Acute Sleep Deprivation Is Associated with Increased Atrial Electromechanical Delay in Healthy Young Adults

Esen, Özlem; Akçakoyun, Mustafa; Açar, Göksel; Bulut, Mehmet; Alızade, Elnur; Kargın, Ramazan; Emiroğlu, Mehmet Yunus; Yazıcıoğlu, Mehmet Vefik; Gemici, Kani; Esen, Ali Metin

doi:10.1111/j.1540-8159.2011.03186.x

Cited by 24 publications

(10 citation statements)

References 35 publications

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“…Previous studies demonstrated sleep deprivation could be an important AF predictor as assessed by electrocardiogram parameters 32, 33 . The Physicians’ Health Study 30 also found short, but not long, sleep duration was associated with a higher risk of AF in people with sleep apnoea.…”

Section: Discussionmentioning

confidence: 99%

Long Sleep Duration Is an Independent Risk Factor for Incident Atrial Fibrillation in a Chinese Population: A Prospective Cohort Study

Song

Liu

et al. 2017

Sci Rep

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There is limited information on the relation between sleep duration and incident atrial fibrillation. We aimed to investigate this association in a Chinese population using cohort data from a study in Kailuan. The analysis included 87,693 participants (age range, 18–98 years) free of atrial fibrillation at the baseline survey. Participants were divided into three categories according to self-reported sleep duration: ≤6.0 hours, 7 hours (ref), ≥8.0 hours. Atrial fibrillation diagnosis was made on a standard 12-lead electrocardiogram and via self-reported history. Cox proportional hazards models were used to calculate hazard ratio (HR) and confidence interval (CI) for atrial fibrillation, according to sleep duration. During median follow-up of 7.89 (range, 6.36–8.57) years, 322 cases of atrial fibrillation had occurred. Using 7 hours of sleep as the reference group, multivariable adjusted HRs (95% CI) for atrial fibrillation were 1.07 (0.75–1.53), 1.0 (ref), and 1.50 (1.07–2.10), from lowest to highest category of sleep duration. Secondary analysis showed no evidence of interactions between sleep duration and sex and snoring on the risk of incident atrial fibrillation (p = 0.75/0.25). We conclude long sleep duration may be a potential predictor/marker for incident atrial fibrillation.

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Section: Discussionmentioning

confidence: 99%

Long Sleep Duration Is an Independent Risk Factor for Incident Atrial Fibrillation in a Chinese Population: A Prospective Cohort Study

Song

Liu

et al. 2017

Sci Rep

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“…The biological evidence supporting a possible pathway between insomnia and AF was partly deduced from experimental studies concerning controlled sleep deprivation. Recent studies showed that acute SD is associated with increased P‐wave dispersion and QT dispersion and higher values of inter‐intra‐atrial electromechanical delay that are known to be associated with AF development and/or recurrence . Acute sleep deprivation in healthy adults was associated with a reduction in left atrial early diastolic strain rate without geometric alterations or functional impairment of the left atrium, suggesting that chronic sleep deprivation may play a more profound role in left atrium function and thereby accelerate the occurrence of AF .…”

Section: Discussionmentioning

confidence: 99%

Association between insomnia and atrial fibrillation in a Chinese population: A cross‐sectional study

