Acute, subchronic, and chronic toxicity of chlordecone

Larson, Paul; Egle, John L.; Hennigar, Gordon R.; Lane, Richard W.; Borzelleca, Joseph F.

doi:10.1016/s0041-008x(79)80005-8

Cited by 62 publications

(54 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Direct exposure to a variety of environmental contaminants has been shown to cause one or more of these abnormalities. These include benomyl (30)(31)(32), carbenzadim (33,34), chlordecone (35), methoxychlor (31), methylmercury (36), 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) (37), and some PCB congeners (38). Exposure to several chemicals, including fenarimol, methylmercury, and TCDD, has resulted in decreased male fertility (37,39,40).…”

Section: Discussionmentioning

confidence: 99%

Reproductive Impairment in the Florida Panther: Nature or Nurture?

Facemire¹,

Gross²,

Guillette³

1995

Environmental Health Perspectives

200

111

View full text Add to dashboard Cite

Many of the remaining members of the endangered Florida panther (Felis concolor coryi) population suffer from one or more of a variety of physiological, reproductive, endocrine, and immune system defects including congenital heart defects, abnormal sperm, low sperm density, cryptorchidism, thyroid dysfunction, and possible immunosuppression. Mercury contamination, determined to be the cause of death of a female panther in 1989, was presented as the likely cause of thyroid dysfunction. As genetic diversity in the species was less than expected, all of the other abnormalities have been attributed to inbreeding. However, exposure to a variety of chemical compounds, especially those that have been identified as environmental endocrine disrupters (including mercury, p,p'-DDE, and polychlorinated biphenyls), has elicited all of the listed abnormalities in other species. A number of these contaminants are present in South Florida. An exposure pathway has been identified, and evidence presented in this paper, including the fact that there appears to be no significant difference between serum estradiol levels in males and females, suggests that many male panthers may have been demasculinized and feminized as a result of either prenatal or postnatal exposure. Thus, regardless of the effects of inbreeding, current evidence seems to indicate that environmental contaminants may be a major factor contributing to reproductive impairment in the Florida panther population. -Environ Health Perspect 1 03(Suppl 4): 79-86 (1995)

show abstract

Section: Discussionmentioning

confidence: 99%

Reproductive Impairment in the Florida Panther: Nature or Nurture?

Facemire¹,

Gross²,

Guillette³

1995

Environmental Health Perspectives

200

111

View full text Add to dashboard Cite

show abstract

“…The combined oral LD50 for male and female rats was 125 mg/kg (Gaines, 1969). LD50 values for male rabbits and dogs (sex not specified) were 71 and 250 mg/kg, respectively (Larson et al, 1979b). A single oral dose of 110 mg/kg resulted in 25% mortality in pregnant mice (Kavlock et al, 1985).…”

Section: ~-mentioning

confidence: 99%

“…Single-dose oral LD50 values for chlordecone in rats were reported to be 126 mg/kg in females (Larson et al, 1979b) and between 91.3 (Pryor et al, 1983) and 132 mg/kg (Larson et al, 1979b) in males. The combined oral LD50 for male and female rats was 125 mg/kg (Gaines, 1969).…”

Section: ~-mentioning

confidence: 99%

“…At 10 mg/kg/day, all male mice died by day 33 of dosing (Fujimori et al, 1983). Survival was decreased in female rats at 1.25 mg/kg/day in a two-year feeding study (Larson et al, 1979b) and in both male and female rats at 1.2-1.3 mg/kg/day in an 80-week feeding study (NCI, 1976). Male mice showed decreased survival at 2.6 mg/kg/day and above in an 80-week feeding study (NCI, 1976).…”

Section: ~-mentioning

confidence: 99%

“…Routine histopathological examination of the lungs of rats in both 90-day and two-year feeding studies with doses as high as 4 mg/kg/day showed no adverse effects. Also, routine histopathological examination of the lungs of dogs exposed to doses as high as 0.625 mg/kg/day in a two-year feeding study showed no effects (Larson et al, 1979b). These studies are limited in that it is unclear how many lung tissue samples were actually examined, and the dog study also is limited in that the number of animals used (two/sex/dose) was low.…”

Section: ~-mentioning

confidence: 99%

See 2 more Smart Citations

Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

View full text Add to dashboard Cite

This document provides public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of mirex and chlordecone. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. Additional substances will be profiled in a series of manuscripts to follow.

show abstract

Miscellaneous Chlorinated Hydrocarbon Pesticides

Freeman,

Loccisano

2023

Patty's Toxicology

View full text Add to dashboard Cite

This chapter presents information on chlorinated hydrocarbon insecticides. The chlorinated hydrocarbon insecticides belong to a structural class containing carbon, hydrogen, and chlorine; some contain oxygen. Although many pesticides can meet this basic definition, organochloride hydrocarbons, the focus of this chapter, share basic characteristics of high persistence (where persistence is defined as halflife greater than 2 months in water or 6 months in soil sediment), low polarity, low aqueous solubility and high lipid solubility. This group contains pesticides such as dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethane (DDD), lindane. chlordane, aldrin, dieldrin, endrin, heptachlor, toxaphene, and mirex. Based on their persistence in the environments, chlorinated hydrocarbon insecticides are considered persistent organic pollutants (POPs).

show abstract

Acute, subchronic, and chronic toxicity of chlordecone

Cited by 62 publications

References 18 publications

Reproductive Impairment in the Florida Panther: Nature or Nurture?

Reproductive Impairment in the Florida Panther: Nature or Nurture?

Atsdr Evaluation of Health Effects of Chemicals

Miscellaneous Chlorinated Hydrocarbon Pesticides

Contact Info

Product

Resources

About