Acute toxicity and environmental risk of teflubenzuron toDaphnia magna,Poecilia reticulataandLemna minorin the absence and presence of sediment

Medeiros, Louise S; Souza, José Paulo de; Winkaler, Elissandra Ulbricht; Carraschi, Silvia Patrícia; Cruz, Claudinei da; Souza-Júnior, Severino C; Machado-Neto, J. G.

doi:10.1080/03601234.2013.775000

Cited by 17 publications

(6 citation statements)

References 16 publications

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“…It should be noted that in the present study, the estimated LC50 for the effect of TEF on D. magna survival in the ≤24-hpr group was 16.8 μg/L, which was 60 times higher than previously reported (Medeiros et al, 2013). This large discrepancy might arise from the use of a commercial formulation of TEF by Medeiros and coworkers.…”

Section: Resultscontrasting

confidence: 83%

Age and Synchronization of Daphnia magna Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests

Schmid

Rundberget

Shang

et al. 2023

Enviro Toxic and Chemistry

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The standard Daphnia sp. acute toxicity test for assessing the adverse effects of chemicals on aquatic invertebrates stipulates the use of neonates that are ≤24 h old (hours post release [hpr]) at the start of the exposure. However, when one is assessing acute effects of chemicals interfering with endocrine relevant-processes such as molting, both age synchronization and absolute age can influence the test outcome, because the occurrence of molting and associated mortality is highly time specific. Hence, a 24-h age synchronization window may mask the real effects of these compounds. To explore the influence of age synchronization and absolute age in standard acute toxicity tests, we exposed D. magna from different synchronization windows and absolute ages (≤4, 4-8, 8-12, ≤12, and ≤24 hpr at the beginning of the exposure) to 0.5-12 µg/L of the chitin synthesis inhibitor (CSI) teflubenzuron (TEF) using the Organisation for Economic Co-operation and Development test guideline 202 (Daphnia sp. 48 h immobilization test). Our results show significant differences in 48-h median lethal concentrations between animals with a synchronization window of ≤4 hpr (2.9 µg/L) and longer synchronization windows such as ≤12 hpr (5.1 µg/L) and ≤24 hpr (16.8 µg/L). A concurrent decreasing trend in molting median effect concentrations was observed for the same synchronization windows: ≤4 hpr (4.0 µg/L), ≤12 hpr (5.9 µg/L), and ≤24 hpr (30.0 µg/L). Together, our results show that both synchronization and absolute age are determinant factors for the sensitivity of D. magna to TEF. A narrow synchronization window (e.g., ≤4 hpr) may provide a more conservative estimate of TEF toxicity and should be considered when one is performing standardized toxicity tests for molting-disrupting compounds such as TEF.

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Section: Resultscontrasting

confidence: 83%

Age and Synchronization of Daphnia magna Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests

Schmid

Rundberget

Shang

et al. 2023

Enviro Toxic and Chemistry

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“…For instance, the 96 h-EC 50 values of thiamethoxam to Navicula pelliculosa, Raphidocelis subcapitata , Lemna gibba , and Anabaena flos-aquae were greater than 90 mg/L . The 7 d-EC 50 of teflubenzuron to Lemna minor even exceeded 1100 mg/L . However, several researches showed that phenylpyrazole pesticides were highly toxic to freshwater algae.…”

Section: Resultsmentioning

confidence: 99%

“…42 The 7 d-EC 50 of teflubenzuron to Lemna minor even exceeded 1100 mg/L. 43 However, several researches showed that phenylpyrazole pesticides were highly toxic to freshwater algae. The 72 h-EC 50 of rac-fipronil to Scenedesmus obliquus was 0.54 mg/L, and R-fipronil was found to be approximately 5 times as toxic as S-fipronil with 72 h-EC 50 values of 0.29 and 1.50 mg/L.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Biodegradation of Chiral Flufiprole in Chlorella pyrenoidosa: Kinetics, Transformation Products, and Toxicity Evaluation

