Acute respiratory distress caused by Neosartorya udagawae

Farrell, John; Kasper, Douglas J.; Taneja, Deepak; Baman, Sudhakar; O׳Rourke, Lindsay M.; Lowery, Kristin S.; Sampath, Rangarajan; Peterson, Stephen W.

doi:10.1016/j.mmcr.2014.07.003

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Recently, a series of species genetically related to A. fumigatus have been isolated in clinical practice to determine the importance of these species [4][5][6][7] . The following A. fumigatus-related species have been isolated in clinical settings: Aspergillus aureoles, Aspergillus felis, Aspergillus hiratsukae, Aspergillus lentulus, Aspergillus pseudoviridinutans, Aspergillus thermomutatus, Aspergillus udagawae, Aspergillus viridinutans, and Aspergillus wyomingensis 6,[8][9][10][11][12][13][14][15][16] . These species, except A. hiratsukae, A. thermomutatus, and A. lentulus, are included in the series Viridinutantes proposed by Houbraken et al 17) .…”

Section: Introductionmentioning

confidence: 99%

Ubiquitous Distribution of Azole-Resistant <i>Aspergillus fumigatus</i>- Related Species in Outdoor Environments in Japan

Watanabe

Yaguchi

Hirose

2021

Medical Mycology Journal

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Aspergillus fumigatus-related species are responsible for causing aspergillosis, which is a fatal infectious disease. Recently, there has been a series of reports of A. fumigatus-related species that are resistant to azole drugs used in clinical practice for the treatment of fungal infections. Some of these species have been isolated from outdoor environments. Testing the drug susceptibility of the strains from outdoor environments, therefore, is important. In this study, we isolated and cultured 72 strains of A. fumigatus-related species from the outdoor environment in Japan. The isolates identified via morphological observation and molecular phylogenetic analysis were Aspergillus felis, Aspergillus lentulus, Aspergillus pseudoviridinutans, Aspergillus udagawae, and Aspergillus wyomingensis. The results of the drug susceptibility testing revealed that A. felis (6 of 14 strains) and A. pseudoviridinutans (13 of 17 strains) were resistant to itraconazole (ITCZ), with 4 mg/L or higher minimum inhibitory concentrations (MICs). The voriconazole (VRCZ)-resistant strains with 4 mg/L or higher MICs were A. felis (14 of 14), A. lentulus (4 of 4), A. pseudoviridinutans (15 of 17), A. udagawae (23 of 34), A. wyomingensis (1 of 3), and A. pseudoviridinutans (1 of 3). Among them, A. felis (1 of 14) and A. pseudoviridinutans (7 of 17) demonstrated 8 mg/L or higher MICs for ITCZ and VRCZ. These results indicate that A. fumigatus-related species resistant to ITCZ and VRCZ are widely distributed in outdoor environments in Japan.

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Section: Introductionmentioning

confidence: 99%

Ubiquitous Distribution of Azole-Resistant <i>Aspergillus fumigatus</i>- Related Species in Outdoor Environments in Japan

Watanabe

Yaguchi

Hirose

2021

Medical Mycology Journal

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“…A comparable situation arose with Neosartorya udagawae , which is also often mistaken for A. fumigatus . In 2014, it was reported to cause acute respiratory distress syndrome (ARDS) in a 43-year-old woman [ 38 ]. It was distinguished by sequencing ITS, calmodulin and β-tubulin genes.…”

Section: Two Sides Of the Same Coinmentioning

confidence: 99%

Soil-Borne Neosartorya spp.: A Heat-Resistant Fungal Threat to Horticulture and Food Production—An Important Component of the Root-Associated Microbial Community

Maj

Pertile

Frąc

2023

IJMS

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Soil-borne Neosartorya spp. are the highly resilient sexual reproductive stage (teleomorph) of Aspergillus spp. Fungi of this genus are relevant components of root-associated microbial community, but they can also excrete mycotoxins and exhibit great resistance to high temperatures. Their ascospores easily transfer between soil and crops; thus, Neosartorya poses a danger to horticulture and food production, especially to the postharvest quality of fruits and vegetables. The spores are known to cause spoilage, mainly in raw fruit produce, juices, and pulps, despite undergoing pasteurization. However, these fungi can also participate in carbon transformation and sequestration, as well as plant protection in drought conditions. Many species have been identified and included in the genus, and yet some of them create taxonomical controversy due to their high similarity. This also contributes to Neosartorya spp. being easily mistaken for its anamorph, resulting in uncertain data within many studies. The review discusses also the factors shaping Neosartorya spp.’s resistance to temperature, preservatives, chemicals, and natural plant extracts, as well as presenting novel solutions to problems created by its resilient nature.

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“…Neosartorya spp., teleomorph of A. fumigatus , are a cause of invasive disease in immunocompromised patients [ 49 ]. Acute respiratory distress syndrome has been attributed to N. udagawae [ 50 ]. The structure [→6)-Gal f (β1→5)-Gal f (β1→5)-D-Gal f (β1→] has been determined in polysaccharides of some species of Neosartorya [ 36 ].…”

Section: β-Galactofuranosyl Structures In Human Infective Fungimentioning

confidence: 99%

Galactofuranose Antigens, a Target for Diagnosis of Fungal Infections in Humans

2017

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The use of biomarkers for the detection of fungal infections is of interest to complement histopathological and culture methods. Since the production of antibodies in immunocompromised patients is scarce, detection of a specific antigen could be effective for early diagnosis. D-Galactofuranose (Galf) is the antigenic epitope in glycoconjugates of several pathogenic fungi. Since Galf is not biosynthesized by mammals, it is an attractive candidate for diagnosis of infection. A monoclonal antibody that recognizes Galf is commercialized for detection of aspergillosis. The linkage of Galf in the natural glycans and the chemical structures of the synthesized Galf-containing oligosaccharides are described in this paper. The oligosaccharides could be used for the synthesis of artificial carbohydrate-based antigens, not enough exploited for diagnosis.

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Acute respiratory distress caused by Neosartorya udagawae

Cited by 7 publications

References 5 publications

Ubiquitous Distribution of Azole-Resistant <i>Aspergillus fumigatus</i>- Related Species in Outdoor Environments in Japan

Ubiquitous Distribution of Azole-Resistant <i>Aspergillus fumigatus</i>- Related Species in Outdoor Environments in Japan

Soil-Borne Neosartorya spp.: A Heat-Resistant Fungal Threat to Horticulture and Food Production—An Important Component of the Root-Associated Microbial Community

Galactofuranose Antigens, a Target for Diagnosis of Fungal Infections in Humans

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