Acute, subacute toxicity and mutagenic effects of anacardic acids from cashew (Anacardium occidentale Linn.) in mice

Plants used during maternity, menstrual cycle and other women's health conditions among Brazilian cultures

“…anti-inflammatory for the ovaries and / or uterus, abortive, for sexual impotence/aphrod isiac Administration via oral of extract to mice had LD 50 of 2.154 g/kg (Okonkwo et al, 2010) The LD50 of the hexane extract, determined in mice after oral administration was 16 g/kg (Tédong, 2007) Hepatotoxic effect (increased the serum levels of alanine aminotransaminase and aspartate aminotransaminase) in mice (Okonkwo, 2010) and dogs (de Melo, 2006) Anorexia, diarrhea, and syncope in mice with doses higher than 6g/kg (Tédong, 2007) Single oral dose of anacardic acid (2000 mg/kg) has not produced biochemical and hematological alterations in BALB/c mice (Carvalho, 2011) NDF…”

In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine

“…These observations, as well as the serum levels of bilirubin and transaminases, established the absence of hepatocellular damage induced by the extracts. Histological analysis and biochemical parameters are essential for evaluating the toxicological risk of substances with biological activity because any changes in one of these parameters in animal studies can provide a high predictive value of potential damage in humans (Carvalho et al, 2011;Olson et al, 2000;Silva et al, 2011).…”

Addition of anacardic acid as antioxidants in broiler chicken mortadella

“…Trevisan et al (2006), when analyzing the antioxidant capacity of anacardic acids, cardanols and cardols present in the cashew apple, nuts and CNSL, noted that anacardic acids have higher antioxidant capacity when compared to cardols and cardanols. For the toxicological aspect of the anacardic acids, Carvalho et al (2011) effects of anacardic acids from cashew in mice. These authors, concluded that doses less than 300 ppm (parts per million) did not produce biochemical and hematological alterations in mice.…”