Chronic Obstructive Pulmonary Disease 1995
DOI: 10.1007/978-1-4899-4525-9_19
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Acute Respiratory Failure

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Cited by 5 publications
(8 citation statements)
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References 169 publications
(139 reference statements)
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“…8 The most common cardiac arrhythmia seen in patients with respiratory failure due to COPD is sinus tachycardia, but premature atrial complexes, atrial fibrillation, premature ventricular complexes, and VT often are reported. 9,16 Factors reported to be potentially arrhythmogenic in these patients include the presence of cor pulmonale, hypoxemia, hypokalemia, increased levels of catecholamines, coexisting ischemic heart disease, and treatment with drugs such as digoxin, theophylline agents, and ␤-agonist agents. 9,17 Patients with hypoxemic COPD, in particular, have been reported to have subclinical autonomic neuropathy associated with prolonged QTc interval and associated risk of ventricular arrhythmias.…”
Section: Discussionmentioning
confidence: 99%
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“…8 The most common cardiac arrhythmia seen in patients with respiratory failure due to COPD is sinus tachycardia, but premature atrial complexes, atrial fibrillation, premature ventricular complexes, and VT often are reported. 9,16 Factors reported to be potentially arrhythmogenic in these patients include the presence of cor pulmonale, hypoxemia, hypokalemia, increased levels of catecholamines, coexisting ischemic heart disease, and treatment with drugs such as digoxin, theophylline agents, and ␤-agonist agents. 9,17 Patients with hypoxemic COPD, in particular, have been reported to have subclinical autonomic neuropathy associated with prolonged QTc interval and associated risk of ventricular arrhythmias.…”
Section: Discussionmentioning
confidence: 99%
“…9,16 Factors reported to be potentially arrhythmogenic in these patients include the presence of cor pulmonale, hypoxemia, hypokalemia, increased levels of catecholamines, coexisting ischemic heart disease, and treatment with drugs such as digoxin, theophylline agents, and ␤-agonist agents. 9,17 Patients with hypoxemic COPD, in particular, have been reported to have subclinical autonomic neuropathy associated with prolonged QTc interval and associated risk of ventricular arrhythmias. 10 The examination of some of these potential risk factors in patients with COPD and concurrent ischemic heart disease have revealed no significant increases in cardiac arrhythmias with the use of inhaled nebulized bronchodilators, 18 the use of oral theophylline in conjunction with albuterol, 19 or in the presence of hypokalemia induced by nebulized bronchodilator therapy.…”
Section: Discussionmentioning
confidence: 99%
“…17 The target Pao, is between 60 and 70 mm Hg, corresponding to the Pao, at which there is near-complete saturation of hemoglobin with 0,. Rarely, overzealous 0, administration produces progressive hypercapnia and respiratory acidosis.2o, 34, 74 For this reason, response to 0, must be assessed according to arterial blood gas and pH measurements. These should be obtained at baseline and within 60 minutes of starting or changing the 0, concentration.…”
Section: Controlled Oxygenmentioning
confidence: 99%
“…Theophylline has been used for decades to ameliorate symptoms in patients with airflow obstruction.lZ9 The use of theophylline in the management of stable COPD is discussed in the article by Ferguson in this issue. Theophylline has now been relegated to having a minor role in the acute setting because of the development of safer and more potent bronchodilators?l, 74 The lack of convincing, well-designed trials showing its efficacy has further contributed to the decline in its use.7o, 99,137 There are only two published studies that relate specifically to the role of theophylline in the treatment of COPD exacerbations. The first, by Rice et al,99 was a small, yet rigorously controlled trial in which patients were randomized to aminophylline infusion or placebo during hospitalization for AE-COPD.…”
Section: Theophyllinementioning
confidence: 99%
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