Gao

Wang

Jiang

et al. 2020

J. Agric. Food Chem.

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Pesticide pollution of surface water represents a considerable risk for algae and thus affects the structure and stability of aquatic ecosystems. To investigate the risk of flufiprole to phytoplankton, the digestion and uptake of flufiprole as well as the toxic effects of flufiprole enantiomers and the six metabolites to Chlorella pyrenoidosa were investigated. Flufiprole enantiomers were mainly metabolized to flufiprole amide and detrifluoromethylsulfinyl flufiprole in culture medium, while various metabolites were formed in algae, notably the amide derivative and fipronil. Chlorella pyrenoidosa showed a strong absorption capacity for the flufiprole series. The EC50 values (96 h) indicated that fipronil was the most toxic compound, approximately 5 times as toxic as rac-flufiprole. R-flufiprole was more toxic than S-flufiprole. The contents of chlorophylls, malondialdehyde (MDA), reactive oxygen species (ROS), and total antioxidant capacity (T-AOC) were significantly altered by the chemicals in most cases, especially fipronil. Our results supported the potential detrimental effect of the metabolites of flufiprole on algae.

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“…Few data are available on dose descriptors for flubenzurons, particularly on non‐targeted marine crustaceans and after oral administration of the pesticide. For the cladocera Daphnia magna , teflubenzuron (48 hours EC 50 : 0.26 μg/L) was 27.3 times more toxic than diflubenzuron (48 hours EC 50 : 7.1 μg/L) when exposed to the pesticide dissolved in water (Medeiros et al, ). A no‐observed‐effect concentration of 0.062 μg/L was found for D. magna after 21 days of waterborne exposure (Scheepmaker, ).…”

Section: Introductionmentioning

confidence: 99%

Whole‐animal accumulation, oxidative stress, transcriptomic and metabolomic responses in the pink shrimp (Pandalus montagui) exposed to teflubenzuron

Aulin

Samuelsen

Hannisdal

et al. 2018

J of Applied Toxicology

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The benzoylurea chitin synthesis inhibitor teflubenzuron, widely used against sea lice in North Atlantic aquaculture, may pose an environmental threat to non‐targeted crustaceans. In this experiment, laboratory acclimated pink shrimp (Pandalus montagui), a species found in fjords with Atlantic salmon farming, were exposed to dietary teflubenzuron for 46 days (control; low dose: 0.01 μg/g; high dose: 0.1 μg/g). The exposure doses represent 0.1% and 1% of a standard treatment dose for Atlantic salmon. Mortality and prevalence of deformities, pharmacokinetics, oxidative stress and transcriptomic and metabolomic profiling were used to assess the response to teflubenzuron exposure. Mortality in the high‐dose group was 25% (five of 20 individuals). No control or low‐dose group shrimps died. Phenotypic responses,i.e., leg deformities (0 control, 6 low, 8 high) and cloudy eyes (0 control, 3 low, 7 high), were observed in some surviving shrimps (control n = 15, low n = 17, high n = 15). Accumulated levels of teflubenzuron in shrimps from the high‐dose group ranged from 4.7 to 369 ng/g wet weight. Transcriptomic profiling showed very few significantly altered genes in the exposed shrimps. Teflubenzuron‐induced changes to the metabolome pointed to well‐known effects of benzoylurea agents, with reduced levels of N‐acetylglucosamine indicating an effect on chitin synthesis. The metabolomic profiling showed that teflubenzuron exposure was associated with reduced energy metabolism. Some metabolites pointed to increased necrosis and/or bacterial overgrowth in the teflubenzuron‐exposed shrimps. In conclusion, this study shows that teflubenzuron causes phenotypic effects in P. montagui exposed to 0.1% of the treatment dose given to Atlantic salmon.

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Acute toxicity and environmental risk of teflubenzuron toDaphnia magna,Poecilia reticulataandLemna minorin the absence and presence of sediment

Cited by 17 publications

References 16 publications

Age and Synchronization of Daphnia magna Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests

Age and Synchronization of Daphnia magna Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests

Biodegradation of Chiral Flufiprole in Chlorella pyrenoidosa: Kinetics, Transformation Products, and Toxicity Evaluation

Whole‐animal accumulation, oxidative stress, transcriptomic and metabolomic responses in the pink shrimp (Pandalus montagui) exposed to teflubenzuron

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