Acute Sensory Neuropathy and Progressive Dysphagia with Anti-GQ1b Antibody Positive: A Case Report

Abstract

Anti-GQ1b ganglioside antibody is associated with ophthalmoplegia, ataxia, and areflexia, resulting in the development of Miller Fisher Syndrome (MFS), Guillain-Barré Syndrome (GBS) with ophthalmoplegia and Bickerstaff brainstem encephalitis. We presented the case of a 43-yearold male with numbness of all extremities, progressive dysphagia and dysarthria. He had a history of flu-like symptoms before his numbness. Physical examination found decreased in pinprick sensation, limb ataxia, hyporeflexia and decreased response of gag reflex. The results of the MRI brain and cervical spine were found normal. The biochemical examination of cerebrospinal fluid was found normal. He was treated with Intravenous Immunoglobulin (IVIG) for five days. He has recovered completely and could return to work within four weeks. The result of his serum anti-GQ1b antibody was reported positive. Although clinical symptoms do not match the criteria diagnosis of MFS or GBS, however the evaluation of specific antibodies help in the diagnostics and thus early effective treatment is possible.