Acute Sleep Restriction Reduces Insulin Sensitivity in Adolescent Boys

Klingenberg, Lars; Chaput, Jean‐Philippe; Holmbäck, Ulf; Visby, Trine; Jennum, Poul; Nikolic, Miki; Astrup, Arne; Sjödin, Anders

doi:10.5665/sleep.2816

Cited by 103 publications

(90 citation statements)

References 27 publications

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“…Several potential biologic mechanisms may contribute to the relation of short sleep duration and diabetes. First, laboratory studies have corroborated and extended the decreases in glucose tolerance and insulin sensitivity after sleep restriction, as shown by increased hepatic glucose production and reduced peripheral glucose disposal (33)(34)(35)(36)(37). A recent research indicated that slow wave sleep suppression but not rapid eye movement sleep disturbance during nocturnal sleep plays a key role in the regulation of glucose (38).…”

Section: Results In Relation To Other Studiesmentioning

confidence: 88%

Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis of Prospective Studies

et al. 2015

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OBJECTIVEIt remains unclear how many hours of sleep are associated with the lowest risk of type 2 diabetes. This meta-analysis was performed to assess the dose-response relationship between sleep duration and risk of type 2 diabetes. RESEARCH DESIGN AND METHODSPubMed and Embase were searched up to 20 March 2014 for prospective observational studies that assessed the relationship of sleep duration and risk of type 2 diabetes. Both semiparametric and parametric methods were used. RESULTSTen articles with 11 reports were eligible for inclusion in the meta-analysis. A total of 18,443 incident cases of type 2 diabetes were ascertained among 482,502 participants with follow-up periods ranging from 2.5 to 16 years. A U-shaped dose-response relationship was observed between sleep duration and risk of type 2 diabetes, with the lowest risk observed at a sleep duration category of 7-8 h per day. Compared with 7-h sleep duration per day, the pooled relative risks for type 2 diabetes were 1.09 (95% CI 1.04-1.15) for each 1-h shorter sleep duration among individuals who slept <7 h per day and 1.14 (1.03-1.26) for each 1-h increment of sleep duration among individuals with longer sleep duration. CONCLUSIONS

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Section: Results In Relation To Other Studiesmentioning

confidence: 88%

Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis of Prospective Studies

et al. 2015

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“…The first study to examine the effect of experimental sleep manipulation upon insulin resistance in lean adolescents was conducted by Klingenberg and colleagues [45]. This randomized crossover study assessed 21 healthy males (mean age 16.…”

Section: Sleepmentioning

confidence: 99%

The Role of Genetic, Dietary and Lifestyle Factors in Pediatric Metabolic Syndrome: A Review of the Literature from Prenatal to Adolescence

Arora

Agouba

Sharara

et al. 2017

AJNE

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The metabolic syndrome (MetS) is described as a cluster of health conditions that are associated with an increased risk of cardiovascular disease. The clinical diagnosis of MetS in pediatrics is challenging due to differing criteria, although the estimated prevalence continues to rise. The increased prevalence of childhood obesity and insulin resistance, in both developed and developing countries, is believed to be a major contributor to MetS diagnosis in children. We review the current literature surrounding genetic predisposition, maternal influence, epigenetics, environmental and lifestyle factors pertaining to pediatric MetS with a specific emphasis on obesity and insulin resistance. We highlight and discuss recent, key studies in prenatal through to adolescent populations and review evidence suggesting that children may be pre-disposed to obesity and insulin resistance, prenatally. We also discuss several key lifestyle drivers of these conditions including poor nutrition and dietary habits, insufficient physical activity, use of electronic devices, over-consumption of caffeinated and/or sugar-sweetened beverages, as well as the importance of sleep during childhood and adolescence in relation to metabolic health. We conclude with recommendations for preventable methods to tackle this growing pediatric public health issue, which, if current trends continue, will undoubtedly compromise the health and longevity of the next adult generation.

