Acute respiratory distress syndrome in a man with Epstein–Barr virus infection-induced hypocomplementemic urticarial vasculitis

Tsai, Chun-Chou; Lin, Chia‐Hua; Wang, Yung-Chih; Chang, Feng–Yee

doi:10.1016/j.jfma.2018.01.022

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…Anti-C1q circulating antibodies are found in more than half of the patients and are, along with low C1q levels, considered to be the marker of the disease [ 5 , 6 , 11 , 12 ]. Apart from these, other factors that could possibly activate C1q are drugs, like the anti-TNF factor etanercept [ 14 ], viruses, like Epstein-Barr and Hepatits B,C [ 15 ] and other, non-identified autoantibodies [ 15 , 16 ]. Unfortunately, we could not test for anti-C1q antibodies, as the assay is not available not only in out hospital, but in any public laboratory in Greece.…”

Section: Discussionmentioning

confidence: 99%

A case report of hypocomplementemic urticarial vasculitis presenting with membranoproliferative glomerulonephritis

et al. 2020

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Background: Hypocomplementemic urticarial vasculitis syndrome is an infrequent condition characterized by ocular, renal, gastrointestinal and pulmonary involvement with low serum complement levels and autoantibodies. Renal manifestations vary from microscopic hematuria to nephrotic syndrome and acute kidney injury. Accordingly differing histologic patterns have been reported. Case presentation: We present the case of a 65 years old woman with a history of chronic uveitis who presented with arthralgias, urticarial rush, nephrotic syndrome, glomerular hematuria and low serum complement. Kidney biopsy revealed an immune-complex membranoproliferative glomerulonephritis. The patient received induction therapy with steroids, cyclophosphamide and hydroxychloroquine followed by rapid clinical improvement and remission of proteinuria. Maintenance treatment consisted of rituximab pulses. Conclusions: The majority of hypocomplementemic urticarial vasculitis syndrome cases is idiopathic, although an association to drugs, infections or other autoimmune disorders has been recorded. Given the rarity and heterogeneity of the disease, no standard treatment is established.

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