2018
DOI: 10.1101/294645
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Acute-stress impairs cytoprotective mechanisms through neural inhibition of the insulin pathway

Abstract: Persistent activation of the "fight-or-flight" response accelerates aging and increases the susceptibility to disease. We show that repeated induction of the C. elegans flight response inhibits conserved cytoprotective mechanisms. This acute-stress response activates neurons that release tyramine, the invertebrate analog of adrenaline/noradrenaline. Tyramine stimulates the DAF-2/Insulin/IGF-1 pathway and precludes the nuclear translocation of the DAF-16/FOXO transcription factor through the activation of an ad… Show more

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References 89 publications
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