Acute Respiratory Distress Syndrome: New Classification

Abstract

The article deals with acute respiratory distress-syndrome new classification which was developed at the V.A. Negovsky Research Institute of General Reanimatology (Moscow, Russia). This classification makes it possible to timely diagnose early stages of acute respiratory distress-syndrome by means of transpulmonary thermodilution method.

Diagnosis of Acute Respiratory Distress Syndrome in Nosocomial Pneumonia

“…First, the Murray lung injury score (published 1988) 10 and the American-European Consensus Conference on ARDS (published 1992) criteria 11 were used. Second, after obtaining data regarding transpulmonary thermodilution within 1 to 2 hours, the aforementioned criteria were compared with the ARDS criteria of the V. A. Negovsky Research Institute of General Reanimatology (published 2006; see the appendix), 1,12,13 and the patients were reclassified. In patients diagnosed with ARDS, the stage of ARDS was determined according to the classification of the V. A. Negovsky Research Institute of General Reanimatology (published 2007).…”

“…In patients diagnosed with ARDS, the stage of ARDS was determined according to the classification of the V. A. Negovsky Research Institute of General Reanimatology (published 2007). 1 The diagnosis of sepsis was made according to standard criteria. 14 All patients underwent the following investigation protocol: APACHE II scoring on day 1; daily physical examinations, assessment of blood gases, central hemodynamics, extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI), fluid balance, ventilatory parameters, and total blood count.…”

“…According to the classification of acute respiratory distress syndrome (ARDS) 1 that was developed at the V. A. Negovsky Research Institute of General Reanimatology, there are 3 phases of ARDS: reversible acute lung injury, progressive respiratory insufficiency, and a terminal phase. Nosocomial pneumonia (NPn) constitutes up to 20% of all pneumonias in intensive care units (ICUs) and is associated with greater than 70% mortality.…”

Surfactant Proteins A and D – New Diagnostic and Prognostic Biomarkers of Acute Respiratory Distress Syndrome in Septic Patients

“…Acute Respiratory Distress Syndrome (ARDS) is a noncardiogenic pulmonary edema, in the basis of which lies an alteration (dystrophy, necrosis, apoptosis) of alveolar epithelium, pulmonary microcirculation endothelium, and their basal membranes (including structures of aerohematic barrier) by endogenous and exogenous aggressive factors, leading to a vascular permeability growth and development of acute respiratory failure [1][2][3].…”

“…Negovsky scientific research institute of general reanimatology. These criteria provided clinicians with a possibility to diagnose an early, reversible stage of ARDS, start prompt treatment, decrease the duration of artificial pulmonary ventilation by 4-7 days, the intensive care unit stay by 5-6 days, the hospital stay by 10 days, the rate of pulmonary complications by 31,9% and the mortality -by 29,6% [1][2][3][4].…”