Acute Syphilitic Posterior Placoid Chorioretinitis

Optical coherence tomography and indocyanine green angiography findings in acute syphilitic posterior placoid choroidopathy: case report

“…In accordance with other studies, fluorescein angiogram showed irregular initial hyperfluorescence with hypofluorescent spots and late staining of the lesion (3,5,7) . The lesion was hypofluorescent on ICGA, with the characteristic leopard skin pattern (3) beyond its limits in OD. Interestingly, leopard spots in the peripapillary area and in the posterior pole were also present in OS, without any correspondence in fundus examination.…”

“…Gass et al described acute syphilitic posterior placoid chorioretinitis (ASPPC) in six patients with evidence of secondary syphilis that showed one or more large macular or peripapillary placoid lesions. It was proposed that the angiographic features of this entity were sufficiently conspicuous to suggest the diagnosis of secondary syphilis (3) . Herein we report the optical coherence tomography (OCT) and indocyanine green angiography (ICGA) findings in a patient with ASPPC.…”

Syphilitic retinitis and panuveitis simulating acute retinal necrosis: case report

“…Misdiagnosed cases like this were reported, and many diseases may simulate ARN, including toxoplasmosis, fungal endophthalmitis, Behçet disease and ocular lymphoma (8) . However, even with the possible diagnosis of syphilis or other diseases in mind, due to the severity of necrotizing viral retinitis, for some the initial treatment remains the use of antiviral therapy until the definitive diagnosis (1) , that may require vitreous or aqueous humor aspirates with antibody dosage, polymerase chain reaction, cytology and cultures for specific agent (9) . The acute syphilitic posterior placoid choriorretinitis was first described in 1990 (9) , and the clinical picture was initially thought to be due some kind of immunosupression, like HIV infection or corticosteroid usage.…”

Ocular syphilis: the new epidemic

“…Neuroretinitis may occur, and placoid chorioretinitis of the macula is said to be characteristic in those who are HIV positive. 4 Syphilis serology should be arranged in cases of intractable uveitis of uncertain origin, 5 where there is retinitis or retinal vasculitis, and where uveitis presents with a skin rash and/or headache. Diagnosis of active syphilis requires a combination of Treponema-specific tests and nontreponemal tests.…”