Acute Toxicity and Hepatoprotective Effect of Methanolic Extract of Tephrosia calophylla

Adinarayan, K.; Jayaveera, K. N.; Rao, P. Mallikarjuna; Chetty, C. Madhusudhana; Sandeep, Doppalapudi; Swetha, C.; Saleem, Tayyaba

doi:10.3923/rjmp.2011.266.273

Cited by 11 publications

(2 citation statements)

References 4 publications

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“…These activities were due to the presence of polyphenolic compounds and flavonoids in the extracts of T. purpurea (Shah et al, 2011). The methanolic extract of Tephrosia calophylla also possesses hepatoprotective activity due to the presence of flavonoids (Adinarayana et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and pharmacological aspects of Tephrosia genus: A brief review

2019

J App Pharm Sci

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Tephrosia, the plant genus belongs to the family Fabaceae. It belongs to the major group of angiosperms (flowering plants) that comprises more than 350 species which is widely distributed in the regions of tropical and subtropical countries of the world. Since the herbal medicine is in demand due to its fewer associated side effects, the genus Tephrosia is extensively used for the treatment of large number of diseases in traditional medicines. The main aim of this review is to summarize and document the phytochemical and pharmacological activities performed on Tephrosia genus. To promote the continual use of these plants and in order to plan for the future studies, it becomes important to provide a basis by combining a number of available information into a single data covering the different aspects of the plant.

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Section: Introductionmentioning

confidence: 99%

Phytochemical and pharmacological aspects of Tephrosia genus: A brief review

2019

J App Pharm Sci

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“…The number species of Tephrosia are medicinally proved for their various pharmacological activities [1,2]. As T. calophylla belongs to same genus and also an important in traditional system of medicine like ayurveda and used as antimicrobial [3], heapatoprotective [4], antihyperlipidemic [5], cytotoxic [6], antiprotozoal [7], anticancer and anti -HIV [8], anthelmintic [9] and antiulcer drug [10]. It is also used as alternative cure for diseases of the liver, spleen, heart and blood.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antimicrobial Screening of Leaf and Tuber Extracts of Tephrosia calophylla Bedd

Kavitha

2021

JPRI

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Tephrosia calophylla, (Fabaceae) a perennial woody under shrub endemic to south India. It is one of 13 rare or threatened Tephrosia species. Commonly it is known as Adavivempali. The various species of Tephrosia is ascribed to have many medicinal and therapeutic uses. The importance of this study was to preliminary screening of different phytochemical constituents for the detection of various secondary metabolites and evaluation of antibacterial, antifungal activity and Minimum Inhibitory Concentration of the different crude extracts of tuber and leaf. Tuber and leaf both yielded more number of secondary metabolites like alkaloids, phenols, flavonoids tannins, saponins and glycosides with high quantity when compared with the leaf, consisting low quantities of phyto-constituents as steroids and in tuber consisting only tannins. Antibacterial activity of T. calophylla tuber and leaf aqueous and alcohol extracts at 10 mg/well are showing more effective activity on Bacillus subtilis (MTCC-441), Escherichia coli (MTCC-443), Pseudomonas aeruginosa (MTCC-741), Klebsealla neumoniae, Proteus vulgaris strains than the control drug Ampicillin 10 mg/well with 30.25-15.00 mm zone of inhibition. The minimum inhibitory concentration (MIC) with leaf and tuber extracts was 0.312 to 2.50 mg/ml compared to that of the 10 mg of Ampicillin. Antifungal screening of aqueous leaf extract was more effective on Candida albicans with 19.25 mm inhibition zone than Aspergillus niger at 10 mg/well compared to Nystatin the control drug at 10 mg/well with 10.2 to 12.1 mm of zone of inhibition. Fungal MIC on both organisms with leaf and tuber extracts ranges from 0.612 mg to 3 mg compared to 10 mg of Nystatin.

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Hepatoprotective Effect of Ethanolic Extract of Whole Plant of <i>Tephrosia barberi</i> J. R. Drumm. in Paracetamol Induced Hepatotoxicity in Rats

Sameemabegum,

Thilagavathi,

Kumarnallasivan

et al. 2024

JNR

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Background: Tephrosia barberi J. R. Drumm is a novel endemic perennial herb belonging to the Fabaceae family. Aim: To investigate the hepatoprotective activity of the whole plant of T. barberi. Methods: Preliminary phytochemical testing and GCMS analysis were done for the ethanolic extract of T. barberi. Initially, acute toxicity experiments were carried out in which five groups of rats (n=3) were administered with 0.5% carboxymethyl cellulose (normal control), ethanolic extract of T. barberi orally (5, 50, 300 and 2000 mg/kg b.w.) for 14 days daily, there was no mortality observed for 24 hr. For the assessment of the hepatoprotective potential, ethanolic extracts of T. barberi (200mg/kg low dose and 400mg/kg high dose) and silymarin (100mg/kg, employed as the reference standard), distilled water (normal control, paracetamol control) was given orally to five groups of rats (n=6) over seven days. All animals were given paracetamol on the fifth day, following the administration of standard and extracts, except for those in normal control. To assess the levels of serum enzymes, proteins, antioxidant indicators, and histopathological analyses, the rats were sacrificed and blood samples, liver homogenate, and liver sections were taken. Results: Rats fed with T. barberi ethanol extract (400mg/kg/day) and silymarin, a standard drug (100mg/kg/day) treated groups had significantly elevated liver serum enzymes such as alanine phosphatase, aspartate aminotransferase, alanine transaminase, total protein and total bilirubin than the intoxicated rats (p<0.01to p<0.001). Furthermore, the effect of antioxidant parameters (GSH, CAT, and SOD) on hepatic tissue showed that ethanol extract of T. barberi (high dose, 400mg/kg) produced improved hepatic function than toxic control rat and exhibited significant action compared to standard drug. Conclusion: The current research findings strongly indicate that T. barberi has promising hepatoprotective potential due to the presence of flavonoids and phenolic compounds.

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Acute Toxicity and Hepatoprotective Effect of Methanolic Extract of Tephrosia calophylla

Cited by 11 publications

References 4 publications

Phytochemical and pharmacological aspects of Tephrosia genus: A brief review

Phytochemical and pharmacological aspects of Tephrosia genus: A brief review

Phytochemical and Antimicrobial Screening of Leaf and Tuber Extracts of Tephrosia calophylla Bedd

Hepatoprotective Effect of Ethanolic Extract of Whole Plant of <i>Tephrosia barberi</i> J. R. Drumm. in Paracetamol Induced Hepatotoxicity in Rats

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