Acute Reversible Cardiomyopathy and Thromboembolism After Cisplatin and 5-Fluorouracil Chemotherapy

Cheriparambil, Kuruvilla; Vasireddy, Hemalatha; Kuruvilla, Anita; Gambarin, Boris; Makan, Majesh; Saul, Barry I.

doi:10.1177/000331970005101011

Cited by 19 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CoumarinsAnti-inflammatory [47], antioxidant [48], anti-cancer [49]. TerpenoidsAntiinflammatory [5, 6], chemopreventive, anticancer [10] renoprotective against CP [11]. QuantitativeEstimation Flavonoids : 129 ± 1.32 TFC (mg rutin equivalent/g dry sample)[25]Antioxidant, anticancer, induced apoptosis, inhibit oxidative stress, flavonids exibit protection against CP induced nephrotoxicity [36], i.e.…”

Section: Methodsmentioning

confidence: 99%

“…Cisplatin usage is also associated with the cardiotoxicity including arrhythmia, myocarditis, cardiomyopathy and congestive heart failure [1–5]. CP treatment in combination with complementary anticancer medications such as methotrexate, 5-fluorouracil, bleomycin and doxorubicin is concomitant with fatal cardiac disorders [6]. CP-containing chemotherapy to the patients encourages deterioration in the abundance of various antioxidants in the plasma, which may lead to the failure of anti-oxidative defense mechanism.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats

Afsar

Razak

Almajwal

et al. 2019

BMC Complement Altern Med

View full text Add to dashboard Cite

Background Increase oxidative trauma is the main cause behind Cisplatin (CP) induced cardiotoxicity which restricts its clinical application as anti-neoplastic prescription. Acacia hydaspica is a natural shrub with diverse bioactivities. Acacia hydaspica ethyl acetate extract (AHE) ameliorated drug-induced cardiotoxicity in animals with anti-oxidative mechanisms. Current study aimed to evaluate the protective potential of A. hydaspica against cisplatin-induced myocardial injury. Methods Rats were indiscriminately distributed into six groups (n = 6). Group 1: control; Groups 2: Injected with CP (7.5 mg/kg bw, i.p, single dose) on day 16; Group 3: Treated for 21 days with AHE (400 mg/kg b.w, oral); Group 4: Received CP injection on day 16 and treated with AHE for 5 days post injection; Group 5: Received AHE (400 mg/kg b.w/day, p.o.) for 21 days and CP (7.5 mg/kg b.w., i.p.) on day 16; Group 6: Treated with silymarin (100 mg/kg b.w., p.o.) after 1 day interval for 21 days and CP injection (7.5 mg/kg b.w., i.p.) on day 16. On 22nd day, the animals were sacrificed and their heart tissues were removed. Cisplatin induced cardiac toxicity and the influence of AHE were evaluated by examination of serum cardiac function markers, cardiac tissue antioxidant enzymes, oxidative stress markers and histology. Results CP inoculation considerably altered cardiac function biomarkers in serum and diminished the antioxidant enzymes levels, while increased oxidative stress biomarkers in cardiac tissues AHE treatment attenuated CP-induced deteriorations in creatine kinase (CK), Creatine kinase isoenzymes MB (CK-MB), cardiac Troponin I (cTNI) and lactate dehydrogenase (LDH) levels and ameliorated cardiac oxidative stress markers as evidenced by decreasing lipid peroxidation, H2O2 and NO content along with augmentation in phase I and phase II antioxidant enzymes. Additionally, CP inoculation also induced morphological alterations which were ameliorated by AHE. In pretreatment group more significant protection was observed compared to post-treatment group indicating preventive potential of AHE. The protective potency of AHE was comparable to silymarin. Conclusion Results demonstrate that AHE attenuated CP induce cardiotoxicity. The polyphenolic metabolites and antioxidant properties of AHE might be responsible for its protective influence.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats

