Acute Sinusitis  in Outpatient Clinical Practice: Current Guidelines  for the Diagnosis  and  Treatment  Of

Дербенева, М. Л.

doi:10.21518/2079-701x-2017-8-13-17

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be emphasized that oral forms of naphazoline incur the major risk of systemic intoxication, and they are prohibited for use in pediatric practice in Russia until the age of 12. (Derbeneva and Guseva 2017;Radzig 2017;Bogomilsky et al 2019).…”

Section: Main Causes Of Acute Poisoning In Young Childrenmentioning

confidence: 99%

Pathogenetic features of acute naphazoline poisoning in children

Karpushkina¹,

Zhdanova²,

Батищева³

et al. 2021

RRP

View full text Add to dashboard Cite

Introduction: Acute poisoning by nasal decongestants is an important issue in pediatrics due to physiological and anatomical characteristics of the child’s body and pharmacokinetics of drugs in early childhood. Epidemiology: The number of poisonings by this group of drugs ranged from 4% to 39% during the period from 2000 to 2018. All the studies reported that the most severe degree of intoxication was observed in children aged 1–3 years. Mechanism of action of nasal decongestants: The peculiarity of selective alpha2-adrenergic agonists is that when taken orally, misused or overdosed, they lose their selectivity for the target receptor. As a result, the drug causes acute poisoning and most often this effect occurs in children and adolescents. Clinical features and diagnostic criteria: Clinical signs of acute poisoning can appear both as a result of an overdose of the nasal decongestants and due to a therapeutic use of the drug according to the instruction. The symptoms are manifested by hypothermia, skin pallor, bradycardia, arterial hypotension, profuse sweating, and acrocyanosis. Imidazoline receptors and new opportunities: It is assumed that toxic effect of topical decongestants occurs not only by activation of alpha2-adrenergic receptors, but also through their influence on the selective imidazoline receptors. Based on the structure of these drugs, it is assumed that imidazoline receptors are the primary binding site for these drugs. Conclusion: Understanding the described mechanisms of alpha2-adrenergic agonist action and peculiarities of the child’s symptoms in acute poisoning is necessary for the timely diagnosis and selection of the correct treatment strategy.

show abstract

Section: Main Causes Of Acute Poisoning In Young Childrenmentioning

confidence: 99%

Pathogenetic features of acute naphazoline poisoning in children

Karpushkina¹,

Zhdanova²,

Батищева³

et al. 2021

RRP

View full text Add to dashboard Cite

show abstract

Проблема Антибиотикорезистентности У Пациентов С Острым И Хроническим Риносинуситом

Еременко,

Сиделова,

Шестакова

et al. 2020

Оториноларингология. Восточная Европа

View full text Add to dashboard Cite

Характер и течение воспалительного процесса при бактериальной инфекции во многом определяются видом возбудителя и его патогенными свойствами. Динамично меняющийся спектр микроорганизмов и формирование биопленок является одним из факторов роста резистентности к антибиотикам.В статье представлена резистентность к антибактериальным лекарственным средствам пленкообразующих изолятов бактерий, выделенных от пациентов с острым и хроническим риносинуситом.Установлено, что 30% всех исследованных изолятов, выделенных от пациентов с острым риносинуситом, обладали сильной способностью к биопленкообразованию, 40% – умеренной, 18% – слабой и 12% – не обладали способностью к биопленкообразованию. Среди исследованных изолятов бактерий самым распространенным оказался S. aureus. Высокий уровень резистентности пленок Staphylococcus aureus, выделенных от пациентов с острым риносинуситом, отмечен к аминопенициллинам, цефалоспоринам 3-го поколения, карбапенемам и левофлоксацину.У пациентов с хроническим риносинуситом 67% всех исследованных изолятов обладали сильной способностью к биопленкообразованию, 17% – умеренной, 9% – слабой и 7% – не обладали способностью к биопленкообразованию. Среди исследованных изолятов бактерий самым распространенным оказался S. aureus. Высокий уровень резистентности пленок S. aureus, выделенных от пациентов с хроническим риносинуситом, отмечен практически ко всем исследуемым антибактериальным лекарственным средствам.Полученные данные диктуют необходимость накапливать знания по биопленочным инфекциям и резистентности различных штаммов микроорганизмов, а также рационально подходить к вопросу назначения антибактериальных лекарственных средств. The nature and course of the inflammatory process with bacterial infection is largely determined by the type of pathogen and its pathogenic properties. The dynamically changing spectrum of microorganisms and the formation of biofilms is one of the factors for the growth of antibiotic resistance.The article presents resistance to antibacterial drugs of film-forming bacterial isolates isolated from patients with acute and chronic rhinosinusitis.It was found that 30% of all the studied isolates isolated from patients with acute rhinosinusitis had a strong ability to biofilm formation, 40% – moderate, 18% – weak and 12% – did not have the ability to biofilm. Among the studied bacterial isolates, S.aureus was the most common. A high level of resistance of S. aureus films isolated from patients with acute rhinosinusitis was noted for aminopenicillins, 3rd generation cephalosporins, carbapenems, and levofloxacin.In patients with chronic rhinosinusitis, 67% of all the studied isolates had a strong ability to biofilm formation, 17% – moderate, 9% – weak and 7% – did not have the ability to biofilm. Among the studied bacterial isolates, S. aureus was the most common. A high level of resistance of S.aureus films isolated from patients with chronic rhinosinusitis is noted for almost all studied antibacterial drugs. The data obtained dictate the need to accumulate knowledge on biofilm infections and the resistance of various strains of microorganisms, as well as rationally approach the issue of prescribing antibacterial drugs.

show abstract

Acute Sinusitis in Outpatient Clinical Practice: Current Guidelines for the Diagnosis and Treatment Of

Cited by 2 publications

References 23 publications

Pathogenetic features of acute naphazoline poisoning in children

Pathogenetic features of acute naphazoline poisoning in children

Проблема Антибиотикорезистентности У Пациентов С Острым И Хроническим Риносинуситом

Contact Info

Product

Resources

About