1978
DOI: 10.1016/0041-008x(78)90027-3
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Acute toxicity and gross behavioral effects of amphetamine, four methoxyamphetamines, and mescaline in rodents, dogs, and monkeys

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Cited by 30 publications
(7 citation statements)
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“…This is in accordance with Hardman et al (1973) who described LD50 in Sprague-Dawley rats to be 132 mg/kg after i.p injection, but in contrast with the findings of Speck (1957) who described in male albino rat the LD50 to be 370 mg/kg after i.p. administration and with Davis et al (1978) who described LD50 in male Sprague-Dawley rats to be 270 mg/kg i.p.. Speck (1957), in his study, described that flexor convulsions and respiratory arrest were the terminal events of animals; Davis et al (1978) described that rats were very inactive, hypoactive, they showed repetitive swimming-like movements, and that they had muscular weakness and ataxia. In our setting, we observed that animals elicited a flat body posture along with hyperlocomotion and almost no rearing.…”
Section: Discussionmentioning
confidence: 97%
“…This is in accordance with Hardman et al (1973) who described LD50 in Sprague-Dawley rats to be 132 mg/kg after i.p injection, but in contrast with the findings of Speck (1957) who described in male albino rat the LD50 to be 370 mg/kg after i.p. administration and with Davis et al (1978) who described LD50 in male Sprague-Dawley rats to be 270 mg/kg i.p.. Speck (1957), in his study, described that flexor convulsions and respiratory arrest were the terminal events of animals; Davis et al (1978) described that rats were very inactive, hypoactive, they showed repetitive swimming-like movements, and that they had muscular weakness and ataxia. In our setting, we observed that animals elicited a flat body posture along with hyperlocomotion and almost no rearing.…”
Section: Discussionmentioning
confidence: 97%
“…As amphetamine and many other hallucinogens provoke abnormal locomotion in laboratory animals it has been suggested that this is a response to hallucination (Davis, Bedford, Buelke, Guinn, Hatoum, Waters, Wilson & Braude, 1978). This raises the possibility that not only catecholamine neurones but also 5-HT neurones are involved in the development of amphetamine psychosis and that backward walking in particular may be worth investigation as a potential animal model for human amphetamine psychosis, and therefore for paranoid schizophrenia which it closely resembles (Snyder, 1973;Woodrow et al, 1978).…”
Section: Discussionmentioning
confidence: 99%
“…Species variations in [DA] o and V max have important consequences for extrapolation of sensitivity to therapeutic, abused, and toxic drugs that require access to the DAT. Higher doses of the psychostimulants cocaine and D-amphetamine/methamphetamine are routinely required in rodents than in primates for experimental and neurotoxic actions (Davis et al, 1978;Melega et al, 1998); although they are caused in part by differing drug metabolism (Melega et al, 1998), dose differences may also result from underlying variation in DAT [or DAT/VMAT (Miller et al, 1999)] activity.…”
Section: Characteristics and Regional Heterogeneity In Single Pulse-ementioning
confidence: 99%