Han

Yang

Chen

et al. 2017

Clinical Cardiology

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Background Insomnia is the most prevalent sleep disorder; however, little research has explored the link between insomnia and atrial fibrillation (AF). Hypothesis Insomnia is associated with increased risk of AF in a Chinese population. Methods A total of 8371 Chinese participants (4314 males; mean age, 42.4 ± 13.1 years) were enrolled in this cross‐sectional study to investigate the association between insomnia and AF. AF was assessed in a standard supine resting position with a 10‐s 12‐lead electrocardiograph (ECG) or by self‐reported history. Insomnia was assessed using the Athens Insomnia Scale (AIS), and a score of ≥6 was regarded as having insomnia. The association between insomnia and AF was determined by logistic regression analysis. Results Among the 8371 subjects, 1074 (12.8%) had different degrees of insomnia, and AF was observed in 50 subjects (0.60%). After adjusting for potential confounders, individuals with insomnia had moderately increased likelihood of suffering from AF compared with those without insomnia (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.00‐3.70, P = 0.05). After stratifying data by age, a significant positive association was found in those age <40 years (OR: 6.52, 95% CI: 1.64‐25.83, P = 0.01), and a similar trend existed in males after stratifying by sex, although this relationship was not statistically significant (OR: 2.11, 95% CI: 0.92‐4.83, P = 0.08). Conclusions Individuals with insomnia may have a higher risk of AF in the particular Chinese population assessed in this study. Age (<40 years) is a significant factor in the association between insomnia and AF.

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“…Sari et al 29 demonstrated that sleep deprivation was associated with prolonged maximum P-wave duration and P-wave dispersion, 2 conditions known to represent inhomogeneous conduction of sinus impulses and thereby electrophysiologic predictors of AF. Esen et al 30 demonstrated that even one night of sleep deprivation is associated with a higher risk of atrial electromechanical delay (AEMD) in healthy young adults. AEMD, calculated from tissue doppler imaging has been shown to detect atrial impairment in paroxysmal AF.…”

Section: Discussionmentioning

confidence: 99%

Sleep Duration and Risk of Atrial Fibrillation (from the Physicians' Health Study)

Khawaja

Sarwar

Chen

et al. 2013

The American Journal of Cardiology

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While sleep quality and duration have been related to cardiovascular endpoints, little is known about the association between sleep duration and incident atrial fibrillation (AF). Hence, we prospectively examined the association between sleep duration and incident AF in a cohort of 18,755 US male physicians. Self-reported sleep duration was ascertained during 2002 annual follow-up questionnaire. Incident AF was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of AF. The average age at baseline was 67.7 (+8.6) years. During a mean follow up of 6.9 (±2.1) years, 1,468 cases of AF occurred. Using 7 hours of sleep as the reference group, multivariable adjusted hazard ratios (95% CI) for AF were 1.06 (0.92–1.22), 1.0 (ref), and 1.13 (1.00–1.27) from the lowest to the highest category of sleep duration (p for trend 0.26), respectively. In a secondary analysis, there was no evidence of effect modification by adiposity (p interaction =0.69); however, prevalent sleep apnea modified the relation of sleep duration with AF (p interaction =0.01): from the highest to the lowest category of sleep duration, multivariable adjusted hazard ratios (95% CI) for AF were 2.26 (1.26–4.05), 1.0 (ref), and 1.34 (0.73–2.46) for those with prevalent sleep apnea and 1.01 (0.87–1.16), 1.0 (ref), and 1.12 (0.99–1.27) for those without sleep apnea, respectively. Our data showed a modestly elevated risk of AF with long sleep duration among US male physicians. Furthermore, shorter sleep duration was associated with a higher risk of AF in people with prevalent sleep apnea.

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Acute Sleep Deprivation Is Associated with Increased Atrial Electromechanical Delay in Healthy Young Adults

Abstract: In conclusion, in this cross-sectional study, we clearly found that even one night of SD is associated with higher values of inter-AEMD and intra-AEMD in healthy young adults.

Cited by 24 publications

References 35 publications

Long Sleep Duration Is an Independent Risk Factor for Incident Atrial Fibrillation in a Chinese Population: A Prospective Cohort Study

Long Sleep Duration Is an Independent Risk Factor for Incident Atrial Fibrillation in a Chinese Population: A Prospective Cohort Study

Association between insomnia and atrial fibrillation in a Chinese population: A cross‐sectional study

Sleep Duration and Risk of Atrial Fibrillation (from the Physicians' Health Study)

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