Acute stress alters the ‘default’ brain processing

Zhang, Wei; Hashemi, Mahur M.; Kaldewaij, Reinoud; Koch, Saskia B.J.; Beckmann, Christian F.; Klumpers, Floris; Roelofs, Karin

doi:10.1016/j.neuroimage.2019.01.063

Cited by 84 publications

(80 citation statements)

References 67 publications

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“…Interestingly, the DMN still maintained a stronger deactivation in the PostStress task phase, which is in line with previously reported changes in connectivity of the default mode network up to 2 hr after stress induction (Veer et al, 2011;Zhang et al, 2019). However, those stress-induced changes of activity in the dorsal attention, visual, and default mode network did not differ between IVP responders and non-responders.…”

Section: Discussionsupporting

confidence: 91%

Psychosocial stress reactivity habituates following acute physiological stress

Kühnel

Kroemer

Elbau

et al. 2020

Human Brain Mapping

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Acute and chronic stress are important factors in the development of mental disorders. Reliable measurement of stress reactivity is therefore pivotal. Critically, experimental induction of stress often involves multiple “hits” and it is an open question whether individual differences in responses to an earlier stressor lead to habituation, sensitization, or simple additive effects on following events. Here, we investigated the effect of the individual cortisol response to intravenous catheter placement (IVP) on subsequent neural, psychological, endocrine, and autonomous stress reactivity. We used an established psychosocial stress paradigm to measure the acute stress response (Stress) and recovery (PostStress) in 65 participants. Higher IVP‐induced cortisol responses were associated with lower pulse rate increases during stress recovery (b = −4.8 bpm, p = .0008) and lower increases in negative affect after the task (b = −4.2, p = .040). While the cortisol response to IVP was not associated with subsequent specific stress‐induced neural activation patterns, the similarity of brain responses Pre‐ and PostStress was higher IVP‐cortisol responders (t[64] = 2.35, p = .022) indicating faster recovery. In conclusion, preparatory stress induced by IVP reduced reactivity in a subsequent stress task by modulating the latency of stress recovery. Thus, an individually stronger preceding release of cortisol may attenuate a second physiological response and perceived stress suggesting that relative changes, not absolute levels are crucial for stress attribution. Our study highlights that considering the entire trajectory of stress induction during an experiment is important to develop reliable individual biomarkers.

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Section: Discussionsupporting

confidence: 91%

Psychosocial stress reactivity habituates following acute physiological stress

Kühnel

Kroemer

Elbau

et al. 2020

Human Brain Mapping

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“…Another recent study identified linear and quadratic relationships between the ventral attention, default mode, and executive control networks in the context of stressor-evoked heart rate reactivity but did not focus on the vmPFC (Young et al, 2017). Similarly, a study in 335 healthy participants demonstrated a relationship between individual cortisol responses and reductions in DMN connectivity in response to a mental and physical stress task (Zhang et al, 2019). A study focusing on whole brain network efficiency reported a relationship between increased levels of cortisol responses to stress and decreased network efficiency during stress .…”

Section: Discussionmentioning

confidence: 99%

Ventromedial prefrontal cortex connectivity during and after psychological stress in women

et al. 2019

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The ventromedial prefrontal cortex (vmPFC) integrates sensory, affective, memory‐related, and social information from diverse brain systems to coordinate behavioral and peripheral physiological responses according to contextual demands that are appraised as stressful. However, the functionality of the vmPFC during stressful experiences is not fully understood. Among 40 female participants, the present study evaluated (a) functional connectivity of the vmPFC during exposure to and recovery following an acute psychological stressor, (b) associations among vmPFC functional connectivity, heart rate, and subjective reports of stress across individuals, and (c) whether patterns of vmPFC functional connectivity were associated with distributed brain networks. Results showed that psychological stress increased vmPFC functional connectivity with individual brain areas implicated in stressor processing (e.g., insula, amygdala, anterior cingulate cortex) and decreased connectivity with the posterior cingulate cortex and thalamus. There were no statistical differences in vmPFC connectivity to individual brain areas during recovery, as compared with baseline. Spatial similarity analyses revealed stressor‐evoked increased connectivity of the vmPFC with the so‐called dorsal attention, ventral attention, and frontoparietal networks, as well as decreased connectivity with the default mode network. During recovery, vmPFC connectivity increased with the frontoparietal network. Finally, individual differences in heart rate and perceived stress were associated with vmPFC connectivity to the ventral attention, frontoparietal, and default mode networks. Psychological stress appears to alter network‐level functional connectivity of the vmPFC in a manner that further relates to individual differences in stressor‐evoked cardiovascular and affective reactivity.

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“…The neurobiology of stress response is still under investigation. Adaptive reactions to acute stress include shifts in the large-scale brain networks (salience (SN), central executive (CEN), and default mode networks (DMN)) under tasks and without ongoing task demands [65]. For children, anxious and uncontained parenting was associated with higher cortisol levels and with reduced DMN connectivity in preadolescence [66].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Mentalizing and Working Conditions in Health Care

Steinmair

Richter

Löffler‐Stastka

2020

IJERPH

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Mentalizing describes the human ability to comprehend one’s own and others’ mental states and is seen as one of the core competencies of psychotherapists. Current research has emphasized the importance of both early dyadic attachment as well as broader sociocultural environmental input on the development of mentalizing. This study investigates whether mentalizing skills, operationalized via reflective functioning (RF), might be influenced by training and working conditions. This study was a matched case-control comparison, cross-sectional study. RF was assessed in a total of 10 psychotherapy trainees working in private practice at the beginning (group A; n = 5) and end (group B; n = 5) of their psychotherapy training (training association: Gestalt Therapy, Institute of Integrative Gestalttherapy Vienna) and in a total of 40 health professionals (institution: General Hospital Vienna—Social Medical Center South, Vienna, Department of Psychiatry, acute psychiatric ward) at the beginning of (group C; n = 20) and without (group D; n = 20) mentalization based therapy training. The participants differed from each other regarding their training, but participants of the same institution were matched. RF scores were significantly higher in group A and B than in group C and D (A,C: p = 0.0065, Odds Ratio (OR): 0.0294; A,D: p = 0.0019, OR: 0.0132; B,C: p = 0.0065, OR: 0.0294, B,D: p = 0.0019, OR: 0.0132). RF scores were not significantly different among groups A and group B (A,B: p > 0.9999) or between groups C and D (C,D: p = 0.6050). The current study suggests that mentalizing skills might be rather slow to improve by training, but that they might be influenced by the context.

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Acute stress alters the ‘default’ brain processing

Cited by 84 publications

References 67 publications

Psychosocial stress reactivity habituates following acute physiological stress

Psychosocial stress reactivity habituates following acute physiological stress

Ventromedial prefrontal cortex connectivity during and after psychological stress in women

Relationship between Mentalizing and Working Conditions in Health Care

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