Acute systemic vanadate poisoning presenting as cerebrovascular ischemia with prolonged reversible neurological deficits (PRIND)

Topical vanadate improves tensile strength and alters collagen organisation of excisional wounds in a mouse model

“…Finally, although vanadate is known to be toxic at very high doses, by using low-volume local injections, we minimised the risk of systemic toxicity and indeed observed no morbidity or mortality in any of the experimental mice, although this may be a factor to consider when adjusting dosing for larger bodied animals. 66,67 In conclusion, we demonstrate that locally administered vanadate significantly improved the tensile strength of early and remodelling wounds. This improvement was likely mediated in part through vanadate's modulatory effect on both collagen deposition and organisation in the healing wound.…”

“…As previously mentioned, given vanadate's profound impact on collagen organisation and deposition, additional investigations into the causative pathways and mechanisms through which vanadate alters collagen deposition and ultrastructure would also help to better characterise the wound healing process. Finally, although vanadate is known to be toxic at very high doses, by using low‐volume local injections, we minimised the risk of systemic toxicity and indeed observed no morbidity or mortality in any of the experimental mice, although this may be a factor to consider when adjusting dosing for larger bodied animals 66,67 …”

Fatal poisoning by vanadium

“…We are facing a rare case of autolysis with an ammonium salt of vanadium. Schlake and collaborators [3] reported a case of a 22-year-old woman developing nausea, vomiting and diarrhea 2 h after ingesting 10-15 g of ammonium metavanadate. Endoscopy exploration revealed erosive gastritis.…”

Ванадий: Биологическая Роль, Токсикология И Фармакологическое Применение

“…Патоморфологические исследования и аутопсия выявили признаки асфиксии внутренних органов и эрозивный гастрит. судя по этому и по ряду других примеров острой интоксикации неорганическими солями ванадия у человека, основными признаками острого отравления являются желудочно-кишечные расстройства (тошнота, рвота, диарея) [185], воспалительные реакции кожи и слизистых оболочек глаз (конъюнктивиты), глотки, верхних дыхательных путей (мокрый кашель, хрипы, риниты, бронхиты), легочная асфиксия и вазоконстрикция бронхов [59,135], гипогликемия, острая почечная и печеночная недостаточность, аллергические реак-ции (экзема, астмоподобные состояния), лейкопения и анемия [12,90].…”