Acute Toxicity and Etho-toxicity of Three Insecticides Used for Mosquito Control on Amphibian Tadpoles

Junges, Celina María; Maglianese, Mariana; Peltzer, Paola M.; Attademo, Andrés M.

doi:10.1007/s11270-017-3324-6

Cited by 22 publications

(12 citation statements)

References 41 publications

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“…A concentration of 10 μL/L caused death of all the subjects, but there was no favorable expression in respect to the enzymes [36]. A more complete study carried out by Junges [37] investigated the lethal and sublethal effects of three insecticides (temephos, Bacillus thuringiensis var. Israelensis and permethrin) on amphibians ( Rhinella arenarum, Rhinella fernandezae and Physalaemus albonotatus ) and temephos was the second most toxic and all insecticides were observed to produce behavioral changes in tadpoles independent of the dose-response.…”

Section: Resultsmentioning

confidence: 99%

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos

et al. 2019

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Aedes aegypti (Linnaeus, 1762; Diptera: Culicidae) is the main vector transmitting viral diseases such as dengue fever, dengue haemorrhagic fever, urban yellow fever, zika and chikungunya. Worldwide, especially in the Americas and Brazil, many cases of dengue have been reported in recent years, which have shown significant growth. The main control strategy is the elimination of the vector, carried out through various education programs, to change human habits, but the most usual is biological control, together with environmental management and chemical control. The most commonly insecticide used is temephos (an organophosphorus compound), but Aedes aegypti populations have shown resistance and the product is highly toxic, so we chose it as a template molecule to perform a ligand-based virtual screening in the ChemBrigde (DIVERSet-CL subcollection) database, searching for derivatives with similarity in shape (ROCS) and electrostatic potential (EON). Thus, fourty-five molecules were filtered based on their pharmacokinetic and toxicological properties and 11 molecules were selected by a molecular docking study, including binding affinity and mode of interaction. The L46, L66 and L68 molecules show potential inhibitory activity for both the insect (−9.28, −10.08 and −6.78 Kcal/mol, respectively) and human (−6.05, 6.25 and 7.2 Kcal/mol respectively) enzymes, as well as the juvenile hormone protein (−9.2; −10.96 and −8.16 kcal/mol, respectively), showing a significant difference in comparison to the template molecule temephos. Molecules L46, L66 and L68 interacted with important amino acids at each catalytic site of the enzyme reported in the literature. Thus, the molecules here investigated are potential inhibitors for both the acetylcholinesterase enzymes and juvenile hormone protein–from insect and humans, characterizing them as a potential insecticide against the Aedes aegypti mosquito.

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Section: Resultsmentioning

confidence: 99%

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos

et al. 2019

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“…Video‐tracking techniques, although used in a variety of behavioural studies, have seldom been applied to amphibians and mainly to assess the effects of chemicals on tadpole behaviour (Denoël et al., 2010, 2013; Junges, Maglianese, Lajmanovich, Peltzer, & Attademo, 2017). In our study, ToxTrac allowed to record automatically a plethora of quantitative data for each individual and calculate movement variables with a level of precision that traditional methods cannot allow.…”

Section: Discussionmentioning

confidence: 99%

Strong behavioural defensive responses of endemic Rana latastei tadpoles induced by a native predator's odour

et al. 2020

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Prey species must constantly acquire information on predator identity, abundance and dangerousness from the environment. In aquatic habitats, this information is mainly propagated by water‐borne chemical signals, either predator‐specific odours or prey alarm cues. Anuran larvae innately respond to conspecific alarm cues and are able to associate them to predator cues during their lifetime. In this study, we investigated the anti‐predatory responses of endemic Italian agile frog (Rana latastei) tadpoles exposed to either conspecific or heterospecific alarm cues and a native predator's (Anax imperator larvae) odour. Pre‐and post‐stimulus behaviours of each tadpole were recorded by a digital camera and analysed by a source executable software for image‐based tracking. We found that Italian agile frog tadpoles responded to fasted dragonfly odour by strongly reducing their activity, both in terms of the amount of time they spent active and path length covered in comparison to control groups. Contrary to previous studies, predators' diet had a negligible effect on tadpole response and our experiment did not bring any evidence of the phylogenetic‐relatedness hypothesis. The innate or early‐in‐development recognition of dragonfly larvae is clearly adaptive and may increase tadpole survival with relatively low costs, but, at the same time, may increase the risk of ignoring novel potential threats.

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“…; Junges et al . ). As tsetse flies are found in various habitats, including wetlands, forests, and wooded savannahs, many other insect species are likely to become threatened by large‐scale insecticide treatments.…”

Section: Coextinction Caused By Eradication Programsmentioning

confidence: 97%

“…However, such pyrethroid insecticides are not specific and affect virtually all insect species in treated areas. Even negative effects on vertebrates have been reported (Sayeed et al 2003;Junges et al 2017). As tsetse flies are found in various habitats, including wetlands, forests, and wooded savannahs, many other insect species are likely to become threatened by largescale insecticide treatments.…”

Section: Coextinction Caused By Eradication Programsmentioning

confidence: 99%

License to Kill?—Disease Eradication Programs May Not be in Line with the Convention on Biological Diversity

Hochkirch

Beninde

Fischer

et al. 2017

CONSERVATION LETTERS

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Global human population growth is associated with many problems, such as food and water provision, political conflicts, spread of diseases, and environmental destruction. The mitigation of these problems is mirrored in several global conventions and programs, some of which, however, are conflicting. Here, we discuss the conflicts between biodiversity conservation and disease eradication. Numerous health programs aim at eradicating pathogens, and many focus on the eradication of vectors, such as mosquitos or other parasites. As a case study, we focus on the "Pan African Tsetse and Trypanosomiasis Eradication Campaign," which aims at eradicating a pathogen (Trypanosoma) as well as its vector, the entire group of tsetse flies (Glossinidae). As the distribution of tsetse flies largely overlaps with the African hotspots of freshwater biodiversity, we argue for a strong consideration of environmental issues when applying vector control measures, especially the aerial applications of insecticides. Furthermore, we want to stimulate discussions on the value of species and whether full eradication of a pathogen or vector is justified at all. Finally, we call for a stronger harmonization of international conventions. Proper environmental impact assessments need to be conducted before control or eradication programs are carried out to minimize negative effects on biodiversity.

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Acute Toxicity and Etho-toxicity of Three Insecticides Used for Mosquito Control on Amphibian Tadpoles

Cited by 22 publications

References 41 publications

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos

Strong behavioural defensive responses of endemic Rana latastei tadpoles induced by a native predator's odour

License to Kill?—Disease Eradication Programs May Not be in Line with the Convention on Biological Diversity

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