Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus

Morais, Gilberto Santos; Souza, Vinícius Carolino; Machado-Silva, Wilcelly; Henriques, Adriane Dallanora; Alves, Andressa Melo; Morais, Danilo Barbosa; Nóbrega, Otávio Tolêdo; Brito, Ciro José; Silva, Roberto Jerônimo dos Santos

doi:10.2147/cia.s141716

Cited by 23 publications

(13 citation statements)

References 37 publications

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“…For instance, the plasma level of cfDNA was decreased in older adults following a combination of 6-month resistance training and nutritional supplementation (protein and micronutrients [e.g., vitamins C and E]) [ 35 ]. Furthermore, Morais Junior et al [ 36 ] examined acute effect of 1-week resistance exercise protocol in elderly subjects and found an increase in the circulating level of miR-146a-5p. However, there is currently limited literature examining a long-term resistance training program on the expression of inflammaging-related miR-146a in plasma from elderly people.…”

Section: Introductionmentioning

confidence: 99%

Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly

et al. 2021

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Aging-associated inflammation is characterized by senescent cell-mediated secretion of high levels of inflammatory mediators, such as microRNA (miR)-146a. Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA.

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Section: Introductionmentioning

confidence: 99%

Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly

et al. 2021

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“…It has also been evidenced that PA could modify blood glucose levels and glycosylated haemoglobin levels in nondiabetic elderly subjects [42]. One study has also demonstrated a significant increase in miR-146a (reduced concentrations of miR-146a contribute to a pro-inflammatory state associated with T2DM) with a decrease in serum blood glucose levels, which was more evident in the group of diabetic patients compared to healthy individuals after strength training [34]. In agreement with our results, literature shows that PA (both endurance and strength training) has an important role in the prevention and control of T2DM, producing acute and chronic physiological effects [55,56].…”

Section: Discussionmentioning

confidence: 98%

“…Reduced levels of the microRNAs miR-146a and miR-155 contribute to a pro-inflammatory state associated with T2DM. The effect of strength and cardiovascular training on T2DM patients has been investigated compared to a group of nondiabetic subjects, showing a significant increase of miR-146a and a decrease of blood glucose levels, which were more pronounced in diabetic patients after strength training [34]. In a Swedish study aimed at evaluating the wellbeing of the elderly, the Psychological General Wellbeing (PGWB) index has been put into correlation with several metabolic biomarkers, including the levels of several types of lipoproteins, BMI, and blood pressure.…”

Section: Effect Of Pa On Metabolic Parametersmentioning

confidence: 99%

Biohumoral Indicators Influenced by Physical Activity in the Elderly

Fossati

Torre

Borrione

et al. 2020

JCM

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In the scientific landscape, there is a growing interest in defining the role of several biomolecules and humoral indicators of the aging process and in the modifications of these biomarkers induced by physical activity and exercise. The main aim of the present narrative review is to collect the available evidence on the biohumoral indicators that could be modified by physical activity (PA) in the elderly. Online databases including Pubmed, Web of science (Medline), and Scopus were searched for relevant articles published in the last five years in English. Keywords and combination of these used for the search were the following: “biological”, “indicators”, “markers”, “physical”, “activity”, and “elderly”. Thirty-four papers were analyzed for inclusion. Twenty-nine studies were included and divided into four categories: cardiovascular (CV) biomarkers, metabolic biomarkers, inflammatory markers-oxidative stress molecules, and other markers. There are many distinct biomarkers influenced by PA in the elderly, with promising results concerning the metabolic and CV indexes, as a growing number of studies demonstrate the role of PA on improving parameters related to heart function and CV risk like atherogenic lipid profile. Furthermore, it is also a verified hypothesis that PA is able to modify the inflammatory status of the subject by decreasing the levels of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). PA seems also to be able to have a direct effect on the immune system. There is a strong evidence of a positive effect of PA on the health of elderly people that could be evidenced and “quantified” by the modifications of the levels of several biohumoral indicators.

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“…BMD is maintained by the precise balance between formation and reabsorption of calcium in all bones, a balance accomplished by osteoclasts and osteoblasts [5]. Current research shows that microRNAs (miRs) are important modulators of bone metabolism [6,7], with miRs as small non-protein-encoding RNA molecules containing 18 to 23 nucleotides in average, in one single-stranded chain [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Being responsible for the posttranscriptional silencing of thousands of genes, mostly by the inhibition of protein translation, miRs are associated with virtually all biological process, including the regulation of the mineral content in osseous structures [6][7][8][9][10]. Since the onset of the bone mineralization process, several in vitro studies point out developmental roles for miRs [11][12][13][14], whereas experimental studies show differential in situ expression of these elements in osteoporotic bones [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults

Nóbrega

Morais-Junior

Viana

et al. 2020

Journal of Aging Research

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The human aging is marked by several body changes, including in bone mineral density (BMD). Research shows that microRNAs are important modulators of bone metabolism. The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolute and relative scores of BMD in specific osseous site of Brazilian very-old adults. Forty noninstitutionalized and apparently healthy, very old (≥80 years) outpatients were eligible for research. Anthropometry, biochemistry, and densitometry measurements were performed along with coronary artery calcification (CAC) scores and tested across total circulating levels of microRNAs. As expected, the relative BMD scores for the lumbosacral region (L1 to S5) and for the femoral head and neck observed in the sample denote weakened bone architecture, compatible with prevalent osteopenia and osteoporosis. In this context, one single significant association was found, and negatively implicated the miR-34a-5p with both absolute (β = −0.36, P=0.001 for BMD) and relative (β = −0.43, P=0.001 for T-score) densitometry indexes of the femoral head (adjusted to sex and physical activity practice), but not with the other sites. No difference in total blood concentrations of the miRs was found according to CAC scores. Our findings indicate greater circulating levels for miR-34a-5p among very-old adults who display the lowest scores of BMD, being a finding consistent with a modest contribution of the miR (along with co-variables) to the mineralization of that site. Attesting clinical relevance of our findings demands forthcoming studies.

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Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus

Cited by 23 publications

References 37 publications

Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly

Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly

Biohumoral Indicators Influenced by Physical Activity in the Elderly

Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults

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