Acute renal failure owing to paraphenylene diamine hair dye poisoning in Sudanese children

Abdelraheem, Mohamed; El-Tigani, M. A. A.; Hassan, E. G.; Ali, Mohsin; Mohamed, I. A.; Nazik, Allali

doi:10.1179/027249309x12467994693815

Cited by 32 publications

(31 citation statements)

References 18 publications

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“…In our study, the overall incidence of renal failure was 58.46% while Abdelrheem MB et al showed renal failure in 71%. 10,11 The moratlity rate in our study was 21.53% which is comparable to Ayoub Filali et al and Osman et al 3,12 CONCLUSION PPD containing hair dye is a great hazard and its use has been banned in countries like Germany, France and Sweden. However in India it is still commonly used in many parts and needs to be banned.…”

Section: Discussionsupporting

confidence: 77%

Study of hair dye poisoning and its outcome in tertiary care rural institute

Rawat¹,

Kumar²,

Singh³

et al. 2016

Int J Res Med Sci

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Section: Discussionsupporting

confidence: 77%

Study of hair dye poisoning and its outcome in tertiary care rural institute

Rawat¹,

Kumar²,

Singh³

et al. 2016

Int J Res Med Sci

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“…of plots for bleeding time (n = 8); *P < 0.05 versus Control. Abdelraheem et al, 2009). We therefore suggest that PPDprimed platelets are predisposed to form a platelet thrombus.…”

Section: Discussionmentioning

confidence: 99%

Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

et al. 2016

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-Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product.

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“…PPD allergy can present with relatively rare skin manifestations, which are described in case reports, such as erythema multiforme,22 severe inflammatory, keloidal allergic reaction,23 contact urticaria,24 systemic manifestations such as acute renal failure,25 and even anaphylaxis 26…”

Section: Clinical Presentationmentioning

confidence: 99%

Para-phenylenediamine allergy: current perspectives on diagnosis and management

Mukkanna¹,

Stone²,

Ingram³

2017

JAA

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Para-phenylenediamine (PPD) is the commonest and most well-known component of hair dyes. Oxidative hair dyes and dark henna temporary tattoos contain PPD. Individuals may be sensitized to PPD by temporary henna tattooing in addition to dyeing their hair. PPD allergy can cause severe reactions and may result in complications. In recent years, frequency of positive patch test reactions to PPD has been increasing. Cross-sensitization to other contact allergens may occur, in particular to other hair dye components. Hairdressers are at a high risk for PPD allergy and require counseling regarding techniques to minimize exposure and protective measures while handling hair dye. We focus this review on the current perspectives of diagnosis and management of PPD allergy.

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Acute renal failure owing to paraphenylene diamine hair dye poisoning in Sudanese children

Abstract: PPD intoxication is a life-threatening condition with significant morbidity and mortality in children. Clinical manifestations and outcome are similar to those in adults. Mortality can be reduced by early recognition, prompt referral and aggressive supportive treatment.

Cited by 32 publications

References 18 publications

Study of hair dye poisoning and its outcome in tertiary care rural institute

Study of hair dye poisoning and its outcome in tertiary care rural institute

Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

Para-phenylenediamine allergy: current perspectives on diagnosis and management

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