Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions

Sabeti, Zahra; Ansarin, Khalil; Seyedrezazadeh, Ensiyeh; Jafarabadi, Mohammad Asghari; Dastgiri, Saeed; Shakerkhatibi, Mohammad; Gholampour, Akbar; Khamnian, Zhila; Sepehri, Maryam; Dahim, M; Sharbafi, Jabraeil; Hakimi, Daryoush

doi:10.1016/j.envpol.2021.117797

Cited by 25 publications

(7 citation statements)

References 56 publications

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“…Long-term exposure to PM2.5 has a close association with respiratory diseases [ 1 , 2 ]. The mechanism of damage of PM2.5 to the respiratory system primarily includes inflammatory response [ 3 ], oxidative stress response [ 4 ], immunotoxicity [ 5 ] and genotoxicity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1

Xie

et al. 2022

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Objective: To explore the roles of macrophages’ miR-217-5p in the process of PM2.5 induced acute lung injury. Methods: GEO database and KEGG pathway enrichment analysis as well as GSEA were used to predicted the miRNA and associated target signals. And then mice and RAW246.7 macrophages treated with PM2.5 to imitate PM2.5 induced acute lung injury environment and then transfected with miR-217-5p NC or miR-217-5p mimic. The levels of inflammatory factors TNF-α and anti-inflammatory factor IL-10 of mice serum were tested by ELISA. And the pathological changes and ROS level of mouse lung tissues were stained by HE and DHE staining. The proteins expression of phosphorylated-STAT1, total-STAT1, TNF-α, IFN-γ as well as p47, gp91, NOX4 in mice or RAW264.7 cells were tested by western blot or immunofluorescence of RAW264.7 cell slides. Results: The results of bioinformatics analysis indicated the miR-217 as well as STAT1 were involved PM2.5 associated lung injury. After exposure to PM2.5, the decreased levels of serum TNF-α but not IL-10, consistent with reduced macrophages’ accumulation as well as decreased ROS levels in lung tissues in miR-217-5p mimic group vs miR-217-5p NC group mice, and moreover, the protein expression levels of phosphorylated--STAT1, total-STAT1, TNF-α, IFN-γ, p47, gp91 and NOX4 in mouse lung tissues and RTAW246.7 macrophages cells were all significantly reduced with miR-217-5p mimic administration. The above phenomena were reversed by specific STAT1-inhibitor HY-N8107. Conclusions: miR-217-5p suppressed the activated STAT1-signal induced inflammation and oxidative stress trigged by PM2.5 in macrophages and resulted in the decreased lung injure caused by PM2.5.

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Section: Introductionmentioning

confidence: 99%

MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1

Xie

et al. 2022

Aging

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“…Tsai et al (2014) reported that elevated levels of PM 2.5 were associated with chronic obstructive pulmonary disease (COPD), asthma and pneumonia. Exposure to PM 2.5 may trigger noticeable changes in airway oxidative stress (Sabeti et al, 2021). PM 4 is particulate matter of aerodynamic diameter of 4 µm.…”

Section: Discussionmentioning

confidence: 99%

Exhaled breath condensate markers of oxidative stress in male storekeepers of chemical stores in the Ariaria international market Aba Abia state Nigeria

2022

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In most developing countries, stores, where chemical substances are sold, are poorly ventilated, and best practices are not followed. This can result in the contamination of the ambient air inside the stores with toxicological implications for the lungs. This work aimed at determining the risk of pulmonary disease in chemical storekeepers in the Ariaria international market Aba by the evaluation of exhaled breath condensate (EBC) biomarkers of oxidative stress. A gas monitor was used for gas sampling while an Aerocet analyzer was used for particulate matter determinations. Exposed filter paper was used for the sampling of heavy metals in the air, and the determination was done using atomic absorption spectrophotometry. The exhaled breath condensate was collected with a refrigerated condenser, and the markers of oxidative stress were determined spectrophotometrically. Concentrations of particulate matter (PM1, PM2.5, PM4, PM7, PM10) were elevated in all the chemical stores studied. Our findings also showed that the indoor air of the chemical stores studied was polluted with SO2, NO2, NH3 and H2S, as their concentrations were respectively higher than the WHO standard values. Concentrations of all the heavy metals present in the ambient air of the chemical stores were also higher than the Nigerian Environmental Standard and Regulation Enforcement Agency (NESREA) standard values. Chemical storekeepers at the Ariaria international market exhaled increased concentrations of thiobarbituric acid reactive substances (TBARS), H2O2, and lower concentrations of glutathione (GSH). The pH values of the exhaled breath condensates were decreased and slightly acidic. It therefore means that the storekeepers were exposed to polluted ambient air inside the stores. This resulted to airway oxidative stress in the storekeepers as reported herein. Therefore, storekeepers of chemical stores in the Ariaria international market, Aba Nigeria were at risk of pulmonary disease(s).

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“…39 However, the electrochemical conversion strategy is more appealing, not only reducing the formation of acid rain, photochemical smog, and depletion of the ozone layer due to the presence of NO, but also avoiding the consumption of a reducing agent (NH 3 ) during the selective catalytic reduction process, which is one of the state-of-the-art and widely commercialized technologies for abating nitrogen oxides in the flue gases from coal-fuelled power plants, automobiles, and industrial facilities. 39,40 Therefore, coupling CO 2 with nitrogenous small molecules (NO, NO 2 À , NO 3 À , NH 3 , etc.) is a promising alternative path from the standpoint of ''turn waste into treasure'' for cost-effective electrosynthesis and environmental remediation, especially when driven by renewable energy.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical C–N coupling of CO₂and nitrogenous small molecules for the electrosynthesis of organonitrogen compounds

et al. 2023

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Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions

Cited by 25 publications

References 56 publications

MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1

MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1

Exhaled breath condensate markers of oxidative stress in male storekeepers of chemical stores in the Ariaria international market Aba Abia state Nigeria

Electrochemical C–N coupling of CO₂and nitrogenous small molecules for the electrosynthesis of organonitrogen compounds

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Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions

Cited by 25 publications

References 56 publications

MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1

MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1

Exhaled breath condensate markers of oxidative stress in male storekeepers of chemical stores in the Ariaria international market Aba Abia state Nigeria

Electrochemical C–N coupling of CO2and nitrogenous small molecules for the electrosynthesis of organonitrogen compounds

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Product

Resources

About

Electrochemical C–N coupling of CO₂and nitrogenous small molecules for the electrosynthesis of organonitrogen compounds