Acute thyrotoxicosis after SCT

Waele, S De; Bruel, Annick Van den; Selleslag, Dominik; Berghe, Ivo Van Den; Decallonne, Brigitte

doi:10.1038/bmt.2008.374

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…2 There have been previous reports of thyrotoxicosis and hypothyroidism after transplantation; however, histopathological findings and detailed mechanisms remain unclear. 3 In the present study, we encountered a case in which histopathology suggested an immune reaction in the thyroid gland that may have been caused by acute GVHD. The patient was a man in his 20s with acute myeloid leukemia (M5a) .…”

Section: Introductionmentioning

confidence: 81%

Acute thyrotoxicosis-like graft-versus-host disease after cord blood transplantation

Kawata

Bandai

Koba

et al. 2023

Japanese Journal of Transplantation and Cellular Therapy

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Reports of thyrotoxicosis and hypothyroidism occurring immediately after allogeneic stem cell transplantation are limited, and the detailed mechanisms remain unclear. Here, we present the case of a man in his 20s with thyrotoxicosis and hypothyroidism that occurred early after cord blood transplantation(CBT) , with histopathology suggesting an immune reaction in the thyroid gland. The patient had acute myeloid leukemia and underwent a second CBT procedure. The patient developed thyrotoxicosis on day 43. The patient's condition initially improved with increasing immunosuppressive drug doses; however, he later developed hypothyroidism and required thyroid hormone replacement therapy. Since conventional subacute thyroiditis, Graves' disease, and Hashimoto's thyroiditis were excluded due to the lack of histological evidence and autoantibodies, acute graft-versus-host disease (GVHD)was considered the main cause of thyroiditis. The possibility of even minor post-transplant thyroid function abnormalities is more common than expected and further studies are required.

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Section: Introductionmentioning

confidence: 81%

Acute thyrotoxicosis-like graft-versus-host disease after cord blood transplantation

Kawata

Bandai

Koba

et al. 2023

Japanese Journal of Transplantation and Cellular Therapy

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“…3 HHV6 replication occurs in approximately half of allogeneic HSCT recipients and may cause fever, skin rash, interstitial pneumonia, and encephalitis. 4,5 To date, however, HHV6associated pleurisy has not been recognized as a complication of HSCT. In this report, we describe an adult HSCT recipient who developed HHV6-associated pleurisy after an unrelated cord blood transplantation (CBT).…”

Section: Introductionmentioning

confidence: 99%

A Chronic Graft-versus-host Disease Case after Improvement of Basedow's Disease developed after Allogeneic Bone Marrow Transplantation

Sakaguchi

Satake

Shimizu

et al. 2016

Journal of Hematopoietic Cell Transplantation

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“…[8][9][10][11] Post-HSCT hyperthyroidism is uncommon, presenting primarily with temporary/subclinical manifestations. [12][13][14][15] Alemtuzumab, an immune suppressant anti-CD52 antibody incorporated into conditioning regimens has been implicated in autoimmune thyroid dysfunction. 16 Alemtuzumab-based treatment of multiple sclerosis (MS) can result in Graves' disease (GD) in 20% of patients.…”

mentioning

confidence: 99%

“…35 Hyperthyroidism is uncommon following pediatric HSCT. 9,[12][13][14][15] GVHD is a risk factor for thyroid dysfunction. 36,37 Autoimmune thyroid dysfunction also affects 20%-30% of patients treated with alemtuzumab, typically for MS, and manifests as GD in 60%-70% of those affected.…”

mentioning

confidence: 99%