2022
DOI: 10.1101/2022.08.02.22278344
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Acute respiratory distress syndrome and shunt detection with bubble studies: a systematic review and meta-analysis

Abstract: Objectives: Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory injury with multiple physiological sequalae. Shunting of deoxygenated blood through intra and extra-pulmonary shunts is one consequence that may complicate ARDS management. Therefore, we conducted a systematic review to determine the prevalence of sonographically detected shunt and its association with oxygenation and mortality in patients with ARDS. Data Sources: We searched MEDLINE, EMBASE, Cochrane Library and DARE dat… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

2
1
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
1

Relationship

1
0

Authors

Journals

citations
Cited by 1 publication
(3 citation statements)
references
References 29 publications
2
1
0
Order By: Relevance
“…In this study, COVID-19 shunt rates were not significantly different compared to non-COVID ARDS. Our findings align with the recent meta-analysis, 12 suggesting approximately ∼1 in 5 patients with ARDS had a R-L shunt. We also found an association between R-L shunts and increased hospital mortality, but this was no longer significant at 90-day mortality, or after multivariable adjustment.…”
Section: Discussionsupporting
confidence: 93%
See 2 more Smart Citations
“…In this study, COVID-19 shunt rates were not significantly different compared to non-COVID ARDS. Our findings align with the recent meta-analysis, 12 suggesting approximately ∼1 in 5 patients with ARDS had a R-L shunt. We also found an association between R-L shunts and increased hospital mortality, but this was no longer significant at 90-day mortality, or after multivariable adjustment.…”
Section: Discussionsupporting
confidence: 93%
“…We investigated different shunt types, co-interventions, and duration of mechanical ventilation plus other respiratory adjuncts, which is not routinely reported in ARDS literature. 12 Our study reinforces the safety of intensivist and trainee TEE, given that there were no procedural complications, 31 and our inter-relator scores highlight that ICU echocardiography and TCD is feasible and reliable. 32,33 We performed both unadjusted and adjusted ORs analysis using multivariable logistic regression to account for known confounders (e.g age, illness severity), in keeping with STROBE and Newcastle-Ottawa score recommendations.…”
Section: Discussionsupporting
confidence: 74%
See 1 more Smart Citation