that were presupplemented regularly with 20000 ppm melamine) with natural bees' honey at a dose of 2.5 g/kg body weight for 28 days improved both liver functions and increased serum protein. In addition, a positive impact on the shape of the cells after treatment with honey compared to the positive melamine supplemented group was observed. In conclusion, the results of this study revealed that the use of natural bees' honey has the ability to protect the liver of rats against the toxic effects of melamine.

show abstract

Acute renal failure induced by carbon tetrachloride in rats with hepatic cirrhosis

Cited by 50 publications

References 31 publications

Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats

Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats

Attenuation of CCl₄-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats

Bees' Honey Protects the Liver of Male Rats against Melamine Toxicity

Contact Info

Product

Resources

About

Acute renal failure induced by carbon tetrachloride in rats with hepatic cirrhosis

Cited by 50 publications

References 31 publications

Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats

Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats

Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats

Bees' Honey Protects the Liver of Male Rats against Melamine Toxicity

Contact Info

Product

Resources

About

Attenuation of CCl₄-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats