Acute results, complications, and effect of lesion characteristics on outcome with the solid‐state, pulsed‐wave, mid‐infrared laser angioplasty system: Final multicenter registry report

Abstract

Background and Objective:The solid-state, mid-infrared holmium:YAG laser (2.1 m wavelength) is a relatively new percutaneous device that has recently been evaluated in a multicenter study. Because of its unique wavelength and photoacoustic effects on atherosclerotic plaques, this laser may be useful in treatment of symptomatic patients with coronary artery disease. This study sought to evaluate the safety and efficacy of mid-infrared laser angioplasty in the treatment of coronary artery lesions. occurred in 2.2% of patients; major dissection in 5.8% of patients, and spasm in 12% of patients. No predictor of major complications was identified. Six-month angiographic restenosis was documented in 54% of patients, and clinical restenosis occurred in 34% of patients. Conclusion: Mid-infrared laser has a safety profile similar to that of other debulking devices. This laser may be useful in select patients presenting with acute ischemic syndromes associated with intracoronary thrombus; however, like other coronary lasers, it is limited by the need for adjunctive balloon angioplasty and/or stenting to achieve adequate final luminal diameter. No beneficial effects on reducing 6-month restenosis rates were observed. Patients and Methods

The Viability of Endovascular Laser Intervention for Peripheral Arterial Diseases

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] In the present study, based on our previous serial studies, the optimal conditions for endovascular laser intervention by Argon laser were an output power and exposure time of 6 W in output and 3 s, respectively, for the bare laser fiber, and a tip temperature and exposure time of 200°C and 5 sec, respectively, for the heated tip. 2,16) On the other hand, several other sets of laser parameters (6-12 W output, 3-10 s irradiation time) have been reported depending on to the kind of laser system and laser fibers used.…”

Excimer Laser Coronary Angioplasty in Acute Myocardial Infarction

“…The presence of thrombus in the lesion has been reported to increase the success of angioplasty treatment using holmium laser, 18 while an earlier study using excimer laser found that it increased distal embolization and non-Q wave MI related to the procedure. 19 Topaz and associates, 4 applying ELCA in 50 patients with acute MI, obtained a success rate of laser ablation of 98% and of the procedure of 100%.…”

Vascular procedures that thermo‐coagulate collagen reduce local platelet deposition and thrombus formation: Laser and laser‐thermal versus balloon angioplasty

“…temperatures required for peripheral artery recanalization in patients using LTA were found to range between 74-4508C at the probe tip. Thus, a wide range in temperatures generated by lasing and various devices may explain the great differences in the incidence of restenosis observed in clinical studies [21,22]. In fact, Spears et al [23] using laser balloon angioplasty demonstrated that different energy levels altered the restenosis rate in human coronary arteries.…”