Acute stress enhances associative learning via dopamine signaling in the ventral lateral striatum

Stelly, Claire E.; Tritley, Sean C.; Rafati, Yousef; Wanat, Matthew J.

doi:10.1101/2019.12.18.881417

Cited by 3 publications

(9 citation statements)

References 57 publications

(51 reference statements)

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“…We monitored head entries into the food tray across training sessions. Conditioned responding was quantified as the change in the rate of head entries during the 5 s CS relative to the 5 s preceding the CS delivery [8,15]. We also quantified the latency to initiate a head entry during the CS.…”

Section: Methodsmentioning

confidence: 99%

“…The injectors were removed 1 min after the infusion ended. Behavioral sessions commenced 30 min after the microinjections [15,16].…”

Section: Methodsmentioning

confidence: 99%

“…Indwelling carbon fiber microelectrodes were connected to a head-mounted amplifier to monitor dopamine release in behaving rats using fast-scan cyclic voltammetry [8,14,15,17-19]. During voltammetric scans, the potential applied to the carbon fiber was ramped in a triangular waveform from −0.4 V (vs. Ag/AgCl) to +1.3 V and back at a rate of 400 V/s.…”

Section: Methodsmentioning

confidence: 99%

“…Dopamine was chemically verified by obtaining high correlation of the cyclic voltammogram during a reward-related event with that of a dopamine standard (correlation coefficient r 2 ≥ 0.75 by linear regression). Voltammetry data for a session were excluded from analysis if the detected voltammetry signal did not satisfy the chemical verification criteria [8,15,15]. Dopamine was isolated from the voltammetry signal using chemometric analysis [20] with a standard training set accounting for dopamine, pH and drift.…”

Section: Methodsmentioning

confidence: 99%

“…CS-evoked dopamine release was quantified as the mean dopamine response during the 5 s CS relative to the 5 s prior to the CS delivery [8,15]. The slope of the CS response was calculated as the difference in the mean dopamine levels during the peak (1.5 – 2 s) and the end of the CS (4.5 – 5 s) as a function of time.…”

Section: Methodsmentioning

confidence: 99%

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Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell

Stelly

Girven

Lefner

et al. 2020

Preprint

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Dopamine neurons respond to cues to reflect the value of associated outcomes. These cue-evoked dopamine responses can encode the relative rate of reward in rats with extensive Pavlovian training. Specifically, a cue that always follows the previous reward by a short delay (high reward rate) evokes a larger dopamine response in the nucleus accumbens (NAc) core relative to a distinct cue that always follows the prior reward by a long delay (low reward rate). However, it was unclear if these reward rate dopamine signals are evident during early Pavlovian training sessions and across NAc subregions. To address this, we performed fast-scan cyclic voltammetry recordings of dopamine levels to track the pattern of cue and reward-evoked dopamine signals in the NAc core and medial NAc shell. We identified regional differences in the progression of cue-evoked dopamine signals. However, reward rate encoding was not evident in either the NAc core or NAc shell during early training sessions. Pharmacological experiments found that dopamine-sensitive conditioned responding emerged in the NAc core before the NAc shell. Together, these findings illustrate regional differences in NAc dopamine release and its control over behavior during early Pavlovian learning.

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Section: Methodsmentioning

confidence: 99%

“…The injectors were removed 1 min after the infusion ended. Behavioral sessions commenced 30 min after the microinjections [15,16].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell

Stelly

Girven

Lefner

et al. 2020

Preprint

Self Cite

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Mesolimbic dopamine adapts the rate of learning from action

Coddington

Dudman

2021

Preprint

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Recent success in training artificial agents and robots derives from a combination of direct learning of behavioral policies and indirect learning via value functions. Policy learning and value learning employ distinct algorithms that depend upon evaluation of errors in performance and reward prediction errors, respectively. In animals, behavioral learning and the role of mesolimbic dopamine signaling have been extensively evaluated with respect to reward prediction errors; however, to date there has been little consideration of how direct policy learning might inform our understanding. Here we used a comprehensive dataset of orofacial and body movements to reveal how behavioral policies evolve as naive, head-restrained mice learned a trace conditioning paradigm. Simultaneous multi-regional measurement of dopamine activity revealed that individual differences in initial reward responses robustly predicted behavioral policy hundreds of trials later, but not variation in reward prediction error encoding. These observations were remarkably well matched to the predictions of a neural network based model of behavioral policy learning. This work provides strong evidence that phasic dopamine activity regulates policy learning from performance errors in addition to its roles in value learning and further expands the explanatory power of reinforcement learning models for animal learning.

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Relationship between stressful life events, coping styles, and schizophrenia relapse

Wang

Zhu

Xiao-jian

et al. 2021

Int J Mental Health Nurs

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This study aimed to explore the relationship between stressful life events, coping styles, and schizophrenia relapse. The sample for this study included 248 patients with schizophrenia from a psychiatric outpatient clinic in Hunan Province, China. Stressful life events, occurrence of schizophrenia relapse, and coping style were assessed by the Scale for the Social Readjustment Rating, Brief Psychiatric Rating Scale, and Simplified Coping Style Questionnaire, respectively. Spearman correlation analysis and binary logistic regression analysis were adopted to explore the relationships among coping styles, schizophrenia relapse, and stressful life events. Stressful life events and negative coping exhibited significant positive association with schizophrenia relapse, while positive coping exhibited a significant negative association with schizophrenia relapse. Stressful life events and positive coping exerted significant effects on schizophrenia relapse, while negative coping did not. We also found that both positive coping and negative coping have moderating effects on the relationship between stressful life events and schizophrenia relapse, but the relationship is weak. The study highlighted the importance of interventions designed to reduce stressful life events, promote positive coping, and address negative coping in patients with schizophrenia.

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Acute stress enhances associative learning via dopamine signaling in the ventral lateral striatum

Cited by 3 publications

References 57 publications

Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell

Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell

Mesolimbic dopamine adapts the rate of learning from action

Relationship between stressful life events, coping styles, and schizophrenia relapse

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