Acute salicylate poisoning: risk factors for severe outcome

Shively, Rachel M.; Hoffman, Robert S.; Manini, Alex F.

doi:10.1080/15563650.2016.1271127

Cited by 20 publications

(9 citation statements)

References 24 publications

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“…Recently, an association was found between the initial ED lactate concentration and severe outcome in patients with acute salicylate poisoning. 21 The data from the present study demonstrate prognostic utility for fatality following salicylate overdose with an optimal cutpoint of 6.0 mmol/L. This may be representative of the toxicity exerted by uncoupled oxidative phosphorylation as well as increased work of breathing.…”

Section: Discussionmentioning

confidence: 57%

Prognostic Utility of Initial Lactate in Patients With Acute Drug Overdose: A Validation Cohort

Cheung¹,

Hoffman²,

Vlahov³

et al. 2018

Annals of Emergency Medicine

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Section: Discussionmentioning

confidence: 57%

Prognostic Utility of Initial Lactate in Patients With Acute Drug Overdose: A Validation Cohort

Cheung¹,

Hoffman²,

Vlahov³

et al. 2018

Annals of Emergency Medicine

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“…This discrepancy is, again, likely due to the inclusion of patients from the outpatient setting in their report, which tend to have less severe salicylate intoxications. Other previous studies have reported mortality rates of salicylate intoxication ranging from 4 to 10% [ 11 , 12 , 13 , 14 ]. Our study further identified independent factors associated with increased in-hospital mortality in hospitalized patients with salicylate intoxication.…”

Section: Discussionmentioning

confidence: 99%

“…As such, it has been recommended that bicarbonate therapy can be given prior to intubation in an effort to maintain the serum pH [ 3 ]. Finally, other studies have similarly identified risk factors for increased mortality, including age, neurological symptoms, serum salicylate levels, delayed diagnosis, respiratory rate, and acidosis [ 11 , 12 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Hospitalizations for Acute Salicylate Intoxication in the United States

Petnak

Kaewput

Mao

et al. 2020

JCM

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Background: The objective of this study was to describe inpatient prevalence, characteristics, outcomes, and resource use for acute salicylate intoxication hospitalizations in the United States. Methods: A total of 13,805 admissions with a primary diagnosis of salicylate intoxication from 2003 to 2014 in the National Inpatient Sample database were analyzed. Prognostic factors for in-hospital mortality were determined using multivariable logistic regression. Results: The overall inpatient prevalence of salicylate intoxication among hospitalized patients was 147.8 cases per 1,000,000 admissions in the United States. The average age was 34 ± 19 years. Of these, 35.0% were male and 65.4% used salicylate for suicidal attempts. Overall, 6% required renal replacement therapy. The most common complications of salicylate intoxication were electrolyte and acid-base disorders, including hypokalemia (25.4%), acidosis (19.1%), and alkalosis (11.1%). Kidney failure (9.3%) was the most common observed organ dysfunction. In-hospital mortality was 1.0%. Increased in-hospital mortality was associated with age ≥30, Asian/Pacific Islander race, diabetes mellitus, hyponatremia, ventricular arrhythmia, kidney failure, respiratory failure, and neurological failure, while decreased in-hospital mortality was associated with African American and Hispanic race. Conclusion: hospitalization for salicylate intoxication occurred in 148 per 1,000,000 admissions in the United States. Several factors were associated with in-hospital mortality.

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“…The purpose of mechanical ventilation is not always to achieve the normal blood gas concentration. Given the predisposition to hypoventilation and the risk of acute pulmonary edema, the mechanical ventilation of patients intoxicated with salicylates requires a lot of attention [18,19]. Highfrequency ventilation and ECMO should be considered to treat some severe intoxications, but there are limited reports on their use in pediatric toxicology [4,20].…”

Section: The Poisoning Effects On Specific Organ Systems 41 Acute Rementioning

confidence: 99%

Poisoning in the Pediatric Intensive Care Unit

Nistor¹,

Frăsinariu²,

Rugină³

et al. 2019

Poisoning in the Modern World - New Tricks for an Old Dog?

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Poisonings during childhood (both accidental and voluntary) are a common cause of presentation in the emergency departments (EDs) and the pediatric intensive care unit (PICU). The admission to PICU is warranted both for treatment and for continuous monitoring, as sometimes the evolution of a poisoning could be unpredictable. Sometimes, complications arise that may prolong the patients' hospitalization and may contribute to lowering the survival rate. The staff in these departments must be well trained to ensure patient monitoring, early detection of complications, and rapid intervention. Supporting vital functions is the main objective of the management of a poisoned patient admitted in PICU. In recent years, staff competence and advanced medical technology have helped to improve the prognosis of the patients admitted to these departments, including of the poisoned patients.

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Acute salicylate poisoning: risk factors for severe outcome

Cited by 20 publications

References 24 publications

Prognostic Utility of Initial Lactate in Patients With Acute Drug Overdose: A Validation Cohort

Prognostic Utility of Initial Lactate in Patients With Acute Drug Overdose: A Validation Cohort

Hospitalizations for Acute Salicylate Intoxication in the United States

Poisoning in the Pediatric Intensive Care Unit

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