Afsar

Razak

Almajwal

et al. 2019

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…To date, 10 case vignettes have been published reporting TCM related to 5-FU administration [23,26,[42][43][44]. The patients represented in the case reports range from 14 to 79 years of age [45,46].…”

Section: Takotsubo Cardiomyopathy and Cancermentioning

confidence: 99%

“…Most of these patients presented with chest pain. One presented with ventricular fibrillation cardiac arrest (who subsequently survived), and one experienced sudden circulatory collapse and death during the fifth cycle of 5-FU infusion following recovery from TCM during the first cycle [42,43]. These 10 patients had varying degrees of ECG changes and had reduced LVEF ranging from 10 to 34%.…”

Section: Takotsubo Cardiomyopathy and Cancermentioning

confidence: 99%

Takotsubo cardiomyopathy in cancer patients

et al. 2019

View full text Add to dashboard Cite

Background: Cancer is a chronic condition that induces significant emotional and physical stress, which may increase the risk for developing Takotsubo cardiomyopathy (TCM). Main body: Takotsubo cardiomyopathy, also known as stress cardiomyopathy, is a clinical syndrome that generally presents as chest pain mimicking acute coronary syndrome or as an acute heart failure characterized by severe left ventricular systolic dysfunction in response to emotional, physical, or medical stress. The potential triggers for Takotsubo syndrome in cancer patients include the emotional turmoil of a cancer diagnosis, the inflammatory state of the cancer itself, and the physical stress of cancer surgery, systemic anti-neoplastic therapy, and radiation treatment. TCM is becoming increasingly recognized among patients with cancer and has been associated with adverse outcomes in this patient population. In this study, we searched the Pubmed database using keywords "Takotsubo cardiomyopathy", "cancer", and "anti-neoplastic therapy" to review case reports of Takotsubo syndrome occurring in oncologic patients after systemic anti-neoplastic therapy. Clinical presentation, electrocardiogram, laboratory data, transthoracic echocardiogram and coronary angiogram results, and patient outcomes were collected and analyzed. Conclusion: Patients with cancer are at an elevated risk for developing stress cardiomyopathy, and it is important to know which cancer drugs have been associated with the development of the Takotsubo syndrome.

show abstract

“…Reports of intracardiac thrombus following cisplatin-based regimens and 5-FU, although rare, can be found in the literature [13] [14] [15], but very little is available on the safety of the continuation of treatment in these cases, as many patients don't survive or are not fit enough for therapy afterwards. On the case reported by Ikeda et al, the patient resumed therapy after resolution on the thrombus, which was not possible in our patient [16].…”

Section: Discussionmentioning

confidence: 99%

Could a Cutaneous Lesion Mean Gastric Cancer? Case Report of a Rare Diagnostic Tool and the Management of a Cardiac Complication during Chemotherapy

Gaspar¹,

Leitão²,

Machado³

2020

JCT

View full text Add to dashboard Cite

Cutaneous presentation of gastric cancer is very rare. This case report is about a patient with a metastatic gastric cancer in which the diagnosis was made by a cutaneous biopsy. Following this unusual diagnostic tool, the patient had an intracardiac thrombus, during the chemotherapy regimen, which wasn't a contraindication for pursuing chemotherapy treatment for over 12 months. This case report is presented to make clinicians aware of a possible atypical sign of presentation of gastrointestinal tract cancer, as well as the importance of clinical suspicion of a well-known problem affecting cancer patients such as venous thromboembolism and its repercussions in the treatment options.

show abstract

Acute Reversible Cardiomyopathy and Thromboembolism After Cisplatin and 5-Fluorouracil Chemotherapy

Cited by 19 publications

References 22 publications

Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats

Evaluating the protective potency of Acacia hydaspica R. Parker on histological and biochemical changes induced by Cisplatin in the cardiac tissue of rats

Takotsubo cardiomyopathy in cancer patients

Could a Cutaneous Lesion Mean Gastric Cancer? Case Report of a Rare Diagnostic Tool and the Management of a Cardiac Complication during Chemotherapy

Contact Info

Product

Resources

About