Acute Rheumatic Fever and Kawasaki Disease Occurring in a Single Patient

Iio, Kazuki; Fukushima, Naoya; Akamine, Keiji; Uda, Kazuhiro; Hataya, Hiroshi; Miura, Masaru

doi:10.3389/fped.2020.00562

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…IVIg treatment reduces the occurrence of CAL in KD to a mere 5% when administered promptly [7]. As a result of these long-term cardiac sequelae which cannot be fully mitigated, KD is one of the leading cause of acquired heart disease in children globally [8].…”

Section: Kawasaki Diseasementioning

confidence: 99%

The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key

Markandran,

Clemente,

Tan

et al. 2024

Preprint

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Kawasaki disease is a febrile illness characterised by systemic inflammation of small- and medium-sized blood vessels which commonly occurs in young children. Although self-limiting, there is a risk of developing coronary artery lesions as disease progresses with delay in diagnosis and treatment. Unfortunately, the diagnosis of KD continues to remain a clinical dilemma. Thus, this article not only summarises the key research gaps associated to KD, but also evaluates the possibility of using circulating endothelial injury biomarkers such as, circulating endothelial cells, endothelial microparticles and vascular endothelial cell-free DNA, as diagnostic and prognostic tool of KD: a “liquid biopsy” approach. The challenges of translating liquid biopsies to use in KD, and the opportunities for improvement in its diagnosis and management that such translation may provide are discussed. The use of endothelial damage markers, which are easily obtained via blood collection, as diagnostics is promising and we hope this will be translated to clinical applications in the near future.

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Section: Kawasaki Diseasementioning

confidence: 99%

The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key

Markandran,

Clemente,

Tan

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key

Markandran,

Clemente,

Tan

et al. 2024

IJMS

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Kawasaki disease (KD) is a febrile illness characterised by systemic inflammation of small- and medium-sized blood vessels, which commonly occurs in young children. Although self-limiting, there is a risk of developing coronary artery lesions as the disease progresses, with delay in diagnosis and treatment. Unfortunately, the diagnosis of KD continues to remain a clinical dilemma. Thus, this article not only summarises the key research gaps associated with KD, but also evaluates the possibility of using circulating endothelial injury biomarkers, such as circulating endothelial cells, endothelial microparticles and vascular endothelial cell-free DNA, as diagnostic and prognostic tools for KD: a “liquid biopsy” approach. The challenges of translating liquid biopsies to use in KD and the opportunities for improvement in its diagnosis and management that such translation may provide are discussed. The use of endothelial damage markers, which are easily obtained via blood collection, as diagnostic tools is promising, and we hope this will be translated to clinical applications in the near future.

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A Systematic Review of Atypical Presentations of Kawasaki Disease

Arjmand,

Soltani,

Yousefi Manesh

et al. 2023

Int J Enteric Pathog

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Background: Kawasaki disease (KD) is a systematic vasculitis that mainly affects children under five years old. Diagnosis is made based on clinical criteria. Objectives: This study aimed to determine various atypical presentations of KD to prevent misdiagnosis. Methods: A comprehensive systematic search in PubMed, Web of Science, and Scopus databases was performed based on the PRISMA guidelines from 2012 to January 2023. Case reports and case series studies reporting the atypical presentations of KD, only in the English language, were included, and the Joanna Briggs Institute (JBI) checklist was utilized for case report studies as a quality assessment tool. Results: Our findings revealed that patients with KD can present with gastrointestinal and hepatobiliary, cardiovascular, mucocutaneous, neurological, musculoskeletal, respiratory, retropharyngeal, and renal complications. Macrophage activation syndrome and normal inflammatory biomarkers were rare manifestations. The most common cause of the patient’s death was cardiovascular manifestations, especially myocardial infarction. Cardiovascular and gastrointestinal involvement were the most prevalent. Conclusion: Focusing on atypical and rare manifestations facilitates the correct diagnosis, leading to timely and appropriate management, improving outcomes, and reducing complications.

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Acute Rheumatic Fever and Kawasaki Disease Occurring in a Single Patient

Cited by 3 publications

References 17 publications

The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key

The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key

The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key

A Systematic Review of Atypical Presentations of Kawasaki Disease

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