Acute Renal Vein Thrombosis, Oral Contraceptives, and Protein S Deficiency: A Successful Catheter-Directed Thrombolysis

Catheter‐directed therapy for acute renal vein thrombosis in systemic lupus erythematosus: A case report

“…After recanalization, an overnight infusion of a thrombolytic agent through an infusion catheter directly to the occluded vessel further dissolves the thrombus. This management protocol was reported in a case series consisting of seven thrombosed renal veins in six patients, with a success rate of 100% that restored renal vein flow, with no complications such as pulmonary embolisms and hemorrhagic complications . No bleeding requiring transfusion occurred, and no additional surgical treatment was necessitated in our case.…”

“…With limited data, systemic thrombolytics in patients with RVT had a high bleeding complication rate: 42% (3 hemorrhagic complications in 7 patients) . With real‐time ultrasound puncture, improved CDT device, and techniques, the CDT complication rate is lowered to minimal as Kim et al reported (no bleeding or pulmonary embolism in six patients) . It is the time to reconsider aggressive treatment for this group of patients who presented with acute renal failure and failed to respond to initial anticoagulation.…”

A Case of Proteinuria Developing Secondary to Solitary Renal Vein Thrombosis Due to Oral Contraceptive Use

“…Several case series in the literature have reported patients with RVT associated with hyperhomocysteinemia, elevated factor VIII levels, congenital disabilities of clotting inhibitors such as potential heterozygous true deficiencies of antithrombin III (low ATIII antigen and activity), a decreased protein C antigen to factor X antigen ratio, a heparin cofactor II deficiency, and a type I protein S deficiency after oral contraceptive use. [6][7][8][9] In our case, heterozygous MTHFR c.677C>T mutation was positive. This heterozygous mutation generally increases the susceptibility to arterial thrombosis.…”