Acute Severe Cushing Syndrome: Not Always Ectopic Acth Syndrome

Bello, Carlos Tavares; Gil, Inês; Serra, Filipa; Duarte, João Sequeira

doi:10.4158/ep171905.cr

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2021

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“…4 Acute severe symptoms of hypercortisolism are uncommon in CD and are typically noted in ectopic ACTH syndromes. 5 Our patient had an acute, severe, and rapidly progressing clinical presentation with multiple metabolic consequences in the absence of a typical clinical phenotype.…”

Section: Discussionmentioning

confidence: 82%

Acute severe Cushing’s disease presenting as a hypercoagulable state

Fariduddin

Syed

Divan

et al. 2021

Baylor University Medical Center Proceedings

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Cushing's disease (CD) is the most common cause of endogenous cortisol excess. We discuss the case of a 60-year-old woman with recurrent venous thromboembolism, refractory hypokalemia, and lumbar vertebrae compression fractures with a rapidly progressive disease course. Ectopic hypercortisolism was suspected given the patient's age and rapid onset of disease. Investigations revealed cortisol excess from a pituitary microadenoma. This case demonstrates that CD can present with severe findings and highlights the increased risk of venous thromboembolism in hypercortisolism, especially in CD.

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Section: Discussionmentioning

confidence: 82%