Acute Respiratory Disease in Military Trainees

Dudding, Burton A.; Top, Franklin H.; Winter, Phillip E.; Buescher, Edward L.; Lamson, Thomas H.; Leibovitz, Albert

doi:10.1093/oxfordjournals.aje.a121499

Cited by 93 publications

(35 citation statements)

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“…In addition to serotype-4, serotypes 7, 21, and 3 were commonly seen in the pre-vaccine era [9,15,45]. The small proportion of serotype-3 currently present is randomly distributed over all recruit training centers.…”

Section: Discussionmentioning

confidence: 99%

“…With the discovery and characterization of adenoviruses in 1953 [5,6], and subsequent demonstration of seroconversion to this virus among those symptomatic [7], up to 70% of respiratory illness in recruits was finally linked to an etiologic agent [8][9][10][11][12][13]. Adenovirus serotypes 4 and 7 were recognized as the most important strains responsible for respiratory disease in recruit populations [9,[13][14][15]. In addition to the morbidity and occasional mortality suffered by the recruits, distraction from the regimented training program was recognized as mission compromising and costly to the US government.…”

Section: Introductionmentioning

confidence: 99%

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Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Russell

Hawksworth

Ryan

et al. 2006

Vaccine

128

109

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Background and Methods: The high burden of respiratory infections in military populations is well documented throughout history. The primary pathogen responsible for morbidity among US recruits in training was shown to be adenovirus. Highly efficacious oral vaccines were used for 25 years, but vaccine production ceased in 1996, and available stores were depleted by early 1999. Surveillance for acute febrile respiratory illness was performed at eight military recruit training sites throughout the United States from July 1999 through June 2004 to document rates after loss of the vaccines. Laboratory diagnoses complimented the surveillance efforts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Russell

Hawksworth

Ryan

et al. 2006

Vaccine

128

109

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“…In the United States, Ad 4 and Ad7 were the most frequently associated with ARDS [Dudding et al, 1973], followed by Ad21 and Ad3. In Asia and Europe, Ad 3, Ad14, and Ad21 were more frequently reported [Tai et al, 1960].…”

Section: Introductionmentioning

confidence: 99%

Type‐specific identification of human adenovirus 3, 7, and 21 by a multiplex PCR assay†

Erdman

2001

Journal of Medical Virology

123

137

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Human adenovirus (Ad) serotypes 3, 7, and 21 of DNA cluster B:1 are often associated with severe respiratory illness, particularly in infants and young children and, in addition to Ad4, are among the most important causes of acute respiratory disease syndrome in new military recruits. To address the inherent problems associated with classic typing methods, we developed a multiplex PCR assay for the rapid, specific identification of Ad3, Ad7, and Ad21 field isolates. To design type-specific primers for our assay, we sequenced the Ad21 hexon gene and compared this sequence with previously published sequences of Ad3, Ad7, and Ad16. The overall nucleotide (nt) and amino acid (aa) identities between Ad21 and Ad3, Ad7, and Ad16 were similar (ranges 78.3-80.8% nt; 84.1-86.2% aa), with significantly greater variability in the regions of the hexon that encode surface loops 1 and 2. Type-specific primers designed to the hypervariable regions correctly identified Ad3, Ad7, and Ad21 prototype strains and 53 previously typed Ad field isolates. No cross-reactions with other Ad serotypes were identified. Our multiplex PCR assay for type-specific identification of Ad3, Ad7, and Ad21 isolates will provide a rapid and convenient tool for the epidemiologic investigation of Ad-associated respiratory illness.

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“…Human adenovirus (HAdV) infections have been recognized for decades as being important causes of ARD among military trainees in North America, Europe, and Asia (5,8,10,15,25,27,30,32). The HAdV serotypes most frequently associated with ARD in both military and civilian communities include subspecies B1 HAdV-3, HAdV-7, and HAdV-21 and species E HAdV-4.…”

mentioning

confidence: 99%

Outbreak of Febrile Respiratory Illness Associated with Adenovirus 11a Infection in a Singapore Military Training Camp

et al. 2010

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Acute Respiratory Disease in Military Trainees

Cited by 93 publications

References 0 publications

Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Type‐specific identification of human adenovirus 3, 7, and 21 by a multiplex PCR assay†

Outbreak of Febrile Respiratory Illness Associated with Adenovirus 11a Infection in a Singapore Military Training Camp

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