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“…In healthy adolescents, two studies found that insulin sensitivity was negatively correlated to stage 1 non-rapid eye movement (non-REM) sleep, and positively to SWS duration [8,9]. Furthermore, in another population of healthy adolescents, partial sleep deprivation, with preserved SWS and a reduced amount of REM sleep, was followed by an increase in insulin resistance [10]. A correlation between short sleep duration and insulin resistance has also been found with actigraphic studies both in adolescents [11,12] and in younger children [13].…”

Section: @Erspublicationsmentioning

confidence: 99%

The puzzle of metabolic effects of obstructive sleep apnoea in children

Marrone

Bonsignore

2016

Eur Respir J

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@ERSpublicationsIn obese children with obstructive sleep apnoea insulin resistance is common while lipids do not show a clear pattern http://ow.ly/XNR9sIn adults, obstructive sleep apnoea (OSA) is often associated with metabolic alterations. Although obesity is a major culprit [1], large epidemiological studies have reported a metabolic risk associated with OSA that is independent of obesity. In particular, meta-analyses have shown that effective treatment of OSA by continuous positive airway pressure (CPAP) improves glycaemic control in both diabetic [2] and nondiabetic patients [3].Intermittent hypoxia is an important mechanism by which OSA affects metabolism, as supported by experimental observations showing that intermittent hypoxia negatively interferes with both glucose and lipid metabolism [4,5]. Altered sleep structure, as often found in OSA, may also play an important role. In adult humans, experimental sleep fragmentation [6] and deprivation of slow wave sleep (SWS) [7] decreased insulin sensitivity. In healthy adolescents, two studies found that insulin sensitivity was negatively correlated to stage 1 non-rapid eye movement (non-REM) sleep, and positively to SWS duration [8,9]. Furthermore, in another population of healthy adolescents, partial sleep deprivation, with preserved SWS and a reduced amount of REM sleep, was followed by an increase in insulin resistance [10]. A correlation between short sleep duration and insulin resistance has also been found with actigraphic studies both in adolescents [11,12] and in younger children [13].Paediatric OSA shows major differences compared with the adult disease [14]. First, the number of respiratory events and the degree of nocturnal hypoxaemia are usually lower in children than in adults. Second, sleep duration is physiologically longer in children than in adults and respiratory events, although possibly causing some sleep fragmentation, are associated with a sleep structure that appears to be better preserved than in adults. Third, duration of disease and exposure to additional risk factors for several complications is limited in children, as opposed to the decades of exposure to sleep disordered breathing (SDB) and risk factors typical of adult patients. Therefore, differences between adults and children with OSA could explain a different impact on metabolism. The picture is even more complex if we consider that paediatric disease has two main phenotypes: one typical of lean children with adenotonsillar hypertrophy, which usually occurs at a younger age and has a similar prevalence in both sexes; and one typical of obese children that is more similar to adult OSA and usually appears in adolescence, more often in males [15]. Onset of puberty is an additional factor known to affect metabolism in children, increasing insulin resistance at least in males [16]. The impact of all these variables, and the small sample size of several paediatric studies, probably contribute to the difficulties in clear interpretation of the apparently conflicting data available i...

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Acute Sleep Restriction Reduces Insulin Sensitivity in Adolescent Boys

Abstract: Klingenberg L; Chaput JP; Holmbäck U; Visby T; Jennum P; Nikolic M; Astrup A; Sjödin A. Acute Sleep Restriction Reduces Insulin Sensitivity in Adolescent Boys. 2013;36(7):1085-1090.

Cited by 103 publications

References 27 publications

Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis of Prospective Studies

Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis of Prospective Studies

The Role of Genetic, Dietary and Lifestyle Factors in Pediatric Metabolic Syndrome: A Review of the Literature from Prenatal to Adolescence

The puzzle of metabolic effects of obstructive sleep apnoea in children

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