Acute respiratory distress syndrome and blastomycosis: Presentation of nine cases and review of the literature

Lemos, Luciano B.; Baliga, Mithra; Guo, Ming

doi:10.1053/adpa.2001.21473

Cited by 78 publications

(52 citation statements)

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“…Miliary blastomycosis or endobronchial spread of infection can cause the adult respiratory distress syndrome (ARDS) with diffuse bilateral pulmonary infiltrates and noncardiogenic pulmonary edema (3,71,83). ARDS caused by pulmonary blastomycosis is associated with high mortality (83).…”

Section: Pulmonary Blastomycosismentioning

confidence: 99%

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Clinical and Laboratory Update on Blastomycosis

2010

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SUMMARY Blastomycosis is endemic in regions of North America that border the Great Lakes and the St. Lawrence River, as well as in the Mississippi River and Ohio River basins. Men are affected more often than women and children because men are more likely to participate in activities that put them at risk for exposure to Blastomyces dermatitidis. Human infection occurs when soil containing microfoci of mycelia is disturbed and airborne conidia are inhaled. If natural defenses in the alveoli fail to contain the infection, lymphohematogenous dissemination ensues. Normal host responses generate a characteristic pyogranulomatous reaction. The most common sites of clinical disease are the lung and skin; osseous, genitourinary, and central nervous system manifestations follow in decreasing order of frequency. Blastomycosis is one of the great mimickers in medicine; verrucous cutaneous blastomycosis resembles malignancy, and mass-like lung opacities due to B. dermatitidis often are confused with cancer. Blastomycosis may be clinically indistinguishable from tuberculosis. Diagnosis is based on culture and direct visualization of round, multinucleated yeast forms that produce daughter cells from a single broad-based bud. Although a long course of amphotericin B is usually curative, itraconazole is also highly effective and is the mainstay of therapy for most patients with blastomycosis.

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Section: Pulmonary Blastomycosismentioning

confidence: 99%

“…ARDS caused by pulmonary blastomycosis is associated with high mortality (83). In a series from Mississippi, 9 (ϳ8%) of 107 patients with pulmonary blastomycosis had ARDS, and 7 (78%) of this number died of respiratory failure over a median course of about a week (71).…”

Section: Pulmonary Blastomycosismentioning

confidence: 99%

Clinical and Laboratory Update on Blastomycosis

2010

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“…Заражение происходит ингаляционным пу тем, течение заболевания может быть острым, подост рым или хроническим. Редко заболевание протекает как острый респираторный дистресс синдром (ОРДС) с фулминантной диффузной пневмонией [54]. Чаще встречаются менее тяжелые формы бластомикоза в виде лобарной пневмонии, объемных образований, одиночных или множественных очагов и хроничес ких фиброзно нодулярных или фиброзно деструк тивных изменений.…”

Section: лечение бластомикоза введениеunclassified

Treatment of fungal infections in adult pulmonary and critical care patients

Лимпер¹,

Нокс²,

Сарози³

et al. 2011

Pulʹmonologiâ (Mosk.)

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“…12 ARDS caused by pulmonary blastomycosis is associated with high mortality. 13 In a series from Mississippi, 9 of 107 patients with pulmonary blastomycosis had ARDS; 78% of these died.…”

mentioning

confidence: 99%

“…13 In a series from Mississippi, 9 of 107 patients with pulmonary blastomycosis had ARDS; 78% of these died. 12 When blastomycosis does occur in immunocompromised patients, the disease is more aggressive than in immunocompetent hosts. In one series, 30% of patients died of blastomycosis, disseminated disease and involvement of the CNS were relatively common.…”

mentioning

confidence: 99%