Acute sarcoid myopathy and neuropathy aggravated by ustekinumab administration in an elderly woman with psoriasis and systemic sarcoidosis

Sano, Hironori; Maeda, Toshihiko; Sato, Ryota; Shimizu, Fumitaka; Koga, Michiaki; Kanda, Takashi

doi:10.5692/clinicalneurol.cn-001714

Rinsho Shinkeigaku

2022

DOI: 10.5692/clinicalneurol.cn-001714

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Acute sarcoid myopathy and neuropathy aggravated by ustekinumab administration in an elderly woman with psoriasis and systemic sarcoidosis

Hironori Sano

Toshihiko Maeda

Ryota Sato

et al.

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Cited by 3 publications

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Paradoxical granulomatous reaction to ustekinumab

Obijiofor,

Mazori,

Femia

et al. 2024

JEADV Clinical Practice

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Sarcoidosis is a multisystem disorder characterised by granulomatous inflammation affecting various organs. The skin is commonly involved and can serve as an initial indicator of disease. While the precise aetiology of sarcoidosis remains elusive, evidence suggests involvement of T‐helper type (TH)‐1 and TH‐17 pathways. Psoriasis shares common inflammatory pathways with sarcoidosis, prompting the repurposing of biologic therapies approved for psoriasis for off‐label treatment of cutaneous sarcoidosis. However, this approach has raised concerns due to the development of granulomatous eruptions in some patients. We present a case of a patient with psoriasis who was diagnosed with systemic sarcoidosis while on ustekinumab. We review previous cases of ustekinumab‐associated sarcoidosis and discuss the challenges associated with utilising biologic agents originally intended for psoriasis treatment for sarcoidosis.

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Paradoxical granulomatous reaction to ustekinumab

Obijiofor,

Mazori,

Femia

et al. 2024

JEADV Clinical Practice

View full text Add to dashboard Cite

show abstract

Ustekinumab

2022

Reactions Weekly

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Efficacy and safety of biologics and small molecules for psoriasis in pediatric and geriatric populations. Part II: focus on elderly patients

Megna

Camela

Battista

et al. 2023

Expert Opinion on Drug Safety

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Acute sarcoid myopathy and neuropathy aggravated by ustekinumab administration in an elderly woman with psoriasis and systemic sarcoidosis

Cited by 3 publications

References 20 publications

Paradoxical granulomatous reaction to ustekinumab

Paradoxical granulomatous reaction to ustekinumab

Ustekinumab

Efficacy and safety of biologics and small molecules for psoriasis in pediatric and geriatric populations. Part II: focus on elderly patients

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